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Lectotypification of the name Kundmannia syriaca (Apiaceae)
No full textKundmannia syriaca was recently transferred to the genus During this research it became clear that the name K. syriaca to be typified. One of the two isotypes preserved in the herbarium Geneva was designated as the lectotype of K. syriaca
Parmak İzlerinin Moleküler Kimliklendirilmesi: Olay Yerinin Yeniden Yapılandırılmasında Parmak İzlerinin Kimyssal İmza Korelasyonunun Analizi
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The usability and effectiveness of the Mobithera application on musculoskeletal pain and physical function in adult caregivers of oncology patients: a single-group pilot study
No full textThis pilot study evaluated the effectiveness and usability of the Mobithera application, a mobile health intervention designed to reduce musculoskeletal pain and improve physical function in adult caregivers of oncology patients. Thirty-five caregivers with self-reported neck or lower back pain participated in this study. The intervention involved 10 sessions over two weeks, during which participants performed therapeutic exercises using the Mobithera. Pain levels, lower extremity reaction time, body awareness, and balance were assessed before and after the intervention using to the Visual Analog Scale (VAS), Rapid Foot-Tap Test, Fremantle Awareness Scales, and Tinetti Gait and Balance Test. Usability of the application was evaluated using the System Usability Scale (SUS). The Mobithera significantly reduced both neck and lower back pain among participants. Improvements were also observed in lower extremity reaction time, body awareness, and balance. The findings suggest that the Mobithera is effective in enhancing the physical health and well-being of caregivers. The Mobithera demonstrates significant potential as a supportive tool for caregivers, reducing pain and improving physical function. Further research with larger sample sizes and longer follow-up periods is recommended to confirm these findings and explore the long-term benefits of such interventions in the caregiver population
Prospective teachers’ views on professional teaching knowledge courses in the context of teaching practice
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Synergistic antioxidant performance of lignin extracted with deep eutectic solvent from olive mill solid waste in polyvinyl alcohol films and nanofibers
No full textLignin is known to exhibit synergistic antioxidant effects when used together with small molecule antioxidants. However, whether similar effects occur in polymer blends containing lignin as the only antioxidant component remains largely unexplored. This study investigates the synergistic antioxidant effects of lignin derived from olive mill solid waste (OL) when incorporated as the sole active component in polyvinyl alcohol (PVA) polymer blends. PVA films and electrospun fibers containing 0-11 wt% OL showed antioxidant activity exceeding rule-of-mixtures predictions. The maximum synergy occurred at 4 wt% OL, with enhancements of 480% for films and 971% for fibers, compared to 33% for sodium lignosulfonate. Spectroscopic and thermal analyses revealed that this synergy stems from morphology-dependent intermolecular interactions. These findings represent one of the strongest synergistic antioxidant effects reported for a lignin/polymer system, presenting a sustainable pathway to convert agricultural waste into high-performance materials for active packaging and other advanced applications
A dual- enzyme targeted approach: Flurbiprofen-linked 1,2,4-triazole-3-- thione schiff bases against acetylcholinesterase and α-glucosidase
No full textIn this investigation, 1,2,4-triazole-3-thione Schiff bases containing a flurbiprofen moiety were designed and synthesized. The structures of these compounds were confirmed with moderate to good yields using NMR and IR spectroscopic analyses. To demonstrate their biological potential, the compounds were evaluated for their in vitro inhibitory activities against acetylcholinesterase (AChE) and alpha-glucosidase. Most of the synthesized products demonstrated notable inhibitory efficacy against the enzymes AChE and alpha-glucosidase when compared to the standard medications tacrine (IC50 = 265.78 nM for AChE) and acarbose (IC50 = 78.51 nM for alpha-glucosidase). Among the substances that were examined, 2t ((E)-5-(1-(2-fluoro-[1,1 '-biphenyl]-4-yl) ethyl)-4-((4hydroxybenzylidene) amino)-2,4-dihydro-3H-1,2,4-triazole-3-thione) demonstrated inhibitory action with IC50 values of 78.95 nM for AChE, and 2r ((E)-5-(1-(2-fluoro-[1,1 '-biphenyl]-4-yl) ethyl)-4-((2-hydroxybenzylidene) amino)-2,4-dihydro-3H-1,2,4-triazole-3-thione) demonstrated inhibitory activity with IC50 values of 80.08 nM for AChE, and 2j ((E)-5-(1-(2-fluoro-[1,1 '-biphenyl]-4-yl) ethyl)-4-((4-fluorobenzylidene) amino)-2,4-dihydro3H-1,2,4-triazole-3-thione) demonstrated inhibitory activity against alpha-glucosidase with an IC50 values of 9. 05 nM. The docking and kinetic tests confirmed the predicted drug-like properties and experimental outcomes from in vitro experiments. The discovery of such potent dual inhibitors is highly significant. These findings open new avenues for designing drugs that could simultaneously target mechanisms involved in complex diseases like Alzheimer's, where AChE inhibition is a key therapeutic strategy, and diabetes, managed by alpha-glucosidase inhibitors. Our research offers a promising foundation for the development of potentially highly effective therapeutic agents
Disentangling subspecies delimitation in<i> Heldreichia</i><i> bupleurifolia</i> Boiss. (Brassicaceae) through genomic and quantitative morphological approaches
No full textHeldreichia bupleurifolia Boiss., the only species in its genus, is distributed across the Taurus and Anatolian Diagonal Mountains in T & uuml;rkiye and presents considerable taxonomic challenges. The species is currently divided into five subspecies and one variety and has long posed challenges for infraspecific classification due to overlapping morphological traits and unresolved phylogenetic relationships. To address these issues and clarify the boundaries of the described subspecies and their evolutionary history, this study integrates comprehensive morphometric analyses of 502 individuals from 36 populations, as well as SNP- and locus-based genomic analyses from RAD-seq data of 136 individuals from 20 populations. While morphometric assessments showed significant differentiation in foliar and fruit traits, especially between western and eastern populations, genomic analyses identified distinct genetic clusters corresponding to geographic regions. High levels of genetic admixture and morphological plasticity were seen in the Central Taurus populations, indicating either historical hybridization or the preservation of ancestral polymorphisms. In accordance with morphological and admixture analyses, coalescent-based subspecies delimitation supported a three-subspecies model, resulting in revised taxonomic classifications that included new combinations. To further contextualize these results within an evolutionary perspective, we adopted the speciation continuum framework, interpreting morphological, genetic, and reproductive differentiation as components of a continuous process of divergence. These results emphasize the drawbacks of using morphology alone for taxonomy and the value of integrative methods for determining subspecies boundaries in areas with complex topography
The Late Neolithic chipped stone industry from the new excavations at Domuztepe: preliminary observations
No full textThis study evaluates the initial findings concerning the chipped stone industry unearthed during the post-2021 excavations at Domuztepe Hoy & uuml;k, located in the T & uuml;rkiye's Eastern Mediterranean region. The chipped stone artifacts recovered from various architectural units have been analyzed through a cha & icirc;ne operatoire approach. The research specifically addresses first assessment of raw material preferences, production strategies, tool types, and initial spatial observations. These assessments provide an opportunity to reconsider the traditions of chipped stone production and use at Domuztepe during the Neolithic period and contribute to the existing knowledge on this subject. This study constitutes a preliminary assessment intended to establish a basis for future research aiming to define Domuztepe's position within the T & uuml;rkiye's Eastern Mediterranean through its chipped stone assemblage and to enable interregional comparisons. For this reason, the scope of the present study has been limited to the chipped stone assemblage from Domuztepe