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A proposal for the design of a knowledge-building system to develop computational thinking skills in middle school students: MobiForum
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Universal Memory, Construing, Thinking, and Intelligence Pathways: The Inertial Reference System for Direct and Inverse Universal Thinking and Learning Framework Mechanisms as Self Embedded Processes
No full textThis study addresses finding the most minor ingredients of thinking, understanding, and learning processes and acting according to thinking, understanding, and learning triplet by providing their functional relations among the builders through topological unification operators as independent from the species. That independence brings the universal ingredients of intelligence, construing, and memory structures covering the universal learning, understanding, and thinking processes, spontaneously. The thinking, understanding, and learning triplet constructs universal mechanism as a directly frame scheme, while the learning, understanding, and thinking triplet constructs universal mechanism as an inversely frame scheme. Those are derived how those are generated spontaneous communication, language, and control processes from the perturbational transitions with displacements among states on pathways. The basics are given for universal language of intelligence and the applicability of above said processes
Targeting Strategy: Bacteriophage Receptor-Binding ProteinDecorated Nanocarriers for Enhanced S. aureus Treatment
No full textTARGETING STRATEGY: BACTERIOPHAGERECEPTOR-BINDING PROTEIN-DECORATED NANOCARRIERS FOR ENHANCED S. aureusTREATMENTSenanur DOKUZ1, IremCOKSU2, Semra TASDURMAZLI1, Berna ERDOGDU1, SerapACAR2, Tulin OZBEK1*1Yildiz Technical University, Faculty of Artsand Sciences, Department of Molecular Biology and Genetics, Istanbul, Turkey2Yildiz Technical University, Faculty ofChemical and Metallurgical, Department of Bioengineering, Istanbul, TurkeyKeywords: Receptor binding protein, targetednanoparticle, S. aureus infectionBackground and aims: Combining the advantages of nanocarrierswith the precision of bacteriophage-based solutions in the fight againstbacterial infections is approaches that will strengthen our hand in treatment. Inthis study, after determining the potential of phage K receptor binding protein(recombinantly produced rGp144) as a targeting agent, rifampicin-loaded PLGAnanoparticle (RIF144-NP) decorated with it was synthesized, characterized andevaluated for its in vitro antimicrobial activity. Methods: Specific targeting of rGp144 wasdemonstrated by confocal microscopy and ELISA. Nanoparticles were synthesizedby nanoprecipitation method and coated with rGp144. The particle size, zetapotential, drug loading value and drug release profile of nanoparticles were examined.Their antibacterial activity is determined by broth microdilution, time-dependent-growth-curveand agar-well diffusion methods against resistant and sensitive S. aureusstrains.Results: The binding of rGp144 to both S.aureus and methicillin-resistant S. aureus (MRSA) was demonstratedby confocal microscopy, with a capture efficiency of over 87% was determined byELISA. The drug loading capacity of RIF144-NP with a size of 300 nm and a zetapotential of -11 mV was obtained as 26.64% and the nanosystem continued torelease for 4 days. The nanoparticles reduced the MIC twofold in all strains(for MRSA;0.0012µg/mL), moreover in agar-well diffusion; for 0.015µg/mL,RIF144-NP against MRSA had a 9 mm zone, but not at RIF-NP and free antibiotic.Conclusions: RIF144-NP proved to be much moreeffective in bacterial elimination in all strains studied compared to freeantibiotic and non-targeted nanoparticle. These findings underline the superiorantibacterial potential of RIF144-NP in the treatment of S. aureus.</p
Enhancing Irrigation Scheduling Accuracy Through Machine Learning and Deep Learning: A Case Study on Evapotranspiration and Soil Water Content Modeling
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