Hacettepe University Reserach Information System
Not a member yet
118745 research outputs found
Sort by
Factors effecting the success of retrograde tibiopedal access and recanalization in infrapopliteal artery occlusions
No full textPURPOSE: Peripheral arterial disease (PAD) is increasingly prevalent, particularly among the aging population. Retrograde tibiopedal access (RTPA) has emerged as a useful endovascular treatment for PAD. However, there is limited research examining factors that influence the efficacy of RTPA. To investigate factors affecting the access, crossing, and recanalization success rates of RTPA for infrapopliteal PAD treatment. METHODS: A retrospective study was conducted on 720 patients who underwent endovascular treatment for PAD. Of these, 104 patients (mean age: 65.5 ± 16.2; 89 men) with 131 RTPA trials were included in the final evaluation. The disease and its duration, Rutherford score, smoking status, access site, and its occlusion status, access, crossing, and recanalization success were noted. Data were analyzed using Pearson’s chi-square and Mann–Whitney U tests and multivariate logistic regression to evaluate the impact of various factors on success rates. RESULTS: The access success rate was 82.6%, the crossing success rate was 95.4%, and the recanalization success rate was 74%. Access success was significantly higher when the dorsal pedal artery (DPA) was the access artery compared with the posterior tibial artery (91.3% vs. 74.2%, P = 0.009). Access success was notably lower in patients with thromboangiitis obliterans compared with patients with diabetes mellitus (DM) and non-DM atherosclerosis (68.6% vs. 90.3% and 80.3%, P = 0.019). Recanalization success was higher when the puncture site was non-occluded (76.7% vs. 53.5%, P = 0.023). CONCLUSION: The study suggests that RTPA is a generally effective and safe technique for infrapopliteal PAD treatment. The most favorable outcomes are observed in individuals with DM who have a non-occluded DPA at the puncture site. Recanalization success is only affected by the patency of the artery at the puncture site. CLINICAL SIGNIFICANCE: These findings offer targeted guidance for clinicians and highlight areas requiring further investigation
THE MEDIATING ROLE OF JOB STRESS IN THE EFFECT OF PERCEIVED MUSHROOM MANAGEMENT ON INTENTION TO QUIT
No full textValidation of the EULAR/ACR classification criteria for chronic nonbacterial osteomyelitis in a pediatric cohort
No full textObjectivesChronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder primarily affecting children and adolescents. An international consensus group developed the EULAR/ACR Classification Criteria in order to define a homogeneous group of patients diagnosed with CNO. This study aims to validate these criteria in a diverse pediatric cohort and compare their performance with the Jansson and Roderick diagnostic criteria.MethodsA retrospective evaluation was conducted on 78 pediatric CNO patients and 99 mimickers in Hacettepe University department of pediatric Rheumatology from 2020 to 2024. Demographic, clinical, laboratory, and imaging data were analyzed, and the sensitivity, specificity, and predictive values of the EULAR/ACR criteria were assessed. Statistical comparisons were made against the Jansson and Roderick criteria.ResultsThe EULAR/ACR criteria demonstrated high accuracy, with a sensitivity of 92.68% and specificity of 97.89%, outperforming the Jansson criteria (sensitivity: 88.46%, specificity: 72.73%) and aligning closely with the Roderick criteria (sensitivity: 96.15%, specificity: 96.97%). Key distinguishing features included multifocal and symmetric lesions, frequent involvement of high-scoring anatomical sites (e.g., clavicle and mandible), and the absence of exclusion criteria such as fever and markedly elevated inflammatory markers.ConclusionsThe newly validated EULAR/ACR classification criteria for pediatric CNO demonstrated high specificity and good sensitivity in our cohort. Their application facilitates the identification of homogeneous patient populations, aiding in research consistency and the development of standardized approaches to CNO classification and management.Key Points center dot The EULAR/ACR classification criteria for pediatric CNO exhibited high specificity (97.89%) and sensitivity (92.68%), supporting their validity.center dot Multifocal and symmetric bone lesions, particularly in the clavicle and mandible, strongly support classification under these criteria.center dot Validation in a pediatric cohort reinforces their utility for standardized patient classification and research consistency.ConclusionsThe newly validated EULAR/ACR classification criteria for pediatric CNO demonstrated high specificity and good sensitivity in our cohort. Their application facilitates the identification of homogeneous patient populations, aiding in research consistency and the development of standardized approaches to CNO classification and management.Key Points center dot The EULAR/ACR classification criteria for pediatric CNO exhibited high specificity (97.89%) and sensitivity (92.68%), supporting their validity.center dot Multifocal and symmetric bone lesions, particularly in the clavicle and mandible, strongly support classification under these criteria.center dot Validation in a pediatric cohort reinforces their utility for standardized patient classification and research consistency
Cradled by architecture: infancy and delayed personhood in Neolithic Anatolia and the Balkans
No full textChildren, especially infants, are integral to human communities, but how they are perceived varies across societies. This study examines infancy at the late seventh millennium Neolithic sites of Barc & imath;n H & ouml;y & uuml;k and Lepenski Vir through the concept of delayed personhood, namely the belief that young children were partially or not yet recognized as persons. Both sites provide extensive data on burial locations, including age, sex, and biological relatedness. Infant burials show a strong spatial association with architectural structures, suggesting a distinct funerary practice from adults. While infant burial associated with houses may imply a link to homes, the evidence from both sites suggests burial according to age rather than genetic proximity. Therefore, our study suggests that delayed personhood was expressed after death through the cradling of infants by architecture, indicating that infants could have been community members, and that kin-making may have extended to 'not-yet-fully human' beings during the Neolithic
The role of non-coding RNAs miR-98, miR-19a and lncRNA MALAT1 and oxidative stress in the pathogenesis of food allergy
No full textBackground. Food allergy is a public health concern affecting quality of life and increasing in prevalence. Numerous studies suggest that the rapid increase in the prevalence of allergic diseases may be linked to epigenetic mechanisms, particularly microRNA (miRNA), long non-coding RNA (lncRNA). The aim of this study was to investigate the effects of oxidative stress and selected non-coding RNAs on the development and pathogenesis of food allergy. Methods. A total of 26 children with food allergy and 30 healthy children were enrolled in this study. Real-time polymerase chain reaction (RT-PCR) was performed to detect the expressions of serum miR-19a, miR-98 and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in all the participants. Serum levels of interleukin-4 (IL-4), IL-10, IL-13 and transforming growth factor beta (TGF-beta), along with levels of oxidative stress markers 8-isoprostane and cysteinyl leukotrienes, were measured by enzyme-linked immunosorbent assay. Results. Our study found that the expression of miR-98 was significantly lower in children with food allergies compared to healthy controls (p 0.05). There was no difference in gene expression levels (p > 0.05) of lncRNA MALAT1 between children with food allergies and healthy children. TGF-beta levels of healthy children were found to be significantly higher than those of children with food allergies (p < 0.05). There was no statistical difference in cysteinyl leukotriene levels between patients and controls (p = 0.804). However, 8-isoprostane levels were significantly lower in patients (6.68 pg/mL; interquartile range [IQR]: 1.57-26.55) compared to controls (37.20 pg/mL, IQR: 18.55-167.58) (p < 0.001). Conclusions. Considering our findings in conjunction with existing literature, miR-98 appears to be a promising candidate biomarker for food allergy
Mezuniyet Sonrasında Doğrudan Meslek İcra Yetkisi Veren Sağlık Meslek Mensubu Yetiştiren Programlarda Asgari Başarı Sırası Koşulunun Değerlendirilmesi: Tematik Analiz
No full textAmaç: Bu araştırma makalesinde Yükseköğretim Kurumları Sınavı (YKS)-2022-2023 ve 2024’e göre Türkiye’de Sağlık Bilimleri alanında eğitim veren lisans programlarına yerleşenlerin taban başarı sıralamaları ve bu sıralamalara göre Sağlık Meslek Mensubu olan programlar için Asgari Başarı Sırası Koşulu getirilmesi konusu üzerinde bir tematik analiz yapılmıştır. Bireyler ve Yöntem: Sağlık Meslek Mensubu olan ve olmayan Sağlık Bilimleri programlarına YKS-2022, 2023 ve 2024 yıllarında en yüksek ve en düşük Taban Başarı Sıralaması’na göre yerleşen son adayların yerleştikleri üniversiteler ve sıralamaları YÖK Lisans Atlası Tercih Sihirbazı sayfasından, en yüksek ve en düşük Taban Başarı Sıralaması’na göre yerleşen son adayların TYT (Temel Yeterlilik Testi) ve AYT (Alan Yeterlilik Testi) net sayılarına ilişkin bilgiler YÖK Lisans Atlası TYT-AYT Net Sihirbazı Atlası’ndan alınmış, net sayılarının yüzdeye çevrilmesinde sayısal puan türleri için belirlenmiş ağırlıklar ile Asgari Başarı Sıralaması Koşulu değerlendirilirken Taban Başarı Sıralamaları için 200.000, 250.000 ve 300.00 kesim noktaları kullanılmıştır. Bulgular: Sağlık Meslek Mensubu programları arasında en yüksek Taban Başarı Sıralaması’na sahip program Dil ve Konuşma Terapisi’dir. En yüksek ve en düşük Taban Başarı Sıralaması arasındaki fark tüm yıllarda Beslenme ve Diyetetik programları için 1.422.937, Hemşirelik programları için 1.422.475, Fizyoterapi ve Rehabilitasyon programları için 1.396.564 kişiye kadar yükselmiştir. Asgari Başarı Sıralaması Koşulu’nın 200.000 olduğunda TYT sorularının ~%50’si, AYT sorularının ise ~%30’u doğru yanıtlanmış olacaktır. Sonuç: Sağlık Meslek Mensubu olan Beslenme ve Diyetetik, Dil ve Konuşma Terapisi, Ebelik, Ergoterapi, Fizyoterapi ve Rehabilitasyon, Hemşirelik, Odyoloji ve Perfüzyon programları için Asgari Başarı Sıralaması Koşulu’nun getirilmesi ve bunun 200.000 olması önerilmektedir.Aim: In this research article, a thematic analysis was conducted on the minimum success rank condition to be applied for programs that qualify as Health Professionals, based on the minimum placement success ranks of undergraduate programs in the field of Health Sciences in Turkey according to the Higher Education Institutions Exam (YKS) results from 2022, 2023, and 2024. Subjects and Method: The universities and rankings of the last candidates who were placed according to the highest and lowest Base Success Rankings in the Health Sciences programs with and without Health Professionals in YKS-2022, 2023, and 2024 were obtained from the YÖK Undergraduate Atlas Preference Wizard page. Information regarding the number of TYT (Basic Proficiency Test) and AYT (Field Proficiency Test) correct answers of the last placed candidates according to the highest and lowest Base Success Rankings was obtained from the YÖK Undergraduate Atlas TYT-AYT Net Wizard. In converting the number of correct answers into percentages, the weights determined for the numerical score types were used, and while evaluating the Minimum Success Ranking Condition, cutoff points of 200,000, 250,000, and 300,000 were applied for the Base Success Rankings. Results: Among Health Professionals Programs, the program with the highest Minimum Success Ranking is Speech and Language Therapy. The difference between the highest and lowest Minimum Success Rankings has reached up to 1,422,937 people for Nutrition and Dietetics programs, 1,422,475 people for Nursing programs, and 1,396,564 people for Physiotherapy and Rehabilitation programs across all years. When the Minimum Success Ranking Condition is 200,000, approximately 50% of the TYT questions and about 30% of the AYT questions will have been answered correctly. Conclusion: The proposed condition is to set a Minimum Success Ranking Requirement of 200,000 for the Health Professionals Programs such as Nutrition and Dietetics, Speech and Language Therapy, Midwifery, Occupational Therapy, Physiotherapy and Rehabilitation, Nursing, Audiology, and Perfusion
