Open Access Publications (Univ. de Genève)
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Awakening the thymus to cure SARS-CoV-2 infection: a matter of genes
No full textEstablishing an appropriate immune response is essential to recover from viral diseases such as COVID-19.The thymus, an organ of the immune system, plays a vital role in producing new T-lymphocytes that help eliminate the virus that causes COVID-19. We recently discovered that a genetic trait determines the effectiveness of thymic activity in fighting this virus, and thus the clinical outcome
Reversible Anticoagulants: Inspired by Nature, Designed for Safety
No full textUpon biting, blood sucking insects inject an anti-coagulant to enjoy their meal. These anti-coagulants have inspired approved drug. Combining this concept with supramolecular chemistry, we developed a novel bi-functional drug. It shows strong in vivo effects and can be reversed with an \u27antidote,\u27 a sought-after trait in anti-coagulant treatments. This property extends to other therapies like immunotherapies, broadening its potential impact on diverse medical applications
Exceptional preservation of three-dimensional dunes on an ancient deep-marine seafloor: implications for sedimentary processes and depositional environments
Get PDFDepositional and erosional bedforms can be used to reconstruct sedimentary processes and aid palaeoenvironmental interpretations. Using exhumed deep-marine strata in the Eocene Aínsa Basin, Spain, we document a 3-dimensional package of dunes, a rarely identified bedform in deep-marine environments. Our analysis shows that the dunes have curvilinear crests in planform, with smaller superimposed oblique dunes and ripples across the stoss sides. Beds containing these dunes have two main internal divisions: a lower inversely-graded (fine-to-coarse sandstone) and predominantly structureless division, and an upper coarse-grained sandstone division with well-developed cross-stratification, which is scoured and mantled with mudclasts and coarse-grains on the stoss-side. The rugose remnant relief of the bedforms controls the location of subsequent bedforms. Following recently reported direct measurements of natural turbidity currents, we interpret the basal division as recording deposition from the dense basal head of a high-velocity turbidity current, followed by the development of dunes beneath the more sustained but relatively high-velocity and unsteady flow body that reworked the initial sandy deposit into downstream migrating dunes and scours. These dune-forming beds have been identified in different deep-water environments in the Aínsa Basin stratigraphy, including channel overbank and channel mouth settings and scour-fills. These locations suggest that the dunes were intimately tied to high-velocity flows that bypassed through channel axes before expanding and depositing in less confined channel overbank or channel mouth settings. Preservation of these dunes in the Aínsa Basin was likely enhanced by tectonically-forced lateral migration of channels, which prevented cannibalisation of bypass-dominated zones, in combination with high aggradation rates due to confinement. Where identified these dune-like bedforms are considered diagnostic of substantial sediment bypass downslope to deep-water basins.
This article has a related Corrigendu
AI516 and AI523 antibodies recognize the O-antigen of K. pneumoniae KpGE strain by western blot
No full textThe recombinant antibodies AI516 and AI523 detect by western blot the O-antigen of Klebsiella pneumoniae KpGE strain
New, smaller-than-ever devices to help us understand how our brain works from the inside
No full textWe developed a new neural probe which can be inserted into the deep vasculature of the brain to achieve high-precision measurement of its activity. This technological advancement can be of great importance for the understanding of our brain and for the detection and treatment of neurological disorder
Corrigendum to ”Soutter, E. et al. (2024). Exceptional preservation of three-dimensional dunes on an ancient deep-marine seafloor: implications for sedimentary processes and depositional environments”
Get PDFCorrigendum to ”Soutter, E. et al. (2024). Exceptional preservation of three-dimensional dunes on an ancient deep-marine seafloor: implications for sedimentary processes and depositional environments. Sedimentologika, 2(1), 1-18. https://doi.org/10.57035/journals/sdk.2024.e21.1067
Le coût de l’autonomie : la trajectoire des \u27Éditions du Progrès\u27 à l’épreuve de la perestroïka et la transition post-socialiste, 1986-1996
No full textThis paper examines the transition of the Soviet publishing system from a highly centralized and controlled socialist to a market-based model between the late 1980s and the mid-1990s. The study focuses on the case of ‘Progress Publishers’ [Издательство Прогресс] (1963-1996), the only publishing house specialized in translating Soviet literature into foreign languages for export, which had successfully reinvented itself as the main promoter of the glasnost movement within the publishing field in the USSR during the perestroika years. Through its political engagement in support of the reforms and its quest for professional autonomy, this publisher contributed to the democratization of the public sphere and the destatization of the publishing sector in the country. The article thus examines the social and political conditions as well as the actors’ strategies that made this conversion possible, drawing on archival sources, specialized press, memoirs by former managers of the publishing house and semi-structured interviews. The aim of this study is to contribute to recent research into the historical sociology and intellectual history of publishing in Russia, and to shed light on the crucial period of transition from a Soviet to a post-Soviet context.Cet article examine la transition du système éditorial soviétique, passé du modèle socialiste ultra-centralisé et contrôlé à celui du marché entre la fin des années 1980 et le milieu des années 1990. L’étude se concentre sur le cas des ‘Éditions du Progrès’ [Издательство Прогресс] (1963-1996), seule maison d’édition spécialisée dans la traduction de la littérature soviétique vers les langues étrangères destinée à l’export, qui a réussi à se réinventer en promotrice principale du mouvement de la glasnost au sein du champ éditorial en URSS pendant les années de la perestroïka. Par son engagement pour les réformes et sa quête d’autonomie professionnelle, la maison a contribué à la démocratisation de la sphère publique dans le pays ainsi qu’à la désétatisation du secteur éditorial. L’article s’intéresse aux conditions sociopolitiques et aux stratégies d’acteurs ayant permis une telle reconversion, en s’appuyant sur des sources archivistiques, des articles de presse spécialisée, des mémoires d’anciens responsables de la maison d’édition et des entretiens semi-directifs. Cette étude entend ainsi contribuer aux recherches récentes sur la sociologie historique et l’histoire intellectuelle de l’édition en Russie et apporter un éclairage sur la période cruciale du passage d’un contexte soviétique à celui post-soviétique
Paraska Tolan-Szkilnik (2023) - Maghreb Noir: The Militant-Artists of North Africa and the Struggle for a Pan-African, Postcolonial Future
Get PDFCritical review: Paraska Tolan-Szkilnik, Maghreb Noir: The Militant-Artists of North Africa and the Struggle for a Pan-African, Postcolonial Future, Redwood City, Stanford University Press, 2023, 272 p.Recensé : Paraska Tolan-Szkilnik, Maghreb Noir: The Militant-Artists of North Africa and the Struggle for a Pan-African, Postcolonial Future, Redwood City, Stanford University Press, 2023, 272 p
L\u27action du Syndicat des cheminots éthiopiens (1946-1977): Anti-colonialisme, luttes sociales et défense des travailleurs
No full textIn 1946, Ethiopian railway workers at the Franco-Ethiopian Railway Company mobilised against workplace discrimination. They formed the country’s first trade union, which initially collaborated with the Ethiopian government in support of a nationalist project. However, this common ground did not last, and tensions peaked after the nationalisation of the company in 1960, until both the company and the union disappeared at the end of the 1970s. During its thirty years of existence, the Ethiopian Railwaymen’s Union combined collective action – sometimes violent – with daily efforts to defend individual employees. Their examination offers insight into the way trade unionism was perceived in Post-World War II African society.En 1946, les cheminots éthiopiens de la Compagnie du chemin de fer franco-éthiopien se mobilisent contre les discriminations internes à l’entreprise. Ils constituent alors la première organisation syndicale du pays, qui agit d’abord de concert avec le gouvernement éthiopien en soutien à un projet nationaliste. Mais les intérêts divergent rapidement, et définitivement après la nationalisation de la compagnie en 1960, jusqu’à la disparition de la société et du syndicat à la fin des années 1970. Durant ses trente ans d’existence, le Syndicat des cheminots éthiopiens combine des actions collectives, parfois violentes, et une pratique quotidienne de défense individuelle des salariés de l’entreprise. Leur description nous informe sur la façon dont le syndicalisme est appréhendé par une société africaine après la Seconde Guerre mondiale