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Are Dietary and Serum Advanced Glycation End Products (AGEs) Potential Contributors to Inflammation in Women with Polycystic Ovary Syndrome?
No full textBackground/Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by metabolic and hormonal imbalances in women of reproductive age. Various studies have emphasized that a diet high in advanced glycation end products (AGEs) and high serum AGE levels may be associated with reproductive and metabolic dysfunction in PCOS. Recently, the role played by dietary and serum AGE levels in the pathogenesis of PCOS was emphasized. Methods: In this study, we investigated the relationships between dietary AGE intake and serum AGE levels, some metabolic parameters, and anthropometric measurements in individuals with PCOS and a control group of women without PCOS. A total of 87 women with PCOS (n = 43) and without PCOS (n = 44) of a similar age and with a similar body mass index were included in this study. We analyzed dietary AGE intake, serum AGE (CML, sRAGE, and MGO) levels, and markers of inflammation (TNF-alpha and hs-CRP). Results: The daily dietary AGE intake in the PCOS group (13,191.05 +/- 3360.12 kU/day) was higher than that in the control group (11,740.28 +/- 2940.61 kU/day) (p = 0.035). The serum CML/sRAGE ratio was found to be higher in the PCOS group (413.94 +/- 1114.79) than in the control group (143.24 +/- 124.71) (p = 0.002). The cut-off points for dietary AGE intake, serum CML, and the CML/sRAGE ratio levels, which may be associated with the risk of PCOS development, were determined to be 11,359.06 kU/day, 417.50 ng/mL, and 140.91 ng/mL, respectively. Conclusions: Regular monitoring of serum AGE levels may reduce the health risks associated with PCOS. Moreover, to reduce dietary AGE intake in patients with PCOS, we recommend using steaming, boiling, poaching, or simmering with minimal water instead of dry-heat cooking methods
Investigation of Science Teachers’ Understanding of Flexible Inquiry
No full textEffective implementation of inquiry-based curriculums requires identifying and developing science teachers’ understanding of flexible inquiry. The current study aims to investigate science teachers’ understanding of flexible inquiry. To this end, the study employed the case study design, one of the qualitative research methods. The study group consists of eight science teachers conducting activities to foster flexible inquiry-based teaching. The data were collected from the teachers by using the explicitation interview method. The collected data were analyzed by using the descriptive analysis technique. According to the analysis results, teachers’ understandings of flexible inquiry were classified into three categories: those who possess a flexible inquiry understanding, those who are close to this understanding, and those who are distant from it. By presenting these understandings on a spectrum, the categorization aims to promote a more flexible and comprehensive perspective on the concept. The factors considered in forming these categories were evaluated, by the end of the study, as the key criteria of flexible inquiry understanding. As a result of the study, a descriptive definition of flexible inquiry understanding in the context of science education was developed. Furthermore, the study emphasizes that the effective implementation of inquiry based teaching programs requires identifying and supporting teachers’ understandings of flexible inquiry
Fiziği oyunla öğrenmek: Öğretmen adaylarının oyunlaştırma ve oyun tabanlı öğrenmeye ilişkin deneyim ve görüşleri
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Il Mediterraneo a Firenze. La Sala di Bona e di Preveza a Palazzo Pitti e Il Suo Restauro
No full textThay ve Alok’un Felsefi Bakış Açısı ile Zen Sanatında Dışavurumcu Kaligrafik Yaklaşımlar
No full textKaligrafi sanatçılarının bilinç altındaki durumları ve kendi iç dünyalarını zen sanat formlarından biri olan kaligrafi ile dışa vurma eğilimi vardır. Araştırmanın amacı, zen ustası Hsu Kwang-han ile Thich Nhat Hanh’nın felsefi bakış açılarını en iyi yansıtan kaligrafilerinin dışavurumcu tarafını ele almak, zen kaligrafisini ve dayandığı felsefeyi seçilmiş uygulamalar üzerinden incelemektir. Bu makalede nitel araştırma yöntemlerinden doküman incelemesi kullanılmış ve eser analizi yapılmıştır. Araştırmada her iki sanatçıdan üçer zen kaligrafisi ön yapı – arka yapı kategorisi ile değerlendirilmiş, sonuçta zen sanatçılarının eserlerini oluşturma aşamalarında kendilerinin ve izleyicilerinin doğru nefes ile bilinçli farkındalığı artırma hedefleri olduğu görülmüştür.Calligraphers tend to express their subconscious states and inner worlds through calligraphy, one of the Zen art forms. The purpose of this research is to address the expressive side of the calligraphy of Zen masters Hsu Kwang-han and Thich Nhat Hanh, which best reflects their philosophical perspectives, and to examine Zen calligraphy and its underlying philosophy through selected practices. In this article, document analysis, one of the qualitative research methods, was used and artifacts were analysed. The research evaluated three Zen calligraphies by both artists under the category of front structure - back structure. The results show that Zen artists aim to increase their own and their audience’s awareness through correct breathing during the creation phase of their work
Development of a Novel Judo-Specific Ippon Reactive Agility Test: A Reliability and Validity Study.
No full textClinical Characteristics and Genotype-phenotype Correlation in Turkish Patients with a Diagnosis of Resistance to Thyroid Hormone Beta
No full textObjective: Resistance to thyroid hormone beta (RTHβ) is a rare disorder characterized by a fairly heterogeneous clinical presentation due to varying degrees of tissue response to thyroid hormone. The present study aimed to evaluate the clinical and laboratory features and genotype-phenotype relationship of Turkish patients with RTHβ. Methods: Patients who underwent a THRβ gene analysis between September 2019 and September 2023 were retrospectively reviewed. Results: Fifty patients with the clinical features of RTHβ syndrome or a family history of an index case were included. A total of eight different heterozygous pathogenic/likely pathogenic missense variants, three of which were novel, were detected in THRB in 30 patients from 8 unrelated families. Although most patients with RTHβ were asymptomatic, seven patients exhibited various symptoms. Moreover, seven patients had received various treatments before diagnosis. Thyroid autoantibody was positive in 23% of all cases with a variant, and goitre was detected in 56% of children with a variant. While thyroid nodules were detected in seven adult patients, two adults had been diagnosed with papillary thyroid cancer. One child had attention-deficit disorder, learning disability, and type 1 diabetes mellitus. Of the 20 patients without a variant, TSHoma was detected in one. Conclusion: The present study provides an overview of clinical and genetic characteristics of patients with genetically confirmed RTHβ and expanded the THRB gene variant database with three novel variants. Although most patients with RTHβ are asymptomatic, molecular genetic analysis of the THRB gene and regular follow-up because of the apparent risk of concurrent autoimmune diseases or thyroid cancer is warranted
Effect of fracture level on optimal Kirschner wire configuration in pediatric supracondylar humerus fractures: A finite element analysis
No full textObjectives: This study aims to evaluate the biomechanical stability of three pin configurations for transverse supracondylar humerus fractures at various levels using finite element analysis (FEA). Materials and methods: Computed tomography data from a six-year-old child were used to generate a humerus bone model. Four different fracture levels (low, transolecranon, high, and ultrahigh) and three pin fixation techniques (one lateral and one medial cross-pin [1-1M], two lateral capitellar pins [1-1C], and three lateral capitellar pins [2-1C]) were designed for the study. Translational stiffness and rotational stiffness in all directions were analyzed in the mesh models. Convergence data and stiffness data were obtained in the FEA. Results: The translational and rotational stiffness values varied across fracture levels and pin configurations. Under valgus loading, the 1-1M configuration provided the highest stability in ultrahigh fractures (3289 N/mm), while the 2-1C configuration showed superior valgus and varus stability in low and transolecranon fractures. During extension and flexion loading, the 1-1M configuration yielded the highest stiffness values for transolecranon and high fractures, while the 2-1C configuration demonstrated increased stability in low and ultrahigh fractures. For rotational loading, 1-1M produced the highest inward and outward stiffness values in low-level fractures (9175 and 11035 N·mm/degree, respectively), whereas 2-1C displayed greater rotational stiffness in ultrahigh fractures. Conclusion: This preliminary study suggests that no single pin configuration is ideal for all fracture types, and the choice should be based on the specific fracture case