AXSIS (Yeditepe Üniversitesi)
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Physician and Patient Preferences for Oral Anticoagulation Therapy Decision Making in Atrial Fibrillation: Results From a National Best–Worst Scaling Survey in Türkiye
No full textAtrial fibrillation (AF) is the most common cardiac dysrhythmia and a common cause of ischemic stroke. Stroke prevention with oral anticoagulation (OAC) is the cornerstone of AF management. Patients and their treating physicians may have different views on different attributes of OACs. The objective of this study was to quantify the relative importance that patients and physicians in Turkey place on different OAC attributes when making treatment decisions in AF. A cross-sectional survey was administered to AF patients (≥ 50 years) receiving OAC and practising cardiologists, including residents with ≥ 2 years of experience in Turkey. For both patients (N 230; 50 male) and physicians (N 194; 74 male), the most important attributes for OAC treatment decision making in AF were “success in preventing stroke” (57 and 73.9 or overall importance, respectively) and “risk of major bleeding” (20 and 23.4, respectively). For patients, other attributes were much less important, but not altogether unimportant: reversal agent availability (7), monitoring (5), food or drug interactions (3), minor bleeding (3), and ease of swallowing (2). For physicians, among the other attributes, only the need for monitoring (1.3) had a relative importance of > 1. For all Turkish participants, efficacy and safety were found to be the most important attributes influencing OAC choice in AF with these two attributes accounting for 77 and 97.3 of overall importance for patients and physicians, respectively. Certain considerations, especially reversal agent availability and monitoring appear to be more important to patients than to physicians This is the first study to use BWS to quantify patient and physician preferences for OAC treatments in AF in Turkey. © 2024 The Author(s). Clinical Cardiology published by Wiley Periodicals, LLC.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Analyzing point defect polarization in tungsten and tungsten carbide under high gamma irradiation for radiation shielding applications
No full textThe Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Hypoprolactinemia. Does it matter? Redefining the hypopituitarism and return from a mumpsimus: “Absence of proof is not the proof of absence”
No full textProlactin (PRL) is secreted by the lactotroph cells in the anterior pituitary gland which is under inhibitory control of dopamine. The mature human PRL has more than 300 physiological actions including lactation, reproduction, homeostasis, neuroprotection, behavior, water and electrolyte balance, immunoregulation and embryonic and fetal development. PRL is involved in the growth and development of mammary gland, preparation of the breast for lactation in the postpartum period, synthesis of milk, and maintenance of milk secretion. Abnormalities in the synthesis and secretion of PRL may result in hyperprolactinemia or hypoprolactinemia. Although hyperprolactinemia has been extensively investigated in the literature, because of the subtle or unclearly defined symptoms, hypoprolactinemia is a less-known and neglected disorder. Failure of lactation is a well-known clinical manifestation of hypoprolactinemia. Recent studies reveal that hypoprolactinemia may have some effects beyond lactation such as increased risk for metabolic abnormalities including insulin resistance, abnormal lipid profile, obesity and sexual dysfunction. Very low level of PRL is suggested to be avoided in patients receiving dopamin agonist treatment to prevent unwanted effects of hypoprolactinemia. Another important point is that hypoprolactinemia is not included in the classification of hypopituitarism. Anterior pituitary failure is traditionally classified as isolated, partial and complete (panhypopituitarism) hypopituitarism regardless of prolactin level. Therefore, there are two kinds of panhypopituitarism: panhypopituitarism with normal or high PRL level and panhypopituitarism with low PRL level. In this review, we present two personal cases, discuss the diagnosis of hypoprolactinemia, hypoprolactinemia associated clinical picture and suggest to redefine the classification of hypopituitarism. © The Author(s), under exclusive licence to Springer ScienceBusiness Media, LLC, part of Springer Nature 2023.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Chrysin alleviates salt stress in tomato by physiological, biochemical, and genetic mechanisms
No full textSoil salinity greatly reduces agricultural productivity, especially in dry and semi-arid regions, by interfering with physiological and biochemical processes. This research aimed to determine whether Chrysin (Chr) can mitigate the negative effects of salinity on growth parameters, antioxidant enzyme activity, and gene expression in tomato (Solanum lycopersicum L.) plants. Experiments were conducted in a semi-controlled greenhouse, with plants subjected to varying concentrations of sodium chloride (NaCl) (0 and 100 mM) and Chr (0, 0.1, 0.5, and 1.0 mM). Results revealed that salinity stress significantly reduced plant height, leaf area, and chlorophyll content while increasing hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline levels, indicating oxidative stress. Chr application alleviated these detrimental effects by enhancing the activity of antioxidant enzymes such as catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD), thereby reducing reactive oxygen species (ROS) accumulation. Additionally, Chr treatments improved plant water status and mineral content under salt stress. Gene expression analysis showed that Chr positively regulated the transcription of salt tolerance-related genes, including HKT1-1, HKT1-2, and PIP1-2, which are associated with sodium ion transport and water balance. These findings suggest that Chr can be an effective biostimulant for enhancing salt tolerance in tomato plants by modulating physiological, biochemical, and genetic mechanisms. This study provides insights into Chr's potential as a sustainable solution for improving crop resilience to salinity in agricultural practices. Further research is recommended to optimize Chr concentrations for maximum efficacy. © 2024The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1
No full textBackground: T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid leukemia (AML) cells and it is related to AML progression. As, Glutamine appears to play a prominent role in malignant tumor progression, especially in their myeloid group, therefore, in this study we aimed to evaluate the relation between TIM-3/Galectin-9 axis and glutamine metabolism in two types of AML cell lines, HL-60 and THP-1. Methods: Cell lines were cultured in RPMI 1640 which supplemented with 10 FBS and 1 antibiotics. 24, 48, and 72h after addition of recombinant Galectin-9 (Gal-9), RT-qPCR analysis, RP-HPLC and gas chromatography techniques were performed to evaluate the expression of glutaminase (GLS), glutamate dehydrogenase (GDH) enzymes, concentration of metabolites; Glutamate (Glu) and alpha-ketoglutarate (α-KG) in glutaminolysis pathway, respectively. Western blotting and MTT assay were used to detect expression of mammalian target of rapamycin complex (mTORC) as signaling factor, GLS protein and cell proliferation rate, respectively. Results: The most mRNA expression of GLS and GDH in HL-60 cells was seen at 72h after Gal-9 treatment (p 0.001, p 0.0001) and in THP-1 cell line was observed at 24h after Gal-9 addition (p 0.001, p 0.0001). The most mTORC and GLS protein expression in HL-60 and THP-1 cells was observed at 72 and 24h after Gal-9 treatment (p 0.0001), respectively. MTT assay revealed that Gal-9 could promote cell proliferation rate in both cell lines (p 0.001). Glu concentration in HL-60 and α-KG concentration in both HL-60 (p 0.03) and THP-1 (p 0.0001) cell lines had a decreasing trend. But, Glu concentration had an increasing trend in THP-1 cell line (p 0.0001). Conclusion: Taken together, this study suggests TIM-3/Gal-9 interaction could promote glutamine metabolism in HL-60 and THP-1 cells and resulting in AML development. © 2024, The Author(s).The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive.Cell lines were cultured in RPMI 1640 which supplemented with 10% FBS and 1% antibiotics. 24, 48, and 72 h after addition of recombinant Galectin-9 (Gal-9), RT-qPCR analysis, RP-HPLC and gas chromatography techniques were performed to evaluate the expression of glutaminase (GLS), glutamate dehydrogenase (GDH) enzymes, concentration of metabolites; Glutamate (Glu) and alpha-ketoglutarate (α-KG) in glutaminolysis pathway, respectively. Western blotting and MTT assay were used to detect expression of mammalian target of rapamycin complex (mTORC) as signaling factor, GLS protein and cell proliferation rate, respectively
Does paternal acception also matter? The mediating role of self-compassion in the relationship between parental acceptance and eating attitude
No full textParental factors have received significant attention, even though eating disorders—which have been more prevalent recently—are known to involve numerous psychological components. Notably, maternal behavior and gender have been significant in studies of disordered eating and eating disorders. However, studies of paternal behavior are limited, and these studies are predominantly related to gender. Although various negative parenting behavior is associated with eating disorders and disordered eating behaviors, it is evident that addressing these behaviors would be more efficacious in treating unhealthy eating attitudes than working with the parents of these individuals. In this study, self-compassion was considered a formable trait and a mediating variable in the relationship between parental rejection and disordered eating behaviors. Two separate models were tested for maternal and paternal rejection, with gender as a control variable. A descriptive survey method was employed. The sample group of 456 consisted of adults who agreed to participate in the study through the consent form and filled in the self-report scales through Google Forms. The results of the study indicated that self-compassion fully mediated the relationship between maternal rejection and disordered eating behaviors, and partially mediated the relationship between paternal rejection and disordered eating behaviors. This finding indicates that self-compassion is a feature worthy of study in the treatment process of individuals with disordered eating, as well as the need for more scientific studies on paternal behaviors in disordered eating. © The Author(s), under exclusive licence to Springer ScienceBusiness Media, LLC, part of Springer Nature 2024.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Measurements of Lund subjet multiplicities in 13 TeV proton-proton collisions with the ATLAS detector
No full textThis Letter presents a differential cross-section measurement of Lund subjet multiplicities, suitable for testing current and future parton shower Monte Carlo algorithms. This measurement is made in dijet events in 140 fb−1 of s13 TeV proton–proton collision data collected with the ATLAS detector at CERN's Large Hadron Collider. The data are unfolded to account for acceptance and detector-related effects, and are then compared with several Monte Carlo models and to recent resummed analytical calculations. The experimental precision achieved in the measurement allows tests of higher-order effects in QCD predictions. Most predictions fail to accurately describe the measured data, particularly at large values of jet transverse momentum accessible at the Large Hadron Collider, indicating the measurement's utility as an input to future parton shower developments and other studies probing fundamental properties of QCD and the production of hadronic final states up to the TeV-scale. © 2024 CERN for the benefit of the ATLAS CollaborationThe Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Validity and reliability of the Turkish version of the Maternal Health Literacy Inventory in Pregnancy scale: a methodological study
No full textPurpose: This study aimed to translate the Maternal Health Literacy Inventory in Pregnancy (MHELIP) scale into Turkish and evaluate its validity and reliability for use in the Turkish population. Methods: The participants in this methodological study included 250 pregnant women who presented to the antenatal clinic of the Florence Nightingale Hospital in Istanbul, Turkiye. Content validity was assessed using expert approval. Confirmatory factor analysis, exploratory factor analysis, and structural equation modeling were used to assess the validity. Criterion validity was evaluated using the short-form health literacy survey tool, the Short-Form Health Literacy Questionnaire (HLS-SF12). To assess reliability, Cronbach’s alpha, item analysis, and the test-retest method were used. Results: The mean age of the participants was 32.02±4.15 years. The content validity index of the scale was .99. The scale had a four-factor structure that fit well with 48 items. “Maternal health knowledge,” “maternal health information search,” “maternal health information assessment,” and “maternal health decision making and behavior” subscales had Cronbach’s alpha values of .91, .76, .85, and .90, respectively. The MHELIP and HLS-SF12 scores were significantly correlated (r.422, p<.001). Conclusion: The MHELIP was found to be a valid and reliable measurement tool in pregnant Turkish women. © 2024 Korean Society of Women Health Nursing.The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Public health challenges after the February 6 earthquakes: A comprehensive review of immediate and long-term impacts in Türkiye
No full textEarthquakes are one of the most destructive natural hazards that cause loss of life, loss of property and destruction of infrastructure when they interact with vulnerabilities in human systems. The health impacts of these events are not only limited to immediate trauma and injuries, but also affect both physical and mental health in the short and long term. In this context, understanding the short- and long-term public health impacts of earthquakes and developing effective solutions is a priority both nationally and internationally. This review comprehensively examines the health challenges posed by earthquakes, focusing on the earthquakes that occurred in Türkiye on February 6, 2023. It addresses acute responses such as post-earthquake trauma management, emergency health services, potential earthquake-related risks and search and rescue activities, as well as chronic challenges such as sustained physical rehabilitation and psychosocial support in the long term. By analyzing current strategies and outcomes, this study aims to provide important insights into effective health management practices following earthquakes. © 2024 Elsevier LtdThe Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
One-step synthesis of a piezoelectric hybrid BNNT/BaTiO3 composite and its application in bone tissue engineering
No full textNanomaterials with piezoelectric properties can significantly improve the applicability of polymers used in tissue engineering applications. In this study, we report the one-step synthesis of a novel hybrid piezoelectric composite comprising barium titanates and boron nitride nanotubes. This composite is distinguished by its unique microstructures, including nanoflakes, triangular boron nitride structures, and fiber-like boron nitride nanotube configurations, which contribute to its enhanced piezoelectric properties. The composite was incorporated into a chitosan-based tissue scaffold and evaluated in vitro. Electric-responsive Human Osteoblast cells cultured on the scaffolds are exposed to low-frequency ultrasound stimulation during cell growth. The biocompatibility, cell adhesion, alkaline phosphatase activities, and mineralization of osteoblast cells on the piezo-composite scaffolds were evaluated. The results show that the hybrid piezoelectric composite significantly enhances the properties of chitosan-based scaffold. © 2024The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive