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Mapping the Evolution of Evidence-Based Teaching in Science Education: A Bibliometric Approach
No full textSome Polyphenolic Compounds as Potential Therapeutic Agents in Cervical Cancer: The Most Recent Advances and Future Prospects
No full textThe leading causes of cancer include gradual changes in regulatory proteins, dysregulated cell-signaling pathways, dysfunction of apoptosis, and oxidative stress. Consuming polyphenols from food sources has been proven to have strong connections with ameliorating specific physiological biomarkers along with other elements concerning cancer. Recent studies have focused on polyphenols' molecular mechanisms of action and anticancer and chemopreventive properties and effects in the treatment of different types of cancer. Polyphenols participate in the regulation of numerous cellular mechanisms alongside signaling pathways through their effects on inflammation, cellular proliferation, apoptosis, and partially via epigenetic alterations in cervical cancer. A number of animal models and cell and human studies have indicated the use of polyphenols to be safe and tolerable. Thus, it would be fair to state that, with their advantages vis-& agrave;-vis lack of toxicity, cost, and access, and with the positive clinical results, polyphenols have a potential to make a difference in cancer treatment. The present review examined the chemical and physical properties, analogs, metabolites, and mechanisms of physiological activities of various polyphenols and how they may affect the incidence rate and management of cervical cancer. Therefore, this review constitutes a starting point to examine the potential applications for cervical cancer
Microbial ecology of sandflies-the correlation between nutrition, <i>Phlebotomus papatasi</i> sandfly development and microbiome
No full textThe role and the impact of the microbial component on the biology, ecology, and development of sandflies is largely unknown. We evaluated the impact of larval nutrition on laboratory-reared sandflies in correlation to the abundance of food, light starvation, and food with/without live microbiome, by monitoring the survival and development of immature stages, and the longevity of adult sandflies. Within this study we examined 360 larvae, 116 pupae, and 120 adult flies of Phlebotomus papatasi for the microbial gut content. The data showed that the presence of a live and diverse microbiome plays a role in the development and survival of larvae. The mortality rate of the larvae was higher, and larval development was longer for sandflies maintained on microbiome-depleted medium, in comparison to the larvae fed with medium containing alive and complex microbiome. Actively feeding larvae reduce microbial abundance and diversity of the medium. The microbial content of the larval gut depends on the composition of the rearing medium, indicating a potential attraction to certain bacteria. The microbial content of the pupa gut was severely diminished, with overall survival of two bacterial species in adult insects - Ochrobactrum intermedium (found in 95% of dissected adults) and Bacillus subtilis (16%). Further microbial studies may aid in developing biological control methods for sandfly larval or adult stages
Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry
No full textObjective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma. Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared. Results: The obesity rate in TAAR was 32.2% (n=619/1919; 18-83years; 527F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%. Conclusions: A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control
Editorial to "Carbon dioxide insufflation to facilitate epicardial access in extracorporeal membrane oxygenation-supported ventricular tachycardia ablation": Blowing an exhaled gas for easy and safe pericardial puncture.
No full textMathematical Albumin Function for Neonates Undergoing Therapeutic Hypothermia in Comparison with Control Neonates.
No full textEtch-and-rinse vs self-etch strategy of a universal adhesive in Class II bulk-fill restorations: A 96-month split-mouth evaluation.
No full textA Comparative Study of Anticipatory Grief in Caregivers of Patients With Alzheimer's Disease and Hematological Malignancy
No full textBackground: Anticipatory grief (AG) is a common experience that affects caregivers of patients with chronic illnesses, particularly Alzheimer's disease. Cognitive disorders leading to social death produce a greater impact on the relationship, and thus on AG, than physical disorders. Objective: The purpose of this study is to examine the prevalence and severity of AG in caregivers of patients with major neurocognitive disorder due to Alzheimer's disease (MNCD-AD) compared to hematological malignancies and to identify the characteristics associated with AG. Methods: A total of 132 dyads (patients and their caregivers) completed measures of AG, caregiver burden, anxiety, and depressive symptoms, as well as mental status. Results: The point prevalence of significant AG was similar in the MNCD-AD (57.6%) and hematological malignancy (51.5%) groups. There was no statistically significant difference between the groups in terms of the severity of AG (48.77 +/- 17.98 vs 44.18 +/- 15.57, respectively). However, the personal sacrifice burden was significantly higher in the MNCD-AD group (P = 0.043). The severity of AG of caregivers is correlated with caregiver burden (r = 0.735), cognitive decline (r = 0.575), and neuropsychiatric symptoms (R = 0.627) of the MNCD-AD patient. Conclusions: The results of the study highlighted that the disease type can influence the AG of caregivers in a qualitative rather than a quantitative manner. Future studies are recommended to consider effects of psychological or interpersonal factors on AG. In addition, psychiatric comorbidities among family caregivers of MNCD-AD patients should be examined
Bekleme Süreleri ve Hasta Memnuniyeti Arasındaki İlişki: Şehir Hastanesi Örneği
No full textAmaç: Bu çalışmanın amacı bir şehir hastanesinin farklı polikliniklerine başvuran hastaların kayıt kabul bekleme, muayene olmak için bekleme, tetkik çekimi için bekleme ve tetkik sonucu için bekleme süreleri ve sunulan hizmete yönelik memnuniyet algılarını değerlendirmektir. Çalışmanın bir diğer amacı bekleme süreleri ile hasta memnuniyeti arasındaki ilişkinin ortaya konulmasıdır. Yöntem: Kesitsel nitelikte olan bu çalışmanın evrenini, bir şehir hastanesinin 10 farklı polikliniğine (İç hastalıkları, göz hastalıkları, kulak, burun ve boğaz (KBB), genel cerrahi, kardiyoloji, göğüs hastalıkları, kadın ve doğum hastalıkları, nöroloji, üroloji ve deri ve zührevi hastalıkları) başvuran hastalar oluşturmaktadır (N=131.861). Seçkisiz örnekleme yöntemlerinden basit tesadüfü örnekleme yönteminin kullanıldığı bu araştırmaya 472 hasta katılım sağlamıştır. Araştırmada kullanılan ölçüm aracının yüksek düzeyde güvenilir ve geçerli olduğu hesaplanmıştır. Bulgular: Yapılan analiz sonucunda; hastaların yarısından fazlası MHRS sistemini kullanarak 8-15 gün arasında randevu aldıklarını bildirmiştir. Hastaların yarısı, hastaneden almış oldukları hizmete ilişkin genel bekleme süresini uzun veya çok uzun bulduğunu ve hastaların büyük bir kısmı ise (%92,2) şehir hastanesi ile karşılaştırdıklarında özel hastanede daha az süre beklediklerini ifade etmiştir. Hastaların şehir hastanesinde tetkik için bekleme sürelerinin ortalama 142,07 saat; tetkik sonucu bekleme sürelerinin ise 109,78 saat olduğu hesaplanmıştır. Yapılan çoklu korelasyon analizi sonucunda; memnuniyet algısı ile tetkik bekleme süresi ve tetkik sonuç bekleme süresi arasında istatistiksel olarak anlamlı negatif yönlü düşük düzeyde; poliklinikte hizmet alma amaçlı bekleme süresi ile tetkik sonuç bekleme süresi arasında ise istatistiksel olarak anlamlı negatif yönlü düşük düzeyde bir ilişki saptanmıştır. Sonuç: Şehir hastanesine başvuran hastaların genel memnuniyet algısı yüksek olmakla birlikte hizmet almaya ilişkin genel bekleme algıları uzun veya kabul edilebilir bir süredir. Ayrıca anayasal bir hak olan sağlık hizmetlerine ulaşma süresi, tetkik ve tedavi süresinin uzunluğu, hizmete yönelik memnuniyet algısını etkileyebilmektedir. Özgünlük: Bu araştırma, hem şehir hastaneleri bağlamında bekleme sürelerini araştıran hem de bekleme sürelerini kapsamlı (tetkit bekleme süresi, tetkit sonuç bekleme süresi gibi) ele alan ilk ve tek çalışmadır.Aim: The aim of this study is to evaluate the waiting times for registration, examination, test imaging, and test results, as well as the perception of satisfaction with the services provided, for patients visiting different outpatient clinics of a city hospital. Another aim of the study is to reveal the relationship between waiting times and patient satisfaction. Method: The universe of this cross-sectional study consists of patients who visited 10 different outpatient clinics (Internal Medicine, Eye Diseases, Ear, Nose and Throat (ENT), General Surgery, Cardiology, Chest Diseases, Obstetrics and Gynecology, Neurology, Urology, and Dermatology and Venereology) of a city hospital (N=131,861). In this study, which used the simple random sampling method from the non-probability sampling methods, 472 patients participated. It has been calculated that the measurement tool used in the study is highly reliable and valid. Results: As a result of the analysis, more than half of the patients reported that they had made appointments using the MHRS system within 8-15 days. Half of the patients found the overall waiting time for the services they received from the hospital to be long or very long, and a large portion of the patients (92.2%) stated that they waited less time in the private hospital compared to the city hospital. It was calculated that the average waiting time for tests in the city hospital was 142.07 hours, while the waiting time for test results was 109.78 hours. As a result of the multiple correlation analysis conducted, a statistically significant negative low-level relationship was found between the perception of satisfaction and the waiting time for tests and the waiting time for test results; and a statistically significant negative low-level relationship was found between the waiting time for outpatient services and the waiting time for test results. Conclusion: Although the overall satisfaction perception of patients applying to the city hospital is high, the general perception of waiting times for services is long or within an acceptable range. Additionally, the duration of access to healthcare services, which is a constitutional right, as well as the length of examination and treatment periods, can affect the perception of satisfaction with the service. Originality: This research is the first and only study that investigates waiting times in the context of city hospitals and comprehensively addresses waiting times (such as examination waiting time, examination result waiting time)
