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Identifying baseline pain indicators for phantom limb pain in amputee patients
Full text linkThis quality improvement project identified significant gaps in the documentation of phantom limb pain (PLP) among amputee patients, revealing that PLP was often absent from formal diagnosis lists and that pain assessments were frequently incomplete. By retrospectively reviewing 32 inpatient charts, the project highlighted the need for standardized, multidimensional pain assessment tools and improved electronic health record practices to support accurate evaluation and future implementation of virtual reality (VR) therapies for PL
Evaluating deformable image registration for cumulative dose estimation in gynecologic brachytherapy
Full text linkThis thesis evaluates the use of deformable image registration (DIR) for dose accumulation in gynecological HDR brachytherapy. By comparing DIR-based and conservative methods, it assesses the impact of anatomical motion and registration accuracy on cumulative dose estimates to organs at risk and target volumes. The study highlights the clinical relevance of DIR, particularly for mobile organs like the small bowel and rectum, and supports the use of hybrid-based DIR for for improved accuracy
Assessing HPV vaccine uptake and access barriers among young adults enrolled in post-secondary education in Oregon: recommendations for targeted outreach
Full text linkHPV remains a major cause of cancer in the U.S., yet young adults—especially college students—often face limited vaccine access. The Knight Cancer Institute’s Mobile Outreach program addressed this gap by bringing vaccines to underserved campuses in Oregon. Interviews and surveys revealed key barriers like cost, lack of on-site availability, and billing limitations, particularly at smaller and rural schools. Expanding OHP enrollment, improving outreach logistics, and using peer-led education were recommended to boost vaccine uptake and reduce disparities
The effects of registered dietitian order writing and timeliness of NICU supplement orders
No full textThe Neonatal Intensive Care Unit (NICU) provides essential care for preterm infants, the smallest and most nutritionally vulnerable patient population. It is crucial for these infants to receive the appropriate dosage of supplements that is tailored to their growth, weight, and age, and that is administered in a timely manner. This capstone project with accompanying quality improvement report examines the accuracy and timeliness of supplement orders before and after registered dietitians were granted ordering privileges. The project compares orders from 2019 (before dietitians had order-writing privileges) to those from 2021 (after dietitians received these privileges) at Providence St. Vincent Medical Center
Oral health for all: addressing dental disparities in the Columbia Gorge
Full text linkPartnering with the Columbia Gorge Health Council, our team conducted stakeholder interviews and a literature review to assess oral health disparities in the Columbia Gorge, with a focus on OHP members. We identified key barriers, including workforce shortages, low Medicaid reimbursement, and logistical access issues, as well as existing facilitators like school-based care, integrated models, and patient navigation. Our recommendations span four focus areas: workforce development, strategic partnerships, integrated care, and systemic reform. Together, these strategies aim to expand sustainable, high-quality oral health access for underserved communities in the region
Cognitive signaling in cerebellar Purkinje cells during decision-making
No full textThe cerebellum has traditionally been associated with motor control. However, increasing evidence suggests that it also plays a critical role in cognitive processing. Despite this shift in perspective, the precise nature of the cognitive signals conveyed to the cerebellum remains poorly understood. This dissertation aims to address this gap by investigating the activity of cerebellar Purkinje cells during perceptual decision-making through a combination of approaches, including animal behavior, two-photon calcium imaging, and optogenetics. Specifically, it examines the types of information transmitted via climbing fiber inputs to Purkinje cell dendrites during an auditory cognitive task and assesses whether Purkinje cell firing itself is sufficient to drive perceptual behavior
The role of FBXW7 in CNS myelination
Full text linkMyelination in the CNS is essential for neuronal function, and oligodendrocytes achieve this by wrapping axons with multilayered myelin sheaths. We identify FBXW7 as a key regulator of this process, acting through stage-specific control of oligodendrocyte development and by limiting MYRF activity to prevent pathological myelin overgrowth. These findings position FBXW7 as a critical integrator of transcriptional and proteostatic mechanisms that safeguard myelin structure and neural circuit integrity
Wearable-derived autonomic metrics for predicting metabolic and hepatic risk: insights from AI-READI
Full text linkThis study examined whether wearable-derived autonomic function metrics (WOMAFs) could help predict risk for Type 2 Diabetes and liver fibrosis due to MASLD. While WOMAFs alone had limited predictive value, combining them with clinical measures modestly improved risk stratification using data from the AI-READI dataset