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Comprehensive <i>in vitro</i> and <i>in vivo</i> assessment of spongin/hydroxyapatite biohybrid scaffolds for bone regeneration
No full textThe selection of an appropriate scaffold is vital for successful bone tissue engineering. Biohybrid scaffolds, combining the mechanical tunability of synthetic polymers with the biocompatibility of natural materials, have gained significant attention. In this study, biohybrid scaffolds were developed using spongin isolated from the marine sponge Sarcotragus foetidus (Sf), mimicking natural bone architecture. These scaffolds were functionalized with hydroxyapatite (HAp) and boron-doped HAp (B-HAp) to enhance mechanical and osteoconductive properties. Micro-computed tomography (mu CT) revealed interconnected porosity above 70 % in all groups, facilitating nutrient exchange and cell migration. Elemental analysis confirmed the presence of carbon, oxygen, calcium, and phosphorus, essential for bone regeneration. Mechanical testing showed increased Young's modulus values, reaching similar to 20 kPa for Sf/HAp and similar to 22 kPa for Sf/B-HAp, due to the reinforcing coatings. In vitro assays over 21 days showed that the Sf/B-HAp scaffold exhibited the highest mineralization, alkaline phosphatase (ALP) activity, collagen synthesis, and extracellular matrix (ECM) formation, indicating enhanced osteogenic capacity. Additionally, antibacterial tests showed superior activity for the Sf/B-HAp group. In vivo studies conducted using a rat calvarial bone defect model over a 20-week period demonstrated significant bone regeneration across all groups, with the Sf/B-HAp scaffold exhibiting the most pronounced effect. Overall, Sf-based scaffolds supported cell adhesion, proliferation, and differentiation, with the Sf/B-HAp variant offering superior mechanical, osteoconductive, osteoinductive, and antibacterial properties-making it a promising candidate for advanced bone tissue engineering
Yeşil Dikkatten Kaçar Mı? Biyoloji Öğretmen Adaylarının Ders Kitaplarındaki Bitkileri Fark Edebilme Yetenekleri
No full textUse and Design of Active Bracing Systems in the Protection of Structures under Seismic Excitation
No full textFluorometric and colorimetric selective detection and differentiation of amines and phenols: Aromatic nucleophilic substitution of Br-BODIPYs with N- and O-nucleophiles
No full textIn this study, a new BODIPY-based chemosensor (MetBDP) was developed for the selective detection and differentiation of amines and phenols. The sensor's photophysical properties were explored through the substitution of halogens at the alpha-positions of BODIPY by these analytes. While amines interact with MetBDP without the need for K2CO3, phenols require the presence of K2CO3 to induce a photophysical response. This distinct behavior allows for the clear differentiation between amines and phenols. This is the first fluorescent chemosensor capable of discriminating phenols from amines. MetBDP demonstrated high sensitivity toward amines and phenols. The test made on pentylamine showed that amine can be quantified at such low detection limits as 19 nM
Machine learning-based prediction of inborn errors of immunity in patients with low IgE levels.
No full textFrom social identity to team performance: Linking transactive memory systems and teamwork
No full textCultivating a shared team identity fosters individuals' sense of belonging and strengthens their connection to the team. Previous studies have demonstrated that having a shared team identity and strongly identified individuals within the group are associated with various positive outcomes. Among these positive outcomes, increasing evidence from the organizational field suggests that a shared identity may serve as a foundational mechanism in the emergence of transactive memory systems (TMS). TMS refers to shared cognitive structures that enable team members to encode, store, and retrieve information collectively. The main objective of this study was to examine the relationship between team identification and transactive memory systems, as well as to investigate their effects on teamwork behaviors and overall performance of sport teams in unique tournament settings. A 3-wave longitudinal research design was employed to examine these associations, involving 167 athletes across 15 teams. Structural equation modelling indicated a significant relationship between team identification and transactive memory systems in the pre-tournament phase. Furthermore, pre-tournament transactive memory systems predicted teamwork behaviors during the tournament, positively influencing overall team performance. Our exploratory findings underscore how the short duration and high-pressure nature of the tournament differentially shaped teams' adaptive responses. Specifically, only mid-ranking teams showed significant improvements in adjustment behaviours from pre-tournament to mid-tournament, whereas both lower-and higherranking teams exhibited non-significant change. Based on these findings, to optimize a team's performance in a time-limited context such as tournaments, sport psychologists and coaches are encouraged to cultivate a shared team identity through social identity focused workshops or identity leadership interventions, and social activities with a heightened sense of psychological safety (e.g. open discussions for role clarity), which can develop transactive memory systems and, in turn, enhance teamwork behaviors and overall team performance. Consequently, the present study aims to adopt a collective-cognitive approach to the link between social identity and team performance in a sporting context, and to shed light on how team functioning unfolds under time-constrained conditions
İç Mekan Tasarımlarının 6769 Sayılı Sınai Mülkiyet Kanunu Kapsamında “Tasarım” Olarak Korunmasına Yönelik Paydaş Görüşleri
No full textFikri bir çabanın ürünü olan iç mekan tasarımlarının, artan rekabet ortamında hukuki olarak korunması bir gerekliliktir. Bu çalışmada, özünde bir tasarım faaliyeti ürünü olan iç mekan tasarımlarının 6769 sayılı Sınai Mülkiyet Kanunu (SMK) kapsamında “tasarım” olarak korunması incelenmektedir. Araştırmanın amacı, iç mekan tasarımlarının SMK kapsamında nasıl ve ne şekilde korunduğunu; mevcut sistemde teori ve uygulamada karşılaşılan sorunlar ile bu sorunların kaynaklarını ortaya koymaktır. Bu kapsamda, tescil başvuru süreçlerinde görev alan patent ve marka vekilleri, değerlendirme süreçlerinde yer alan bilirkişiler, Fikri ve Sınai Haklar Hukuk Mahkemesi’nde görev yapan veya yapmış hakimler ile Türk Patent ve Marka Kurumu (TÜRKPATENT) Tasarım Dairesi ve Telif Hakları Genel Müdürlüğü uzmanlarıyla görüşmeler gerçekleştirilmiştir. Nitel araştırma yöntemiyle yürütülen çalışmada, yarı yapılandırılmış sorularla 32 katılımcıyla görüşülmüş; elde edilen veriler içerik analizi yöntemiyle incelenmiştir. Bulgular, mevcut sistemde iç mekan tasarımlarına yönelik hukuki bir koruma olduğunu, ancak söz konusu koruma mekanizmasının yetersiz kalabildiği noktaların bulunduğu anlaşılmıştır. Bu yetersizliklerin iç mekan tasarımlarının doğası ve yapısından kaynaklandığı tespit edilmiştir. Bir diğer dikkat çekici bulgu ise iç mekan tasarımı kavramının ne olduğuna ilişkin kavramsallaştırma sorunları olmuştur. Sonuç olarak bulgular doğrultusunda konuya ilişkin öneriler verilmiştir. The legal protection of interior designs, which are the product of intellectual effort, is a necessity in an increasingly competitive environment. This study examines the protection of interior designs, which are essentially the product of a design activity, as “designs” under Industrial Property Code No. 6769 (IPC). The aim of this research is to determine how and in what manner interior designs are protected under the IPC, to assess the adequacy of the current system, and to identify the issues encountered in theory and practice, as well as their sources. Within this scope, interviews were conducted with patent and trademark attorneys involved in registration application processes, experts participating in legal procedures, judges serving or who have served at the Intellectual and Industrial Rights Court, and experts from Turkish Patent and Trademark Office (TÜRKPATENT) Design Department and the Copyright General Directorate. The study, which was conducted using qualitative research methods, involved interviews with 32 participants using semi-structured questions, and the data obtained were analyzed using content analysis methods. The findings show that there is a legal protection mechanism for interior designs within the current system; however, it has been understood that this mechanism may remain insufficient in certain aspects. These inadequacies have been identified as stemming from the nature and structure of interior designs. Another significant finding is the lack of knowledge regarding the concept of “interior design.” In conclusion, recommendations on the subject have been provided in line with the findings.</p
