OHSU Digital Collections (Oregon Health and Science University)
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38149 research outputs found
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Preventing burnout in future educators
No full textBurnout is a critical issue in educators influenced by numerous modifiable stressors that has worsened as a result of the COVID-19 pandemic. The goal of this capstone project is to to empower future educators with the proper knowledge and tools to combat burnout before they enter the workforce
Investigating the function of PARP7 in type 1 interferon transcriptional regulation
No full textThis dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It identifies the transcriptional coactivators p300 and CBP, as well as IRF3, as key PARP7 substrates, showing that their MARylation drives their degradation or nuclear clearance to repress IFN-I transcription. Additionally, it reveals that PARP7’s own auto-MARylation controls its stability and activity, offering new mechanistic insights and potential therapeutic strategies for enhancing antitumor immunity by targeting PARP7 or its interactions with p300, CBP, and IRF3
Improving inference from EHR data: application of causal inference to pancreatic ductal adenocarcinoma
No full textElectronic health records (EHRs) provide a voluminous amount of data for research. However, potential biases threaten the internal and external validity of observational studies re-using EHR data for research. We visualized potential biases introduced into the EHR during its data generation process and employed directed acyclic graph (DAG), a causal inference tool, to minimize potential confounding and selection biases. We developed a framework to generate causal DAG and applied it to analyze pancreatic ductal adenocarcinoma
Characterization of the gene transcriptional response in mouse mesocorticolimbic circuitry following adolescent social isolation
No full textAdolescent social isolation is a developmental stressor that increases vulnerability to neuropsychiatric disorders including substance use disorder and eating disorders. This dissertation characterizes murine brain changes associated with adolescent social isolation
