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The Anxieties and Coping Behaviors of Non-native Japanese Language Teachers: A Case Study of Part-time Lecturers Working at Universities
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The Possible Restraint Imposed on the Activities of the International Criminal Court by Article 98 Agreements, Extradition Treaties, and Status of Forces Agreements (SOFAs): An Analysis of their Consistency with the Rome Statute and the Related Issues of the Law of Treaties (V/Final)
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Religion and American Foreign Policy: In the Context of Historiographical Overview and Policy Formation
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A study of pill bugs and a proposal for its use in children's education
Get PDFapplication/pdf今日、自分で考える力を育成する教育が求められている。ダンゴムシは子供達の関心が高く、児童、生徒の自由研究などの多くの研究対象となっている。今回、ダンゴムシの食性に関する児童、生徒の研究結果およびネット情報の数件について検証実験を行った。その結果、児童、生徒の研究結果やネット情報の中には、今回の研究結果と一致しないものがあり、これらの情報の修正が必要であることが示唆された。不正確な情報は、間違った印象を子供に与えてしまう可能性があり、再現性のある確かな情報が提供されることの必要性が感じられた。ダンゴムシの研究は、すでに宮崎県の中学校において選択理科の授業の中で実施され一定の成果が認められており、児童、生徒の生物教育に有効であると考えられる。児童、生徒の研究成果を集積できる科学雑誌などのプラットフォームを用意して、
論文発表の機会ができれば、論文作成などの教育にも役立つことになる。Today, there is a demand for education that fosters the ability to think for oneself. The Japanese pill bugs are of great interest to children, and have been the subject of much research, including free research by children and students. In this study, we conducted an experiment to verify the results of students' research on the feeding preference of the pill bugs, as well as information on the Internet. As a result, it was found that some of the study results reported by students were not in agreement with those of the present study, and that the inaccurate information on the Internet needs to be modified. Inaccurate information may give children wrong impressions, and therefore, providing reproducible and reliable information should be important. A platform such as a science journal would contribute to such a purpose. The study on the pill bugs has already been conducted in a science class at a junior high school in Miyazaki Prefecture with certain successful results, suggesting its
effectiveness for the biological education of children and students. This publication platform would be useful to accumulate the research results of children and students and to contribute to education through experience of writing papers.application/pdfjournal articl
Mass spectrometric analysis of the amiodarone-induced alteration of phosphatidylcholines in living single cells
No full textapplication/pdfAmiodarone is one of the cationic amphiphilic drugs which cause the drug-induced phospholipidosis (DIPL). With the accumulation of phospholipids, the multiple-membrane structures called lamellar bodies emerge in the cell. Since the pathogenesis mechanism has not been clarified yet, DIPL is still concerned in the clinical use of amiodarone and the new drug development processes. In this study, we have focused on phosphatidylcholines (PCs) which are the representative phospholipids and have developed a single-cell analytical method for the determination of PCs accumulated in the lamellar bodies. By a nanoelectrospray ionization-tandem mass spectrometry (nanoESI-MS/MS), PCs were sensitively and selectively detected at a single-cell level with their product ions of m/z 184. The amounts of PCs increased in the amiodarone-treated cells, and some of them were found higher in the lamellar bodies than in the cytoplasm. The exact mass analysis by a high-resolution mass spectrometry and the identification of the side chains of PCs revealed that the two PCs of PC34:1 (16:0_18:1) and PC32:0 (16:0_16:0) may accumulate in the lamellar bodies. The developed method can be applied to the regioselective analyses of other phospholipids and metabolites at a single-cell level and is promising to clarify the mechanism of DIPL.journal articl