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The report of the Referee school in Tohoku Intercollegiate Volleyball Leaguein 2021 －The research by the questionnaire of the Referee school－
Full text linkdepartmental bulletin pape
Educational Effects of Lectures on Drug-induced Suffering at first-year students of Tohoku Medical and Pharmaceutical University
Full text linkLearning about the circumstances that led to drug-induced suffering in the past is important to create a society without such suffering in the future. As some students have never heard of the thalidomide tragedy or HIV-tainted blood scandal that occurred before they were born, the importance of learning about drug-induced suffering is growing every year. In educational settings where the generation of students regularly changes, lectures based on the same curriculum do not necessarily have the same educational effects. Therefore, it is desirable to evaluate and improve education curricula on a regular basis. This study examined the educational effects of lectures on drug-induced suffering for students in their first year at Department of Pharmaceutical Science, Faculty of Pharmaceutical Science of Tohoku Medical and Pharmaceutical University.
The educational effects were evaluated by quantitative text analysis of student reports on drug-induced suffering after the lectures.
Students who described in their reports: the drugs responsible for drug-induced suffering; people and organizations involved in these cases; and tragic situations that resulted, accounted for more than 50% in all cases. In contrast, the rate of students who mentioned laws and relief systems related to drug-induced suffering did not reach 10%.
The results demonstrated that the lectures on drug-induced suffering given at our university were highly effective to learn about the circumstances that led to such suffering, but less effective to learn about systems to prevent such cases and provide relief for victims. This point needs to be improved in the future.departmental bulletin pape
Does Simple Sound Stimulation Improve Attention? The Potentials of Binaural Beat Stimulation
Full text linkWhen two slightly different frequency tones are presented separately to the left and right ears, the listener perceives a single tone that varies in amplitude at a frequency equal to the frequency difference between the two tones. This perceptual phenomenon is known as binaural beats. Here, we reviewed the literature examining the effects of binaural beat stimulation（BBS）on attention. We confirmed the positive effects of gamma-range BBS on the attentional blink test, which requires focused and alternated/divided attention across different papers. No consistent BBS results were observed in studies using vigilance tests to test sustained attention. To resolve this controversy, we propose several requirements that future studies on the effects of BBS on sustained attention should meet. This review will help ensure that the effectiveness of BBS and its limitations are properly and scientifically verified.departmental bulletin pape
An attempt to create a diagnostic algorithm in Parkinsonʼs disease‒related disorders using quantitative variables of nuclear medical imaging
Full text linkObjective: To create a diagnostic algorithm and evaluate severity using nuclear medical imaging in patients with Parkinsonʼs disease（PD）-related disorders.
Methods: Forty-seven patients with PD, 17 patients with progressive supranuclear palsy（PSP）, and 5 patients with multiple system atrophy（MSA）were studied. By applying a machine learning method to data from meta-iodobenzylguanidine（MIBG）myocardial scintigraphy or dopamine transporter（DAT）scintigraphy, we tried to create a diagnostic algorithm to assist in the differential diagnosis of patients with PD, PSP, and MSA. We also searched for quantitative values in these images that could reflect the severity of PD-related disorders.
Results: The three disease groups were not significantly different in age, gender, disease duration, or severity. Compared to patients with PSP and those with MSA, patients with PD had a significantly reduced heart/mediastinum（H/M）ratio in early and/or delayed images on MIBG myocardial scintigraphy. A differential diagnostic algorithm using MIBG myocardial scintigraphy showed that all patients with an H/M ratio（early image） of less than 2.36 and a washout rate of 31.2 or more had PD. In contrast, all patients with PSP had an H/M ratio （early image）of 2.36 or higher. In building an algorithm for differential diagnosis using DAT scintigraphy, we found that more than half of patients with PSP had a specific binding ratio（SBR）of less than 2.615, and the frequency was higher in PSP than in the other two diseases. The severity of PD-related disorders was not significantly correlated with any other variable except the degree of SBR.
Conclusion: Nuclear medical imaging might be useful in the establishment of a diagnostic algorism and severity assessment of PD-related diseases.departmental bulletin pape
Functional analysis of α1,6-Fucosyltransferase(FUT8)in pancreatic carcinoma cell lines
Full text link東北医科薬科大学博士（薬科学）令和3年度doctoral thesi
The Significance of Introducing e-Learning Materials to University English Education and Issues in Post-COVID
No full textdepartmental bulletin pape
A case of post COVID-19 Guillain‒Barre syndrome with treatment-related fluctuation
Full text linkBackground: In recent years, reported cases of Guillain-Barre syndrome（GBS）following COVID-19 infection have been accumulating, but their pathogenesis has not been elucidated. Here, we present a rare case of GBS following COVID-19 infection that was accompanied by treatment-related fluctuation（TRF）．
Case presentation: A 30-year-old man was referred to our department due to diplopia, numbness in the extremities, and weakness in the right hand and both legs that developed 18 days after COVID-19 infection. A neurological examination revealed left ptosis, mild abduction restriction of the left eye, and horizontal diplopia. Muscle weakness was observed in both the upper and lower limbs, and the deep tendon reflexes of the extremities were absent. The patient also had abnormal sensations in the extremities that had a glove and stocking distribution. Based on the clinical course and the results of his laboratory tests, nerve conduction study and spinal cord MRI findings, we diagnosed him with axonal-type GBS. Later, his anti-GM1 antibody was found to be weakly positive. Although the initial treatment with intravenous immunoglobulin（IVIG）was effective, TRF was thereafter observed. His symptoms did not improve after a second course of IVIG and additional treatments with steroid pulse therapy. However, after the administration of plasma exchange, he recovered gradually, and no further relapse was observed. Conclusion: Although rare, GBS following COVID-19 infection can also be complicated by TRF. Furthermore, post COVID-19 GBS with TRF can presents as axonal type.departmental bulletin pape