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DNAアプタマーを用いた抗体医薬品のバイオアナリシスおよびプロセスアナリシスのための新規Ligand Binding Assay法の開発
Get PDF静岡県立大学博士 （薬科学）2024application/pdfdoctoral thesi
Synthesis of Aryl and Alkyl Sulfonyl Cyanides Using KCN and NaOCl·5H2O in a Biphasic System
Get PDFapplication/pdfAn efficient and practical protocol has been developed for synthesizing aryl and alkyl sulfonyl cyanides (R–SO2CN) from sodium sulfinates (R–SO2Na) by employing potassium cyanide (KCN) and sodium hypochlorite pentahydrate (NaOCl·5H2O) under weakly acidic conditions. A biphasic medium is essential for suppressing side reactions and enabling broad generality including 13C-labeled derivatives. In situ-generated cyanogen chloride (ClCN) was identified experimentally as the key reactive species. The synthetic utility is showcased through the enhanced reactivity of electronically tuned sulfonyl cyanides in useful transformations.journal articl
Spiritual Care and Ordinary Mutual Care from the Perspective of Peircean Semiotics: On the Triadic Structure of Meaning, Interpretation, and Response
Get PDFapplication/pdfdepartmental bulletin pape
