Medico Research Chronicles
Not a member yet
767 research outputs found
Sort by
TELBIVUDINE IN THE TREATMENT OF HEPATITIS B VIRUS REACTIVATION IN CANCER PATIENTS RECEIVING CHEMOTHERAPY
Get PDFBackground & Aims: Hepatitis B virus Reactivation (HBVR) in cancer patients receiving chemotherapy is potentially fatal condition and needs prompt diagnosis and treatment. Treatment of such patients has been attempted with lamivudine, entecavir, and tenofovir with variable success rates. Although a rapidly acting highly potent antiviral, telbivudine has not been studied in HBVR and our aim was to study the efficacy of telbivudine in such patients.
Methods: This prospective study of four patients with HBVR who were suffering from different malignancies was conducted in a tertiary care center. These patients were referred with transaminitis and on investigating proved to be having HBVR. After starting them on Telbivudine 600mg OD, these patients were followed very closely on OPD basis.
Results: 3 out of 4 patients developed HBsAg seroconversion and the drug could be stopped within 1 year of treatment in all three of them. In one patient, HBe seroconversion was achieved.
Conclusions: Telbivudine is an effective alternative to entecavir and tenofovir in cancer patients with HBVR
METFORMIN INDUCED LACTIC ACIDOSIS AND ACUTE RENAL FAILURE
Get PDFMetformin is a biguanide agent and oral antihyperglycemic agent used in the treatment of type 2 diabetes mellitus. Metformin-associated lactic acidosis and acute renal failure is a very rare but life-threatening side effect of metformin. We present the case of a nondiabetic 41 years old woman, who attempted to commit suicide by ingesting more than 20 grams of metformin. She presented with lactic acidosis and acute renal failure to the emergency department. She was successfully treated by hemodialysis. The main treatment method is hemodialysis who presents with lactic acidosis and acute renal failure in metformin intoxication
PSYCHO NEUROBICS ON SMOOTH HARMONAL CHANGES IN WOMEN
Get PDFHormones assume an indispensable job in the health of human females and hormonal lopsidedness can cause a few obsessive conditions. Ill-advised eating regimen, unpleasant or discouraged ways of life and utilization of medications can cause hormonal unevenness. This investigation intended to discover the reasons for hormonal irregularity in females matured between 15-40 years. A cross-sectional and irregular inspecting strategy was utilized to gather data from youthful females of this age amass in Karachi, Pakistan. An extraordinarily planned survey was utilized for data accumulation and a sum of 127 females took part in the investigation. 55% of the females had unpredictable periods, 39% had intemperate hair development on the face or body, and 6% had the two conditions. 11% of the female took shoddy nourishments, 6.2% were vegetarians, 14.96% took zesty sustenance, and 60.62 % took all the three kinds of nourishment. 36% took both vegetable and shoddy nourishments, and 4.72% took both garbage and fiery sustenances. Likewise, 59% of the females took no treatment, 26% took anti-toxins, 10.25% were on hormone substitution treatment (HRT), and 4.75% took the two anti-infection agents and HRT. 21.26% had wretchedness, 24.41% had remaining burden, 1.6% had both misery and outstanding task at hand while 52.73% had no explicit reason for their hormonal unevenness
AN INCIDENTIAL FINDING OF HYPERCALCEMIA IN A PATIENT WITH ACUTE MYLOID LEUKAEMIA
Get PDFHypercalcemia complicating leukemia is a rare, but well-recognized finding. Few case reports have been documented in various journals. The etiology in most cases is not fully understood; however, there is an established fact that there is a link with cytokine release. We report a case of a 65year-old man who presented with hypercalcemia, during the course of his illness. Possible causes of hypercalcemia such as hyperparathyroidism, vitamin D intoxication, solid tumors, and ectopic parathyroid hormone production were excluded. From the case report, it is concluded that leukemia may be complicated by hypercalcemia and physicians should bear this in mind as they manage patients with leukemia
CARCINOMA OF UTERINE CERVIX WITH MULTIPLE SKULL METASTASES AS THE FIRST PRESENTATION OF RECURRENCE: A CASE REPORT
Get PDFCarcinoma of cervix recurring as multiple skull metastasis is a very rare presentation. A 49-yearold woman, a diagnosed case of carcinoma cervix [International Federation of Gynecology and Obstetrics (FIGO) stage IB1] treated with radical hysterectomy presented with generalized seizures to us after 40 months of initial diagnosis. Contrast-enhanced computed tomography showed metastasis to left temporoparietal bone and left frontal bone. Biopsy from the left temporal lesion showed non-keratinizing squamous cell carcinoma. She was thus diagnosed as recurrent carcinoma cervix with multiple calvarial metastases with the controlled primary site. She received palliative radiotherapy to the entire skull. She further received 4 cycles of palliative chemotherapy with paclitaxel and carboplatin repeated every 3 weeks. However, she could not tolerate chemotherapy after 4 cycles owing to significant deterioration of performance status and expired after 12 months of diagnosis of metastasis
DENTURE LABELING: A BOON OR BANE
Get PDFIdentification of a person through forensic science is an art of giving the corpse a name. Denture markers play an important role in forensic odontology and also in identifying a deceased person. A number of methods are used. Out of the differently available denture markers, the barcoding system is a way of collecting data from the mobile. It can be easily incorporated during the fabrication process of the denture and thus could be helpful in identification. This article reviews the importance of bar-coding and how easily it can be used in the routine procedure
THE DETERMINANTS AND CONSEQUENCES OF INTIMATE PARTNER VIOLENCE AMONG PREGNANT WOMEN IN TERTIARY HEALTH INSTITUTIONS IN ABIA STATE, NIGERIA
Get PDFBackground: It has been documented that pregnant women who are exposed to intimate partner violence (IPV) are prone to the risk of complications both for the mother and the baby. There is a need to identify the reasons for this abuse.
Objectives: To identify the prevalence, determinants, and consequences of Intimate Partner Violence (IPV) among pregnant women in Tertiary Health Institutions in Abia State.
Materials and Method: This was a cross-sectional Study of 214 pregnant women attending the antenatal clinic in the two Tertiary Health Institutions in Abia State using pretested questionnaires administered to attendees who consented to participate. Analysis of data was done using SPSS Version 16.
Results: The mean age of the 214 participants was 30.15 ± 5.88 years. The Prevalence of intimate partner violence among pregnant women in our study was 32.7 %( 70/214). We did not establish any statistical association between age of women or that of her partner, duration of the marriage, her religion, parity or educational status of the partner and IPV (p>0.05). We established a statistically significant association between social habits of the partner and IPV (p< 0.05). About 31 %( 22) of the IPV victims had sustained an emotional/ physical injury while 20 % (14) had been hospitalized. Social habits of the spouse (13%) were the highest trigger for the abuse followed by financial problems (10%). Majority of victims 68.6 %( 48) did not feel the abuse should be reported.
Conclusion: This study demonstrates a high prevalence of IPV among pregnant women
NUTRITION FOR PANCREATIC SURGERY
Get PDFThe American novelist Leo Rosten (1908-1997) once said: “Some things are so unexpected that no one is prepared for themâ€. This statement probably epitomizes what pancreatic cancer is. This highly aggressive malignancy is characterized by early malnutrition, cachexia, and early metastasis. With no reliable method for early detection when carcinoma pancreas is usually diagnosed, it has already advanced and less than 20 % of patients are candidates for surgery. Patients affected with pancreatic cancer have a dismal survival (1- and 5-year relative survival rates are 29% and 7%, respectively)
IMPACT OF YOGA AND MEDITATION ON CELLULAR AGING
Get PDFThis examination was intended to investigate the effect of Yoga and Meditation based way of life mediation (YMLI) on cell maturing in obviously healthy people. Amid this 12-week imminent, open-name, single arm exploratory examination, 96 obviously healthy people were enlisted to get YMLI. The essential endpoints were evaluation of the adjustment in dimensions of cardinal biomarkers of cell maturing in blood from gauge to week 12, which included DNA harm marker 8-hydroxy-2-deoxyguanosine (8OH2dG), oxidative pressure markers responsive oxygen species (ROS), and aggregate cancer prevention agent limit (TAC), and telomere steady loss markers telomere length and telomerase activity. The optional endpoints were an appraisal of metabotropic blood biomarkers related to cell maturing, which included cortisol, -endorphin, IL-6, BDNF, and sirtuin-1. Following 12 weeks of YMLI, there were noteworthy upgrades in both the cardinal biomarkers of cell maturing and the metabotrophic biomarkers impacting cell maturing contrasted with gauge esteems. In this paper, we discuss about the impact of yoga and meditation on cellular aging
INSTANT REDUCTION IN BLOOD SUGAR LEVEL BY PRACTICING ONE HOUR 30 MINUTES OF PSYCHONEUROBICS
Get PDFModern day society knows about the benefits of psychoneurobics. Psychoneurobics straightforwardly impacts every one of the frameworks and organs of the body. This study inspecting social ways to deal with lighten the force and anticipate advancement of diabetes mellitus. What\u27s more, to improve diabetes self-administration by rehearsing psychoneurobics. There were 22 male and 8 female members with diabetes .Intervention program was for 3 months. Before the intercession program began, second and third months blood investigate fasting and after nourishment were gathered. Correlation of pre-post blood test have been finished. There was a huge contrast seen at 1% level. No huge contrast found in connection with sexual orientation and also with age length of the members. The portion of the prescription routine continued as before under the convention. An adjustment in the way of life received by the member was that the act of psychoneurobics for 60 minutes. Alongside a dietary change, ideally veggie lover nourishment were prescribe