Open Access Publications (Univ. de Genève)
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Monoclonal antibodies RB139 and RB142 recognize citrullinated LL37 by immunofluorescence in histological sections in Systemic lupus erythematosus (SLE) and Rheumatoid arthritis (RA)
Get PDFLL37 is a natural antibiotic, but is also a molecule with pleiotropic functions as well as an immune-modulator. LL37 is produced by epithelial cells and is present in neutrophils’ granules. LL37 alone, or in complex with DNA, can activate inflammatory pathways in psoriasis, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this work, we describe the capacity of two recombinant monoclonal antibodies, RB139 and RB142, previously shown to specifically recognize LL37 in its citrullinated form (cit-LL37) by ELISA, to detect LL37 by immunofluorescence in human inflamed tissues derived from SLE and RA patients. Such antibodies represent previously unavailable tools to detect the presence, the citrullinated state and the exact localization of cit-LL37 in human tissues in health and disease
RB620 and RB621 antibodies recognize a peptide of the SARS-CoV-2 E protein by ELISA
Get PDFThe recombinant antibodies RB620 and RB621 detect by ELISA a synthetic peptide from the SARS-CoV-2 envelope E protein
A Broken Screw in the Soviet System. The Life and Fate of Leonid Nikolaev
Get PDFThe tectonic change of 1917 not only disrupted the country but also placed, for a brief moment, a “little man” at the centre of “big story.” Nikolaev was a typical representative of ordinary people being pushed into a corner by circumstances and deceived in their expectations by a pseudo-socialist state. The high expectations of ordinary people, who were involved by the Bolsheviks in their politics, naturally crashed into the harsh realities of the construction of socialism.Brought to political life from social non-existence, this ordinary man soon became unnecessary to the new political regime’s needs and was subject to manipulation and mobilization by the party. This is how he ended up being merged with the human mass, which was faceless to the party nomenclature. However, this ordinary man was opposed to the latter and thus became the cause of large-scale social cataclysms. He got a weapon and killed Kirov; the personification of the political power against which Nikolaev’s act was directed.In the early Soviet period, many representatives of this social stratum raised their voices in protest, even if not in a terrorist form. Many of them were physically eliminated, the rest were brought to submission. This was a demonstration of the toughness of the Bolshevik regime, which transformed into the regime of Stalin’s personal power in the 1930s, involving terrorist forms of governing.Le changement tectonique de 1917 a non seulement bouleversé le pays mais il a aussi placé, pour un court instant, un « petit homme » au centre de la « grande histoire ». Nikolaev était un représentant typique des gens ordinaires impliqués par les bolcheviks dans leur politique, qui furent acculés dans un coin par les circonstances et trompés dans leurs attentes par un État pseudo-socialiste.Passé de l’inexistence sociale à la vie politique, cet homme ordinaire devint vite inutile aux yeux du nouveau régime politique et fit l’objet de manipulations et de mobilisations du parti. C’est ainsi qu’il finit par se fondre dans la masse, qui, pour la nomenclature du parti, n’avait pas de visage. Or cet homme ordinaire s’opposa à cette dernière et devint la cause de cataclysmes sociaux à grande échelle. Nikolaev se procura une arme et assassina Kirov, qui symbolisait le pouvoir politique, contre lequel l’acte de Nikolaev était dirigé.Au début de la période soviétique, de nombreux représentants de cette couche sociale élevèrent leur voix pour protester, même si ce n’était pas sous une forme violente. Nombre d’entre eux furent éliminés physiquement. La dureté du régime bolchevique qui, durant les années 1930, se transforma en un pouvoir personnel de Staline, impliquait en effet des formes terroristes de gouvernement
Introdução: Leituras do país dos "descobrimentos" no final do século XX.
Get PDFLe premier dossier thématique de la revue Língua-lugar, coordonné par Pedro Cerdeira, réunit des articles de Pedro Martins, Marta Araújo, Nazaré Torrão et Octavio Páez Granados, et Catarina Duff Burnay.
Le dossier revisite l’Expo’98 et des produits culturels en rapport avec cette même exposition, notamment l’opéra White Raven et le feuilleton Terra Mãe. Interrogeant la forme par laquelle l’exposition s’est appropriée la période historique de l’expansion maritime, nous souhaitons, au sein de ce dossier, apporter une contribution à la compréhension de l’impact des initiatives de commémoration et de la construction de l’identité nationale dans le Portugal contemporain. Pour ce faire, nous avons eu recours à différentes disciplines, à savoir : l’histoire, les sciences de la communication, les sciences de l’éducation et les études littéraires.O primeiro dossiê temático da revista Língua-lugar, coordenado por Pedro Cerdeira, reúne artigos da autoria de Pedro Martins, Marta Araújo, Nazaré Torrão e Octavio Páez Granados, e Catarina Duff Burnay.
O dossiê revisita a Expo’98 e produtos culturais a ela associados, designadamente a ópera Corvo Branco e a telenovela Terra Mãe. Interrogando a forma como a exposição se apropriou do período histórico da expansão marítima, o dossiê pretende ser um contributo para o entendimento do impacto de iniciativas comemorativas e da construção da identidade nacional no Portugal contemporâneo. Para tal, convoca o contributo de diferentes disciplinas, nomeadamente a história, as ciências da comunicação, as ciências da educação e os estudos literários
AI842, AI843, AI844 and AI177 antibodies do not recognize a FLAG-tagged protein expressed in D. discoideum by western blot
Get PDFThe recombinant antibodies AI842, AI843, AI844 and AI177 do not detect by western blot an N-terminal FLAG-tagged RavZ protein expressed in Dictyostelium discoideum
The AJ519 antibody detects the human TAC/ILR2A protein by western blot
Get PDFThe AJ519 antibody detects the human TAC protein by western blot
The AL626 antibody recognizes an ALFA-tagged recombinant protein by immunofluorescence
Get PDFThe AL626 antibody against the ALFA tag recognizes an ALFA-tagged human TAC protein by immunofluorescence in paraformaldehyde-fixed HeLa cells
The AI196 antibody recognizes a SPOT-tagged recombinant protein by immunofluorescence
Get PDFThe AI196 antibody against the SPOT tag recognizes a SPOT-tagged human TAC protein by immunofluorescence in paraformaldehyde-fixed HeLa cells
RB014, RB015 and RB016 antibodies recognize a peptide of the D. discoideum Phg1A protein by western blot
Get PDFRecombinant antibodies RB014, RB015 and RB016 detect by western blot a peptide of the Dictyostelium discoideum Phg1a protein fused to a GST protein
The RB030 antibody recognizes a peptide of the D. discoideum TspB protein by western blot
Get PDFThe recombinant antibody RB030 detects by western blot a peptide of the Dictyostelium discoideum TspB protein fused to a GST protein; RB029 does not