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3-Dimensional topographic enamel surface changes after different debonding techniques for aligner attachments: a micro-CT study
No full textIntroduction To evaluate topographic changes of enamel surface in 3-dimensional after different debonding methods of aligner attachments formed with 2 different composite resins. Methods Vertical rectangular attachments were created on 88 premolar teeth and divided into two composite resin groups (Group 1:flowable, Group 2:packable) (N = 44). These were then divided into two subgroups (N = 22) using different debonding methods. In Group A, the attachments were firstly removed using an attachment debonding plier and then with white fiberglass. Following, the tooth surfaces were polished with blue fiberglass. In Group B, the excess attachment composite was removed with a 12-blade carbide bur, followed by a 24-blade carbide bur, and tooth surfaces were polished with Renew stone. The remaining composite volume was measured using Geomagic Control X software. Enamel surface roughness and morphological change were compared between the groups. Results Residual composite resin volume did not show a statistically significant difference between composite resin groups (1-2 A). The enamel demineralization volume and area changes in Group 2 A were significantly higher than observed in 2B (p < 0.05). Roughness parameters Ra (T1-T0), Ra (T2-T0), Rq (T1-T0), and Sa (T1-T0) were significantly higher in Group 1B compared to Group 1 A (p < 0.05). Similarly, Ra (T1-T0), Sa (T1-T0), and Sq (T1-T0) parameters were significantly higher in Group 2B compared to Group 2 A (p < 0.05). Conclusions Fiberglass with a debonding plier produced a smoother enamel surface compared to carbide burs, but caused significantly more enamel demineralization, as seen in micro-CT evaluations after polishing
Affective modulation of emotional reactivity in euthymic patients with bipolar disorder
No full textAffective modulation of emotional reactivity in euthymic patients withbipolar disorderAffective modulation of emotional reactivity in euthymicpatients with bipolar disorderAim: Emotionaldysregulation is a hallmark feature of bipolar disorder (BD), contributing toimpairments in emotional processing. Understanding the mechanisms underlyingthe disruption of emotional reactivity (ER) in BD is crucial for developingeffective interventions. This study aims to compare subjective and objectiveemotional responses between euthymic BD patients and healthy controls, focusingon the affective modulation of the acoustic startle response (AMSR). Method:Euthymic BP(n=33) and healthy controls (n=35) were compared using both subjective andobjective measures. Subjective experiences, valence, and arousal scores wereassessed using the Self-Assessment Manikin. SR parameters were recorded from the orbicularis oculi muscle via electromyography. To assess the AMSR, pictures of varying emotional valences fromthe International Affective Picture System (IAPS) were used during acousticstimulation. Results: Patients andcontrols did not differ significantly in mean age, education years, chronicdiseases, marital status, and vascular risk factors. A significant valenceeffect was observed in the subjective picture evaluation; however, no significant group effector picture category-group interaction effect was detected. In the controls, picturecategories had a significant effect on both amplitude and area measurements, but didnot in euthymic BP. A linear pattern of startle amplitude across differentpicture categories was evident in the control group but not in patients. Nodifference was found between the two groups regarding latency, and valence didnot affect it. Mean Tamplitude Tarea, Tlatencyvalues across picture categories and groups are presented in Figure 1. Conclusion: Subjective responses did not significantly differbetween groups, objective AMSR was found to be blunted in euthymic BD patientscompared to controls, evidenced by reduced affective modulation in both SRamplitude and area. The study highlights the importance of utilizing both amplitude andarea measurements in assessing AMSR, with area measurements providingcomplementary information less susceptible to electrode placement variability.Large-scale studies with longitudinal designs are needed to explore theimpact of recurrent episodes and pharmacologicalinterventions on ER patterns. Keywords: Bipolar disorder, emotion, startle blink, EMG FIGURE 1 Figure 1: Mean Tamplitude (sub-figure (a)), Tarea(sub-figure (b)), Tlatency (sub-figure (c))values across picture categories and groups. *Significant differencebetween the mean T values of picture conditions with indicated valences P<0.05. </p
A preliminary phylogenetic analysis of Cerambycinae (Coleoptera, Cerambycidae) focusing on four Palaearctic genera: Cerambyx, Isotomus, Ropalopus and Neoplagionotus
No full textCerambycinae (Coleoptera, Cerambycidae) is a highly diverse subfamily of longhorned beetles, recognized for its significant economic and ecological importance. However, its phylogenetic relationships, even in the less diverse and much better understood fauna of the Northern Hemisphere, remain underexplored. Our study presents a preliminary phylogenetic analysis of the subfamily with a focus on primarily Palaearctic genera Isotomus Mulsant, 1862, Neoplagionotus Kasatkin, 2005, and Ropalopus Mulsant, 1839, as well as the type genus of Cerambycidae, Cerambyx Linnaeus, 1758. Maximum likelihood and Bayesian Inference analyses were conducted utilising two mitochondrial markers, COI and 16S rRNA, and two divergent domains (D1 and D2) of a nuclear marker, 28S rRNA, for 129 termini, 35 of them first time presented in this study. According to our results, Cerambyx was found to be paraphyletic due to the inclusion of Pseudaeolesthes. Ropalopus clustered with Callidium, Oupyrrhidium, and Semanotus in a distinct group from Phymatodes and Pyrrhidium that supports polyphyly of Callidini. In the tribe Clytini, Neoplagionotus was sister to Echinocerus, and they were separated from Plagionotus. The type species of Isotomus, I. speciosus, was placed sister to Demonax
Leaving the Ductus Open During BTT Shunt: Risk of Ductus-Associated Pulmonary Coarctation?
No full textEffect of dominant stricture and disease duration on prognosis in primary sclerosing cholangitis
No full textSome novel 5-benzylidenethiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives in the battle against cancer: Design, synthesis and their biological activities
No full textConsidering the significant biological potential and the privileged status of the 1,2,4-triazole-5-thione scaffold as one of the essential building blocks in medicinal chemistry, a novel series of 30 new hybrid compounds of 1,2,4triazole and 5-benzylidenethiazolidinone ring systems, named 5-benzilidene-thiazolo[3,2-b][1,2,4]triazole-6 (5H)-one, were designed and synthesized in an attempt to obtain antiproliferative agents and EGFR inhibitors. Synthesized thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones were investigated for their potential cytotoxic properties by cell viability, cell cycle, and cell death analyses. Compounds that exhibited more selective anti-growth activity in A549 cells were further scrutinized, revealing an accumulation in the G1 phase. Notably, compound 6e demonstrated outstanding results and was found to induce apoptosis. Molecular docking studies indicated that the designed compounds could act as EGFR inhibitors. Indeed, compounds 6i and 6j inhibited cell growth prevented EGFR-specific phosphorylation, and thus downregulated EGFR signaling, and inhibited EGFR enzyme activity with IC50 values of 2.46 mu M and 4.72 mu M, respectively. Additionally, druglikeness and some pharmaceutical properties of the synthesized compounds were predicted. This study underscores the promising therapeutic potential of the novel thiazolo[3,2-b]-1,2,4-triazole derivatives as EGFR inhibitors
Autologous adipose-derived tissue stromal vascular fraction and intralesional epidermal growth factor combined application in patients with diabetic foot
No full textObjective: The aim of this study was to evaluate the effect on wound healing of intralesional epidermal growth factor (iEGF) (Heberprot-p; Hasbiotech, Cuba) and autologous adipose-derived tissue stromal vascular fraction (AD-tSVF) applied in the closure of tissue defects. Method: The patients included in the study were separated into three approximately equal groups: Group 1 with iEGF+AD-tSVF applied; Group 2 with iEGF only applied; and Group 3 with conventional wound care products applied. Granulation tissue was taken from the wound bed before the application of iEGF and AD-tSVF and at intervals thereafter for flow cytometry analysis. Results: Group 1 included 11 patients; Group 2 included 10 patients; and Group 3 included 10 patients. The time to re-epithelialisation was determined as 187.60 +/- 68.78 days in Group 3 patients compared with Group 1 (72.27 +/- 10.33 days) and Group 2 (70.50 +/- 18.02 days) (p<0.001). Following the application of iEGF to the wound bed, an increase was observed in M2 macrophage (CD209+), and M1 macrophage (CD38+) levels. The (CD34+) stem cells obtained from the granulation tissue after the application of AD-tSVF were determined to still be statistically significantly increased in the wound bed on the 21st day. Conclusion: The results of this study demonstrated that the application of iEGF and iEGF+AD-tSVF significantly shortened the wound healing period compared with conventional methods. AD-tSVF stands as an effective option, especially in the patient group with halted or delayed wound healing despite the application of iEGF. Moreover, the significant increase (p<0.001) in the level of M2 macrophages (CD209+), M1 macrophages (CD38+) and stem cells (CD34+) provided by this treatment modality showed that it contributed to wound healing at the cellular level
Sensitivity Analysis of Material Parameters on the Microscale Stress Distribution in Glass Fiber-Reinforced Composites in Transverse Loading
No full textEffect of material parameters on microscale stress distribution in glass fiber-reinforced composite were evaluated quantitatively using statistical methods. These effects have already been studied through the development of numerous complicated numerical models as well as basic analytical models, but their numerical relations have not been addressed. Monte Carlo simulation and finite element analysis (FEA) were performed with various fiber volume ratios and material parameters. Stress concentration results gathered from the FEA were investigated via parametric correlation technique to observe the relation between the parameters and the stress concentrations. A parameter called over-stressed volume percentage (OVP) was introduced to capture the influence level of material parameters causing too high stress concentrations and to give indication about the failure initiation. The results reveal the sensitivity of the parameters on the stress concentrations and the comparison of their effects with each other, numerically. Fiber volume ratio has shown to have much more effect on the maximum stress concentrations and OVP compared to the other material parameters. Variation in the Poisson's ratio does not cause a significant change on the stress concentrations
Guideline for the Use of Natriuretic Peptides in the Early Diagnosis and Management of Heart Failure in Primary Care<i> (Joint</i><i> Consensus</i><i> Report</i> <i>by the Eurasian Society of Heart Failure and the Turkish Association of Family Medicine)</i>
No full textHeart failure (HF) is a complex clinical condition associated with significant morbidity and mortality. Early diagnosis and effective management at the primary care level are essential for improving patient outcomes and reducing the burden on the healthcare systems. The Eurasian Society of HF and the Turkish Association of Family Medicine developed a guideline that underscores the critical role of natriuretic peptides (NPs) in the early detection, diagnosis, and management of HF. NPs, particularly the N-terminal pro-B-type NP, are a reliable biomarker for identifying HF, guiding treatment decisions, and monitoring disease progression. This guideline emphasizes the importance of measuring the levels of these peptides in primary care so as to detect individuals at risk, confirm the diagnosis of HF in symptomatic patients, and evaluate the treatment response. The recommended thresholds for NP levels account for variations arising from factors such as age, gender, and the presence of other health conditions. B-type natriuretic peptides (BNP) levels >= 35 pg/ml or N-terminus-proBNP levels >= 125 pg/ml are used to confirm the likelihood of HF in symptomatic patients, enabling timely diagnosis and appropriate intervention. Incorporating NP testing into routine clinical practice enables timely referrals and ensures appropriate management at all stages of HF. Beyond diagnosis, the measurement of NPs provides valuable information about treatment effectiveness and prognosis, allowing clinicians to individualize the treatment. By integrating NP testing into primary care, healthcare providers can facilitate early detection, optimize treatment strategies, and improve the quality of life for patients with or at risk of HF. Thus, this guideline highlights the essential role of primary care physicians in addressing the growing challenges of HF through the effective and evidence-based use of NPs
