UNIFRAN - Publicações Acadêmicas (Univ. de Franca)
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Computational study of reaction mechanism and confinement effects in C-C coupling reactions catalyzed by zeolites
No full textThe increasing energy demand and sustainable development is requiring that new methodologies for power generation and building blocks for industrial applications have to be created. Therefore, methane usage to these applications shows to be very promising due to its abundance and easy achievement.Both methane and carbon dioxide are Greenhouse gases that are involved in several human activities. Thus, new methodologies to remove such gases from atmosphere are extremely important. Molecules with economical interest like ethylene and acetic acid can be obtained by C-C coupling reactions involving CH4 and CO2.In this work we studied computationally the reaction mechanisms involved in C-C coupling reaction of methane molecules using modifield SSZ-13 zeolites as catalysts
Heck arylation of acyclic olefins employing arenediazonium salts and chiral N,N ligands: New mechanistic insights from quantum-chemical calculations
No full textA quantum-chemical study based on the Kohn-Sham density functional theory (DFT) has been performed in order to investigate the asymmetric Heck-Matsuda (HM) reactions involving the chiral N,N ligand pyrimidine-oxazoline. The first step of oxidative addition (OA) of arenediazonium was analyzed to provide further insights on the unexpected high reactivity of N,N-ligated palladium(0) based catalysts observed in these HM processes. DFT calculations suggest that the increasing of ionogenic nature of metal center promoted by the arenediazonium cation addition improving the electronic reactivity of palladium(0) towards the donor N,N ligand. The enantioselectivity is controlled by the combination of steric and dispersion interactions between ligand and substrate. DFT predictions on the selectivity shown to be in quantitative agreement to the experimental findings
PSEUDO-HERMAFRODITISMO MASCULINO E NEOPLASIA TESTICULAR EM UM CÃO: RELATO DE CASO
No full textO objetivo deste estudo foi relatar o caso de um cão macho de dez anos, Poodle, que atendido no Rio de Janeiro/RJ, com massa abdominal, criptorquidismo unilateral e anormalidades da genitália externa. O exame ultrassonográfico mostrou uma massa de 6,2 cm de diâmetro na região meso / hipogástrica e uma estrutura tubular adjacente. Após os exames laboratoriais, o animal foi submetido a orquiectomia pré-escrotal unilateral esquerda e laparotomia exploratória, onde foi encontrado testículo criptorquídeo direito com estrutura tubular semelhante aos tubos uterinos, conectando ambos os testículos. O exame histológico das gônadas revelou gonadoblastoma no testículo criptorquídeo, enquanto o tópico apresentou seminoma intratubular. A estrutura tubular encontrada demonstrou morfologia uterina e nenhum tecido ovariano foi encontrado na peça cirúrgica. A presença de gônadas masculinas e tubos uterinos femininos indicam um caso de pseudo-hermafrodita masculino. Pseudo-hermafroditismo em cães é uma doença genética e a reprodução sexual deve ser evitada. Constata-se que a correção cirúrgica é fundamental para a manutenção das características fenotípicas, além de permitir que o animal tenha uma vida normal; e que o exame físico, o tratamento cirúrgico e a análise histológica são essenciais para o diagnóstico de pseudo-hermafroditismo. No entanto, outras evidências, tais como análises hormonais e citogenéticas, podem ser realizadas para melhorar o diagnóstico
Artigo de Revisão - Tumor Venéreo Transmissível Canino
No full textResumo: O tumor venéreo transmissível canino (TVTC) pode ser considerado uma das neoplasias mais comuns nesta espécie. Morfologicamente classificado como neoplasia de células redondas, acomete principalmente a mucosa genital externa de cães. A transmissão decorre da implantação de células tumorais durante o coito, brigas ou interações entre animais portadores e susceptíveis. Este tumores podem ser encontrados em locais atípicos, no entanto, as metástases raramente ocorrem. O diagnóstico é realizado pelos sinais clínicos e análise citológica, mas em casos particulares a histopatologia e imuno-histoquímica podem ser necessárias. O tratamento de escolha baseia-se na monoquimioterapia com sulfato de vincristina. Com isso, objetivou-se por meio dessa revisão, reunir informações para maior compreensão dos tumores transmissíveis, alertando sobre as complicações que podem ser encontradas
RUMENOSTOMIA GUIADA POR ENDOSCÓPIA ORO-RUMENAL: ESTUDO EM MODELO EXPERIMENTAL
No full textO trabalho objetiva descrever uma técnica minimamente invasiva de rumenostomia através do uso do endoscópio flexível. Realizou-se um estudo piloto em caráter de modelo experimental, em bezerros oriundos de frigoríficos da região, onde os mesmos foram posicionados em decúbito lateral direito para possibilitar o acesso ao rúmen. O endoscópio foi inserido pela cavidade oral do animal, e através de uma iluminação transabdominal e com insuflação, por palpação do flanco se conseguiu estabelecer o locar exato para inserção um mandril (Cateter 18G) para passagem do guia da sonda. Pelo mandril se passou o fio guia de nylon 0,60 mm, apreendido pela pinça, passada pelo canal de trabalho do endoscópio. O guia foi levado até a boca do modelo experimental e sua extremidade foi fixada a uma sonda uretral de número 16. A mesma foi guiada até o local onde se encontrava o cateter e foi realizada uma pequena ampliação para a passagem da sonda. Em seguida, fixou-se a sonda. Conclui-se que é possível a realização da rumenostomia minimamente invasiva utilizando o endoscópio flexível, e recomenda-se o seu uso, diminuindo assim os agravos a qual o paciente é submetido, prezando pelo seu bem estar, sendo importante também no tratamento e em estudos envolvendo o trato digestório de ruminantes
EFFECT OF VULCANIZATION INTO SYNTHETIC RUBBERS: CHEMICAL AND MECHANICAL STUDIES
No full textPurposes: The footwear sector has become an important social and economic factor worldwide. One of the main products generated in this footwear sector is rubber. One of the most widely used methods to rubber manufacturing is the vulcanization, where it is characterized by crosslinking of sulfur in the rubber structure thereby giving greater strength and elasticity to the material. Thus, this project proposes the thermo-structural study of synthetic rubbers produced in an industry of the Franca city. Objective/Methods: For this, a systematic study will be carried out to verify the changes in the thermal and structural properties, comparing vulcanized and unvulcanised synthetic rubbers. Conclusions: The techniques of Infrared Spectroscopy by Fourier Transform (FTIR) and thermal analysis (TG/DSC) will be used for this purpose in order to verify the influence of the sulfur on the thermal stability of these rubbers and the possible structural changes.Keywords: Rubber, Vulcanization, chemical stability, mechanical properties.Acknowledgments: UNIFRAN, FAPESP, CAPES and CNPq
DIAGRAMMING AND DESIGN OF INVESTIGATION JOURNAL
No full textDIAGRAMMING AND DESIGN OF INVESTIGATION JOURNAL[c1] [RF2] TA Teodoro¹; LZ Crivellenti¹.¹Universidade de Franca, Franca-SP.E-mail: [email protected] Purpose: The aim of this study was to modify the layout and design of the Investigation Journal, ranging from the choice of colors, layout and text hierarchy, as well as the entire finalization process for the submission and publication of articles. Methods: The project of the Investigation Journal was created by the Unifran Veterinary and the Graphic Design College. A PIBIC [RF3] was choose to improve Journal´s Layout and development of articles publication. Results: The layout, color choices, text layout and images have been performed by the Design group to be intuitive and ease to read. Also, its rapid response in commands makes it the most requested for editorial work, with it is always possible to update or change a certain project in a matter of few hours. Conclusions: The pibic scholarship proved to be effective for design and layout of the journal, and its maintenance is essential.Keywords: Design, journal, layoutFinancial support: CNPq, Unifran
LEARNING CURVE EVALUATION FOR LAPAROSCOPIC GUIDED RENAL BIOPSY
No full textPurpose: It’s proposed with the present study to evaluate how many biopsies by the technique of videoscopia should be performed for the professional becomes able to perform such technique with greater safety, obtaining samples of high quality, all in a shortest possible time, measuring and evaluating the scale necessary for the professional to reach a fixed plateau. Methods: 12 corpses of dogs weighing less than 10 kg will be used, coming from the pathology sector of the Veterinary Hospital of the University of Franca (UNIFRAN). The cadavers will be submitted to laparoscopy followed by video-assisted renal biopsy for collection of fragments and subsequent histopathological analysis. In the statistic will be evaluated the interactions between the number of glomeruli at each repetition, the time of execution, presence of artifacts and presence of renal medulla, by means of mixed regression model with the random effect of individual. Results: To date, the procedure was carried out in two cadavers, with 80 samples being analyzed to verify the sample quality, the percentage of glomeruli, the medullar portion and the presence of artifacts, with the participation of 4 different operators in this first step. Conclusion: In the samples already analyzed, a relative number of glomeruli with a low percentage of marrow and some artifacts was verified, but more experiments are required to begin the establishment of the learnig curve
USE OF PERACTICAL ACID IN THE DISINFECTION OF FUNGAL BIOFILMS IN HEMODIALYSIS EQUIPMENTS
No full textPurpose: Although the standardization of disinfection processes by national and international organizations, there is a contamination of dialysis machines caused by fungus, especially in the biofilm growth (microorganisms held together by exopolymeric substance and adhered to a surface), has increased patient's risk of acquiring infection. In addition, concentration of nutrients in the ambient, salinity, pH and oxygenation modulate the biofilm formation. The anti-biofilm activity of peracetic acid, a disinfectant recently introduced for the disinfection of hemodialysis machines, against Fusarium biofilms was evaluated under two oxygenation conditions. The concentrations tested were 0.1% and 0.2%, with 30 minutes and 10 minutes exposure duration, respectively. Methods: The biofilms were formed in microaerophilic and aerophilic conditions in 96-well microplates at 30 ° C for 72 hours, determining their cell viability by the tetrazolium salt reduction assay (XTT). Results: The results showed that 0.2% peracetic acid during 10 minutes effectively reduced the metabolic activity of Fusarium biofilms (p<0.05). Comparative analysis between aerophilia and microaerophilia showed higher efficiency for the microaerophilic condition (p <0.001). Conclusion: The 0.2% peracetic acid with a 10 min-exposure time showed to be a potent agent for disinfection of the dialysis machines infected with Fusarium biofilms. Disinfection efficiency can contribute to a better quality of life for patients who require renal replacement therapy, as well as reduce the costs of the public health system, reducing hospitalization for infection
INFRARED THERMOGRAPHY OF THE BODY SURFACE OF SHEEPS SUBMITTED TO LAPAROSCOPY AND DEEP TRENDELENBURG POSITIONING
No full textThe aim of this work was to evaluate the temperature variation in sheeps submitted to videolaparoscopy and deep trendenlerburg positioning using infrared thermography. For that purpose, eight animals will be anesthetized, placed in deep Trendelenburg positioning (45°), have their abdomens inflated with CO2 and then submitted to videolaparoscopy. The animals will be randomly allocated into two groups: G1 (n=4) no inclination and G2 (n=4) deep trendelemburg positioning (45°). Infrared thermography will be evaluated in the following regions: ocular surface, head and distal portion of the thoracic and pelvic limbs Physiological parameters will be collected before each thermographic evaluation at 15 min intervals, during 60 minutes. Data will be submitted to normality test and expressed in means ± standard deviation. Thermographic results from different regions and intervals will be compared by ANOVA, followed bypost-test of Tukey (P <0.05). Chi-square test will be used to compare groups. All analyses will be evaluated by tatistical program Bio Statis 5.0®Key words: Advanced diagnosis, Cefalodeclive, Ewe, Temperature, Videosurgery.Approval CEUA:.9157170517Acknowledgments: PIBIC CNPq