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Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian mother, father, and child cohort study
Get PDFBackground
Telomere length (TL) has been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, with some studies finding associations with shorter TL and others with longer TL. In men, studies mostly report associations between shorter TL and sperm quality. To our knowledge, no studies have thus far investigated associations between TL and fecundability or the use of assisted reproductive technologies (ART).
Methods
This study is based on the Norwegian Mother, Father, and Child Cohort (MoBa) Study and uses data from the Medical Birth Registry of Norway (MBRN). We included women (24,645 with genotype data and 1054 with TL measurements) and men (18,339 with genotype data and 965 with TL measurements) participating between 1998 and 2008. We investigated associations between leukocyte TL (LTL) and fecundability (defined as the probability to conceive within a given menstrual cycle), infertility (defined has having spent 12 months or more trying to conceive without success), and ART use. We also repeated the analyses using instrumental variables for LTL consisting of genetic risk scores for LTL and genetically predicted LTL.
Results
Approximately 11% of couples had experienced infertility and 4% had used ART. LTL was not associated with fecundability in women (fecundability ratio [FR], 0.98; 95% confidence interval [CI], 0.92–1.04) or men (FR, 0.99; CI, 0.93–1.06), nor with infertility in women (odds ratio [OR], 1.03; CI, 0.85–1.24) or men (OR, 1.05; CI, 0.87–1.28). We observed an increased likelihood of using ART with increasing LTL in men (OR, 1.22; CI, 1.03–1.46), but not in women (OR, 1.10; CI, 0.92–1.31). No significant associations were observed using the instrumental variables for LTL.
Conclusions
We found no indication that LTL is a suitable biomarker for assessing fecundability, infertility, or ART use. Additional studies are required to replicate the association observed between LTL and ART use in men.info:eu-repo/semantics/publishedVersio
Semiparametric modeling for the cardiometabolic risk index and individual risk factors in the older adult population: A novel proposal
Get PDFThe accurate monitoring of metabolic syndrome in older adults is relevant in terms of its
early detection, and its management. This study aimed at proposing a novel semiparametric
modeling for a cardiometabolic risk index (CMRI) and individual risk factors in older adults.
Methods: Multivariate semiparametric regression models were used to study the associa-
tion between the CMRI with the individual risk factors, which was achieved using secondary
analysis the data from the SABE study (Survey on Health, Well-Being, and Aging in Colom-
bia, 2015). Results: The risk factors were selected through a stepwise procedure. The
covariates included showed evidence of non-linear relationships with the CMRI, revealing
non-linear interactions between: BMI and age (p< 0.00); arm and calf circumferences
(p<0.00); age and females (p<0.00); walking speed and joint pain (p<0.02); and arm circum-
ference and joint pain (p<0.00). Conclusions: Semiparametric modeling explained 24.5% of
the observed deviance, which was higher than the 18.2% explained by the linear model.info:eu-repo/semantics/publishedVersio
Responsible Internet use and digital safety: systematic review on educational programs
Get PDFEl objetivo de esta revisión sistemática fue analizar los programas educativos que abordan el uso responsable de Internet para gestionar los diversos retos y riesgos del espacio digital. Se utilizaron 5 bases de datos para obtener estudios realizados entre 2017 y 2022. Se analizaron las siguientes variables: población diana, duración, contenido y evaluación. Los programas abordaban los siguientes riesgos en línea: ciberacoso, sexting, privacidad digital, grooming, suplantación de identidad, información falsa, uso problemático de Internet, phishing e ingeniería social, identidad digital, compartir excesiva información, spam y fraude. Se ha identificado la necesidad del diseño e implementación de programas que involucren a toda la comunidad educativa y aborden las problemáticas del consumo de pornografía y la seguridad online.The objective of this systematic review was to analyze pre-existing programs that address a re-sponsible use of the Internet with the aim of manag-ing the diverse challenges and risks of the digital space. Five databases were used to obtain studies from 2017 to 2022. The following variables were analyzed: target population, duration, content, and evaluation. Pro-grammes included the following online risks: cyberbul-lying, sexting, digital privacy, grooming, identity theft, false information, problematic Internet use, phishing and social engineering, digital identity and online rep-utation, excessive information sharing, spam and and fraud. The need for the design and implementation of programs that involve the entire educational commu-nity and address the issues of pornography and online safety has been identified.info:eu-repo/semantics/publishedVersio
From heritage tourism to sun and beach destinations: The explanatory role of enviromental factors on the average daily rate.
No full textPurpose - This study aims to analyse whether the impact of external factors on the average daily rate (ADR) varies according to the type of destination. The study measures the effects of length of stay, share of international tourism and seasonality on hotel rates for sun and beach tourism, city tourism and heritage destinations. Methodology/Design/Approach - We collected monthly data from January 2021 to June 2023 and conducted a regression analysis to measure how international tourism, length of stay or seasonality differ by destination type and what impact these factors have on ADR. The data refers to the 106 tourist destinations defined by the Spanish Statistics Institute (INE). Findings - Increasing the length of stay has a positive effect on ADR for cultural heritage destinations. In all types of destinations, a higher share of international tourism increases ADR, but the effect is particularly strong for city tourism. Greater seasonality is associated with higher hotel prices and is particularly relevant for sun and beach destinations. Originality of the research -A better understanding of ADR determinants, depending on the different destination types, is important for hotel managers and those designing tourism policies at destination level.info:eu-repo/semantics/publishedVersio
Hilando el futuro de Roberto Verino: propuesta estratégica de comunicación de la marca (2024-2025)
No full textTFM del Màster universitari en Estratègia i Creativitat Publicitàries. Tutoritzat per Víctor Curto GordoEl presente Trabajo Final de Máster se centra en el desarrollo de un plan estratégico para la marca Roberto Verino. En este sentido, se busca comprender a fondo la trayectoria, los valores y el posicionamiento actual de la marca, así como identificar oportunidades de crecimiento en el mercado español. A través de un análisis exhaustivo del entorno competitivo, las tendencias del sector y las preferencias del consumidor, se pretende diseñar un plan estratégico que permita a Roberto Verino alcanzar sus objetivos.info:eu-repo/semantics/publishedVersio
Intervención cognitivo conductual en un grupo de adolescentes con Trastornos de la Conducta Alimentaria: Un estudio de caso
Get PDFTFM del Màster Universitari en Psicologia General Sanitària tutoritzat per Meritxell Pacheco PérezEl objetivo principal de este estudio es el análisis y seguimiento de una intervención
cognitivo conductual con un grupo de adolescentes entre 13 y 15 años, que tienen un
diagnóstico de trastorno de la conducta alimentaria. Los principales temas tratados durante
las sesiones fueron: la insatisfacción corporal, la presión social, el autoconocimiento, la
autoestima, el autoconcepto, las emociones, la relación con familia e iguales y el
funcionamiento social. Se realizaron 11 sesiones grupales semanalmente en el contexto del
centro de salud mental infanto-juvenil al que asistían una o dos veces al mes para visitas con
la enfermera y/o psicóloga referente. Los resultados obtenidos a través del análisis de cada
sesión y de la prueba psicológica EDI 3 aplicada antes de empezar y al finalizar el grupo nos
muestran que, al concluir la intervención, las pacientes mostraban un mejor perfil que antes
de comenzar. Concluimos que a pesar de las dificultades que tenían debido al trastorno y del
rechazo al grupo que muchas presentaban antes de comenzar, se pudo trabajar de manera
satisfactoria, intentando que el espacio del grupo sea un lugar seguro y lo más ameno posible
para ellas. Esto fue esencial para poder trabajar en las sesiones, mejorar algunas de las escalas
psicológicas afectadas en un inicio y conseguir los objetivos del tratamiento.The primary goal of this study is to analyze and track a cognitive-behavioral intervention
among a group of adolescents aged 13 to 15 diagnosed with an eating disorder. The key
themes addressed during the sessions include body dissatisfaction, social pressure, selfawareness, self-esteem, self-concept, emotions, family and peer relationships, and social
functioning. Weekly group sessions, totaling 11, were conducted within the child and
adolescent mental health center. Participants also attended the center once or twice a month
for visits with the nurse and/or referring psychologist. The analysis of each session and the
EDI 3 psychological test administered before and after the group sessions reveals that, by the
end of the intervention, the patients demonstrated and improved profile compared to their
initial state. In conclusion, despite initial difficulties stemming from the disorder and
resistance from some participants before the commencement of the group, the sessions were
successfully conducted. The emphasis was on creating a safe and enjoyable environment
within the group space. This approach proved essential in facilitating sessions, addressing
initial psychological scale challenges, and achieving the treatment objectives
Sex differences in the effects of N-ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression
Get PDFBackground and purpose: New psychoactive substances such as N-ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study compares some key effects of NEP in male and female mice.
Experimental approach: Psychostimulant, rewarding and reinforcing effects were investigated by tracking locomotor activity, conditioned place preference (CPP) paradigm and through a self-administration (SA) procedure, respectively, in CD1 mice. Moreover, the expression of early genes (C-fos, Arc, Csnk1e, Pdyn, Pp1r1b and Bdnf in addiction-related brain areas) was assessed by qPCR. Finally, serum and brain levels of NEP were determined by UHPLC-MS/MS.
Key results: NEP-treated males experimented locomotor sensitisation and showed higher and longer increases in locomotion as well as higher hyperthermia after repeated administration than females. Moreover, while preference score in the CPP was similar in both sexes, extinction occurred later, and reinstatement was more easily established for males. Female mice self-administered more NEP than males at a higher dose. Differences in early gene expression (Arc, Bdnf, Csnk1e and Ppp1r1b) were found, but the serum and brain NEP levels did not differ between sexes.
Conclusion and implications: Our results suggest that male mice are more sensitive to NEP psychostimulant and rewarding effects. These differences may be attributed to different early gene expression but not to pharmacokinetic factors. Moreover, males appear to be more vulnerable to the hyperthermic effects of NEP, while females might be more prone to NEP abuse.info:eu-repo/semantics/publishedVersio
Size-selective trapping and photocatalytic degradation of PFOA in Fe-modified zeolite frameworks
Get PDFRemoval and destruction of perfluorooctanoic acid (PFOA) are challenging due to its extreme persistence and dilute concentrations. This study investigated dual-function adsorptive-photocatalytic zeolite materials to selectively adsorb and degrade PFOA via tuning pore structures and doping transition metals. It is found that the pore opening is critical in the size-selective trapping of PFOA, while the iron doped zeolites present excellent adsorption of PFOA (>80 mg g−1) combining hydrophobic and electrostatic interactions. The formation of PFOA-iron complexes has reduced bond dissociation energy of C−F, calculated from density functional theory, for favorable stepwise defluorination (over 60% defluorination in 4 hours) by superoxide radicals and ligand-to-metal charge transfer. This mechanistic investigation extends the potential of the concentrate-and-degrade concept to remove PFOA selectively and effectively from contaminated water.info:eu-repo/semantics/publishedVersio
Viladecans City Curriculum
Get PDFEl treball del currículum de ciutat de Viladecans és una oportunitat per
connectar totes les experiències educatives dins d'un territori. Aquesta proposta
busca consensuar competències transversals entre diversos agents educatius per
crear un ecosistema educatiu local integral i coordinat. Destaca la importància de la
col·laboració entre sectors, l'enfocament integral de l'educació, la promoció de
competències transversals i l'adaptació local. En conclusió, representa un pas cap a
un sistema educatiu més col·laboratiu i centrada en competències clau.El trabajo del currículum de ciudad de Viladecans es una oportunidad
para conectar todas las experiencias educativas dentro de un territorio. Esta
propuesta busca consensuar competencias transversales entre diversos agentes
educativos para crear un ecosistema educativo local integral y coordinado. Destaca
la importancia de la colaboración entre sectores, el enfoque integral de la educación,
la promoción de competencias transversales y la adaptación local. En conclusión,
representa un paso hacia un sistema educativo más colaborativo y centrado en
competencias clave.The Viladecans City Curriculum initiative provides an opportunity to
connect all educational experiences within a territory. This proposal aims to agree
upon cross-cutting competencies among various educational stakeholders to create
a comprehensive and coordinated local educational ecosystem. It emphasizes the
importance of collaboration across sectors, a holistic approach to education, the
promotion of cross-cutting competencies, and local adaptation. In conclusion, it
represents a step towards a more collaborative educational system focused on key
competenciesinfo:eu-repo/semantics/publishedVersio
High-Compression Crash Simulations and Tests of PLA Cubes Fabricated Using Additive Manufacturing FDM with a Scaling Strategy
Get PDFImpacts due to drops or crashes between moving vehicles necessitate the search for energy absorption elements to prevent damage to the transported goods or individuals. To ensure safety, a given level of acceptable deceleration is provided. The optimization of deformable parts to absorb impact energy is typically conducted through explicit simulations, where kinetic energy is converted into plastic deformation energy. The introduction of additive manufacturing techniques enables this optimization to be conducted with more efficient shapes, previously unachievable with conventional manufacturing methods. This paper presents an initial approach to validating explicit simulations of impacts against solid cubes of varying sizes and fabrication directions. Such cubes were fabricated using PLA, the most used material, and a desktop printer. All simulations could be conducted using a single material law description, employing solid elements with a controlled time step suitable for industrial applications. With this approach, the simulations were capable of predicting deceleration levels across a broad range of impact configurations for solid cubes.info:eu-repo/semantics/publishedVersio