Hacettepe University Reserach Information System
Not a member yet
118745 research outputs found
Sort by
Intentions of hospital pharmacists to use digital technology in their daily practice: a cross-sectional survey using the Theory of Planned Behaviour
No full textBackground Digital technology has been widely integrated into healthcare. This encompasses knowledge, skills, and practices related to the development and use of health technologies. The behavior of health professionals is critical to the adoption of these technologies. Aim This study aimed to investigate factors associated with hospital pharmacists' intention to use digital technology in their daily practice using the Theory of Planned Behaviour (TPB). Method In this cross-sectional study, a paper-based survey was conducted among hospital pharmacists who attended the National Hospital Pharmacy Congress in T & uuml;rkiye in March 2022. A valid and reliable Turkish scale based on the TBP was used to identify factors associated with the intention score by a multiple linear regression model. Results One hundred ten participants completed the survey (response rate: 44.0%). Seventy percent of pharmacists reported that they had not received prior training in digital technologies. More than eighty percent of the participants said they intend to use digital technology in daily practice. The higher scores of attitudes (p = 0.005), self-efficacy (p < 0.001), and working place (p = 0.017) were associated with increased intention scores. Conclusion Positive attitudes, higher self-efficacy, and working in tertiary hospitals were associated with hospital pharmacists' intentions to use digital technology in daily practice. These factors should be considered in developing interventions to promote digital technology use of hospital pharmacists
Comparison of children and adolescents diagnosed with attention deficit hyperactivity disorder with and without autism traits in terms of emotion regulation, clinical characteristics and functionality
No full textThis study aims to demonstrate that children and adolescents diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) who exhibit autism traits have a more severe clinical profile in terms of emotion regulation, clinical features related to ADHD, and functionality, compared to those diagnosed with ADHD without these traits. 50 patients with and 64 patients without autism traits between the ages of 8-16 were recruited for the study among the children and adolescents diagnosed with ADHD. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5-2016-Turkish Adaptation (K-SADS-PL-DSM-5-T) was used to exclude the diagnosis of Autism Spectrum Disorder (ASD) and detect comorbid psychiatric diagnosis. The Social Reciprocity Scale (SRS) was completed by parents to determine groups based on autism traits. Children completed the Childhood Anxiety Sensitivity Index (CASI) and the Affective Reactivity Index (ARI). The Strengths and Difficulties Questionnaire (SDQ), Affective Reactivity Index-Parent Report (ARI-P) and Weiss Functional Impairment Rating Scale-Parent Report (WFIRS-P) were completed by the parents. We found that the group with autism traits had significantly more hyperactivity/inattention, conduct problems, emotional problems, and peer problems and significantly more irritability and frequent separation anxiety disorder. Although there was no significant impairment in functionality in either group, the level of impairment was significantly higher in the group with autism traits. Children diagnosed with Attention Deficit Hyperactivity Disorder who exhibit autism traits experience higher levels of irritability and separation anxiety disorder, as well as greater impairment in functionality, compared to those without these traits
Extracorporeal Shock Wave Therapy (ESWT) vs. Exercise in Thumb Osteoarthritis (SWEX-TO): Prospective Clinical Trial at 6 Months. <i>Life</i> 2024, <i>14</i>, 1453
No full textMultidisciplinary Tumor Board Evaluation of Pediatric Patients with Adrenocortical Tumors Across Seven International Centers
No full textBackground: The management of rare tumors at reference centers with specialized multidisciplinary tumor boards (MTBs) improves patient survival. No international standardized diagnostic and treatment recommendations for pediatric patients with adrenocortical carcinoma (ACC) exist so far. The aim of this case-based study is to determine how congruent treatment recommendations are in different specialized institutions in different countries. Methods: In this cross-sectional, case-based survey study, five anonymized patient cases, including imaging data of pediatric adrenocortical carcinomas (pACCs), were distributed to seven international specialized centers located in Brazil, Germany, India, Italy, Poland, Turkey, and the USA. The centers were tasked with providing recommendations regarding the treatment sequence and modalities, as well as indicating the level of consensus on these decisions within their MTBs. For each case, the treatment approach recommended by the highest number of centers was recorded to calculate an agreement percentage relative to all treatment recommendations made. The consensus level for each case was determined on a scale of 1 to 10, with higher scores indicating greater agreement among MTB members. Results: A total of five patient cases were discussed across seven MTBs, yielding a total of 34 treatment recommendations. The agreement percentages for the primary therapeutic approach for each case were as follows: primary therapeutic approach: 88.6%; surgical approaches: 51.8%; and systemic chemotherapy recommendations: 53%. Conclusions: This study represents the first case-based analysis of international inter-center agreement on pediatric ACC management. Inter-center agreement regarding treatment allocation and sequencing was low, while the level of consensus within each MTB was high. These findings point to potentially significant and clinically relevant differences in treatment standards across centers, highlighting the need for international collaboration and standardized diagnostic and therapeutic recommendations, especially for rare tumors. Increased case-based exchanges between centers are essential to reduce the substantial discrepancies observed here and to further standardize the management of pediatric patients with ACC
Energy Entrepreneurship, Sustainability, Innovation and Financing
No full textThe activities of renewable energy (RE) sector entrepreneurs, who carry out their activities against the adverse effects of climate change, are of interest to academics and practitioners worldwide to make them effective and sustainable. Sustainable entrepreneurship activities in the RE sector aim to provide strategies and solutions to alleviate current and future generations’ economic, social, and ecological concerns. Living today while not endangering the lives of future generations requires a globally established awareness. Maximizing economic well-being, environmental resilience, and social equity are the long-term priorities of all societies. Therefore, researchers are responsible for disseminating sustainable-oriented entrepreneurial activities in the RE sector in developing countries. However, only some studies have examined entrepreneurial activities in the RE sector, especially in developing countries. The present study presents a systematic and comprehensive literature review to address this gap. The aim of this study is threefold: to examine the sustainable entrepreneurship and renewable energy sector literature in various scopes, approaches, and contexts, to address the challenges experienced by renewable energy sector entrepreneurs in developing countries, and to outline a framework for multiple factors including motivating factors for entrepreneurs, institutional supports, challenges, barriers, incentives from international development organizations and reasons for failure.</p
Development of the all-solid-state flexible supercapacitor membranes <i>via</i> RAFT-mediated grafting and electrospun nanofiber modification of track-etched membranes
No full textDeveloping novel membranes marks a significant advancement in flexible energy storage systems. In this work, a hybrid track-etched membrane (TeM) was synthesized through RAFT-mediated polymerization, where poly(acrylic acid) (PAA) was grafted onto both the nanopore walls and surface of PET-based TeMs (PET-g-PAA), creating a stable and functionalized matrix for further enhancements. The membrane was then modified by incorporating electrospun composite nanofibers made from poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) as the polymer matrix, ionic liquid (1-ethyl-3-methylimidazolium tetrafluoroborate, EM-IMBF4) as the supporting electrolyte, and graphene oxide (GO) as the ionic conductivity enhancer. The nanofibers (PVDF-HFP_GO) were deposited on either one or both surfaces of the grafted membrane. These modifications substantially improved the membrane's active surface area, porosity, and electrochemical performance, positioning it as a strong candidate for flexible energy storage applications. Comprehensive characterizations verified the successful modification and enhanced properties, including FTIR, SEM-EDX, XPS, TGA, porosity analysis, and contact angle measurements. Electrochemical performance was evaluated through cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectroscopy (EIS). Among the tested membranes, the one modified with 0.5% GO-containing nanofibers demonstrated the highest capacitance and coulombic efficiency. Although the membrane showed strong charge/discharge efficiency and high initial performance, performance degradation was observed after extended cycling, particularly at higher current densities. The ionic conductivity of the hybrid membranes (with a GO concentration of 0.5%) reaches 14.83 x 10-3 mS cm-1 for single-sided nanofiber-covered membranes and 39.08 x 10-3 mS cm-1 for double-sided nanofiber-covered membranes, while for similar samples without addition of GO this values were found to be of 1.42 x 10-3 mS cm-1, which is significantly higher than conventional polymer-based electrolyte membranes (similar to 10-4 to 10-2 mS cm-1), and comparable to advanced ionic gel-based systems (similar to 10-2 to 10-1 mS cm-1). The synergistic effects of PAA grafting and PVDF-HFP_GO fibers delivered competitive charge/discharge efficiency when compared to similar systems, though further optimization of current density and cycling stability is required. This study highlights the potential of combining the RAFT-mediated grafting technique with electrospun composite nanofibers in modifying TeMs to develop durable and flexible supercapacitor membranes with promising electrochemical performance
Evaluation of hard tissue characteristics and calcifications in pulp tissue of hypomineralized permanent molars using micro-computed tomography
No full textObjectives: To determine and compare pulp volume, dentin mineral density, presence of microcracks, pulp stones, and accessory canals, as well as their localizations in root regions for hypomineralized and healthy teeth. Design: This study included 60 extracted permanent molar teeth, categorized into hypomineralized and healthy groups (n = 30 each). The hypomineralized group comprised molar teeth with limited white, yellow, or brown opacities, post-eruptive breakdown, or extensive restoration or crown damage. The healthy group included caries-free molar teeth without these characteristics. Using 3D micro-computed tomography images pulp volume, dentin mineral density, and the presence and locations of microcracks, pulp stones, and accessory canals were determined for each group. Statistical analyses were conducted using Independent T-test and Chi-square test, with significance set at p = 0.05). The number of accessory canals was significantly greater in the cervical (p = 0.011; p < 0.05) and middle (p = 0.010; p < 0.05) regions of the hypomineralized teeth than healthy teeth. Dentin mineral density was statistically higher in the apical, middle, and cervical root regions (p < 0.001; p < 0.05); however, the number of pulp stones was found to be greater in the cervical regions of healthy teeth compared with those with hypomineralization (p = 0.026; p < 0.05). Conclusion: There were lower dentin mineral density measurements, a decreased number of pulp stones in the cervical region, and a greater number of accessory canals in the middle and cervical regions of hypomineralized teeth compared with healthy teeth
