Van Yüzüncü Yıl University Research Information System
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Kültürel kimliğin mimari cephelerdeki yansıması: Ankara’daki Geleneksel Türk ve Yahudi evleri (İstiklal Mahallesi) üzerine sayısal bir karşılaştırma
No full textBu çalışma, aynı coğrafi bağlam içinde yer alan ancak farklı kültürel ve dini geçmişe sahip iki topluluğun—Türk ve Yahudi cemaatlerinin—geleneksel konut cepheleri üzerindeki morfolojik farklarını nicel yöntemlerle incelemeyi amaçlamaktadır. Araştırma, mimari cephelerin yalnızca fiziksel yüzeyler değil, aynı zamanda sosyal kimliklerin, kültürel değerlerin ve yaşam biçimlerinin somut birer yansıması olduğu varsayımına dayanmaktadır. Çalışmada fraktal boyut, solid/void oranı, açıklık oranı ve simetri düzeyi olmak üzere dört temel parametrik ölçüt kullanılmıştır. Örneklem, Ankara'nın tarihi Yahudi ve Türk mahallelerinden seçilen, özgünlüğünü koruyan toplam 20 geleneksel konuttan oluşmaktadır. Görsel veriler ImageJ yazılımında işlenmiş; fraktal analiz için FracLac eklentisi, simetri ve boşluk oranı analizleri için ise görsel eşikleme ve hesaplama araçları kullanılmıştır. Elde edilen veriler SPSS ortamında istatistiksel olarak değerlendirilmiştir. Bulgular, Yahudi evlerinin daha yüksek fraktal değerler ve açıklık oranlarına sahip olduğunu, Türk evlerinin ise daha simetrik ve mahremiyet odaklı bir cephe düzeni sergilediğini göstermektedir. Bu farkların, kültürel normlar ve yaşam biçimlerine dayalı biçimsel tercihlerle doğrudan ilişkili olduğu sonucuna ulaşılmıştır. Sonuç olarak, bu çalışma fraktal analiz ve parametrik yöntemlerin, kültürel mimari farklılıkların nicel olarak saptanmasında etkili araçlar olduğunu göstermekte; koruma ve yeniden yapılandırma süreçlerine bilimsel bir temel sunmaktadır.</p
Review: recent developments in 2D MXene-filled bioinspired composites for biomedical applications
No full textTwo-dimensional carbide- and nitride-based MXene materials have become some of the most studied materials in interdisciplinary fields due to their superior properties. This review comprehensively discusses recent advances in MXene materials such as bioinspired coating films, scaffolds, and electrochemical activities for use in biomedical fields. MXene consists of multilayer 2D nitride, carbide, or carbonitride flakes with excellent electrical conductivity, large surface area, and good mechanical properties. Bibliometric studies have revealed a sharp increase in the number of publications and citations, having reached 15,831 records as of February 2025. Notably, the number of citations surged from under 20 in 2012 to over 222,000 in 2024. Due to being two-dimensional materials with superior physicochemical and biological properties, MXenes are also being increasingly used in biomedical and engineering applications. They have been reported to be ideal for such biomedical applications as corrosion-resistant biofilms, biocompatibility, low toxicity, drug delivery, and tissue engineering. In addition, MXene-based scaffolds have emerged as a promising material for bone tissue engineering due to their extraordinary mechanical durability, biocompatibility, and adjustable surface properties. By aiding tissue regeneration and preventing infections, MXene scaffolds have also been found to exhibit enhanced drug delivery and antibacterial properties. Recent advances in materials science have focused on creating bioinspired structures with multifunctionality. Taking into account MXenes’ multilayered structures and functional surfaces, unique physicochemical properties have been designed by learning from nature to produce bioinspired materials. This article comprehensively reviews biomedical applications of such 2D MXene materials as bioinspired coating films, scaffolds as biosensors, drug delivery, cancer treatments, and tissue regeneration.</p
Determination of Fruit Quality Characteristics of Pear Genotypes Growing Naturally in Van Province
No full textGebelik ve Doğum Süreçlerinde Çeşitlilik: Adölesan, Normal ve Riskli Gebeliklerin Analizi ve Doğum Korkusu
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Characterization of Outer Membrane Vesicles (OMVs)from Helicobacter pylori Strains Isolated from Turkish Patients
No full textAhşap Esaslı Kompozit Levha Malzemeleri Yüzey Renk Özellikleri Üzerine Sıcak Su Buharının Etkileri
No full textNovel quinoline derivative and Artemisia spicigera alleviates against propanil-induced toxicity: the in vitro and in vivo biological evaluation
No full textPropanil is the most widely used herbicide in the world, which posing a great threat to environmental health. A novel heterocycle featuring quinoline and anthracene linked by a triazole bridge within a single scaffold has been developed using a molecular hybridization strategy. The present study was conducted to evaluate the potential nephroprotective and hepatoprotective properties of a newly synthesized 1,2,3-triazol-quinoline derivative (TQD) and Artemisia spicigera K.Koch. in relation to SOD, CAT, GSH-Px, MDA, GSH, PCO, Co, Cu, Zn levels in the kidney and liver tissues, TSA, α-tocopherol, cholecalciferol, retinol, and phylloquinone in the serum samples and histopathological alterations and caspase-3 expression immunohistochemically in the female rats exposed to propanil (PRP)-mediated oxidative stress. In the study, a total of fifty-six Wistar albino female rats were assigned into seven groups; control, olive oil, PRP (200 mg/kg), TQD (0.4 mg/kg), Artemisia spicigera (300 mg/kg), PRP (200 mg/kg) + A. spicigera (300 mg/kg), and PRP (200 mg/kg) + TQD (0.4 mg/kg/). According to analysis results, significantly decreased liver and kidney tissue GSH (p < 0.01, p < 0.01), CAT (p < 0.01, p < 0.01), SOD (p < 0.01, p < 0.01), Zn (p < 0.001, p < 0.01), serum retinol (p < 0.01), α-tocopherol (p < 0.001), increased PCO (p < 0.01, p < 0.01), MDA (p < 0.001, p < 0.05), Cu (p < 0.05, p < 0.05), and Cu/Zn (p < 0.001, p < 0.001) PRP exposure in compared to control group. The results showed that the TQD and A. spicigera exhibited effective antioxidant and antihemolytic activity. This suggests that A. spicigera and TQD may reduce many of the oxidative-damaging effects of PRP toxicity and could be a good choice for protecting against the nephrotoxic, hepatotoxic, and hematotoxic adverse effects of propanil. In addition, PCO, CAT, SOD, GSH, Cu, and Cu/Zn were proposed as bioindicators of environmental contaminants for propanil-induced oxidative damage
