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Regulatory mechanism of Focal-adhesion kinase on sialylation of N-glycans
Full text link東北医科薬科大学博士（薬科学）令和5年度doctoral thesi
Attitude towards linkage between maternal and child health information and school health information: responses among participants in a birth cohort study
Full text linkIn recent years, with advances in information technology, the use of personal health records from birth through the rest of life has come to be advocated. Therefore, it is essential to understand the current status of people's awareness of this issue. The purpose of this study is to investigate the attitudes towards linking maternal and child health information with school health checkup information, by asking participants of birth cohort participants. Participants in the BOSHI study, a birth cohort study, were asked by postal questionnaire regarding the linkage of maternal and child health information and school health check-up information and received responses from 366 of the 1203 participants（valid response rate: 30.4%）. A high proportion（more than 75%）felt that maternal and child health information and school health check-up information needed to be linked, while about half of the respondents also felt that confirmation of consent was necessary every time the information was made available. The proportion of those who thought that confirmation of consent was necessary when information was used by external researchers such as universities and companies was more than 65%, which was particularly high. In 2021 compared to 2020, the proportion of those who answered that the information from before conception should be linked increased significantly, and the percentages of those who answered that confirmation of consent was required every time the government or local authorities used their information also increased. While awareness of the importance of health information linkage is high and the range of linkage is expanding, more careful explanations are required for its utilization.departmental bulletin pape
Abstracts of Published Papers and Titles of Papers Presented at Scientific Meeting 【Faculty of Medicine】
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The moderating effects of negative interpersonal events on psychopathic tendencies and internet trolling behaviors
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Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
No full textBcl2-associated athanogene-1 protein (Bag1) acts as a co-chaperone of heat shock protein 70 and heat shock cognate 70 (HSP70/HSC70) and regulates multiple cellular processes, including cell proliferation, apoptosis, environmental stress response, and drug resistance. Since Bag1 knockout mice exhibited fetal lethality, the in vivo function of Bag1 remains unclear. In this study, we established a mouse line expressing Bag1 gene missing exon 5, which corresponds to an encoding region for the interface of HSP70/HSC70. Despite mice carrying homoalleles of the Bag1 mutant (Bag1Δex5) expressing undetectable levels of Bag1, Bag1Δex5 homozygous mice developed without abnormalities. Bag1Δex5 protein was found to be highly unstable in cells and in vitro. We found that the growth of mouse embryonic fibroblasts (MEFs) derived from Bag1Δex5-homo mice was attenuated by doxorubicin and a glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO). In response to BSO, Bag1Δex5-MEFs exhibited a higher dropping rate of GSH relative to the oxidized glutathione level. In addition, Bag1 might mitigate cellular hydrogen peroxide levels. Taken together, our results demonstrate that the loss of Bag1 did not affect mouse development and that Bag1 is involved in intracellular GSH homeostasis, namely redox homeostasis.journal articl
