Tohoku Medical and Pharmaceutical University Academic Repository
Not a member yet
800 research outputs found
Sort by
The Experience and Creativity of a Pharmacist in Home Care: A Sociological Examination of the Life History of Medical Professionals
Full text linkdepartmental bulletin pape
Reports on the 72nd Meeting for Higher Education in Tohoku-Hokkaido area
Full text linkdepartmental bulletin pape
Isolation of Sesquiterpenoids and Trypanocidal Constituents from Artemisia adamsii
Full text linkThe Mongolian Artemisia adamsii (A. adamsii) plant is of particular interest from both medicinal and ecological perspectives. In this study, three previously undescribed sesquiterpenoids (1–3) were isolated, along with 25 known compounds, from naturally dried and browned aerial parts of A. adamsii, which were collected in the autumn from the pasturelands of Bayan Soum, Tuv Province, Mongolia. The chemical structures of the isolated undescribed compounds, including their relative and absolute configurations, were elucidated by high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and single crystal X-ray crystallography. The trypanocidal activities of the isolated compounds against six species, namely Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. equiperdum, Trypanosoma congolense, and Trypanosoma evansi were evaluated. Consequently, a coumarin (fraxetin) and a flavonoid (jaceosidin) were identified as exhibiting relatively potent activities. Quantitative analysis by high-performance liquid chromatography confirmed relatively high contents of these compounds in A. adamsii, indicating that they represent the main functional components of this plant. These results further demonstrate the potential medicinal and ecological significance of A. adamsii.journal articl
Phytochemical and biological investigations of medicinal plants (Woodsia ilvensis, Artemisia sieversiana, and Rheum undulatum) for promoting the health of livestock in Mongolia
Full text link東北医科薬科大学博士（薬科学）令和6年度doctoral thesi
3D structural insights into the effect of N-glycosylation in human chitotriosidase variant G102S
Full text link東北医科薬科大学博士（薬科学）令和6年度doctoral thesi
Mutations in the glycosyltransferase genes involved in glycolipid synthesis and disorders of the biosynthesis
Full text linkGlycosphingolipids are composed of a hydrophobic ceramide portion, in which a fatty acid is bound to a long-chain base called sphingosine, and a hydrophilic sugar portion. Sialic acid-containing glycosphingolipids, called gangliosides, are abundant in the central nervous system, and four species GM1, GD1a, GD1b, and GT1b are predominant in mammalian brains. Both GM3 synthase and GM2/GD2 synthase are essential for the biosynthesis of these four major species. Pathogenic mutations in the genes encoding GM3 synthase（ST3GAL5）and GM2/GD2 synthase（B4GALNT1）are the cause of infantile-onset epilepsy syndrome associated with developmental regression as well as abnormal movements and blindness, and SPG26, a complicated form of hereditary spastic paraplegia associated with intellectual disability and peripheral neuropathy, respectively. In this review, the author summarizes the current understanding of the pathophysiology of glycolipid biosynthesis disorders based on the results of studies using gene knockout mice, and introduces the first cases of ST3GAL5 and B4GALNT1 gene mutations in Japan that have recently been identified in patients with neurological disorders.departmental bulletin pape
Examining community-centred disaster trauma support and brainspotting
Full text linkThirteen years have passed since the Great East Japan Earthquake. The area around the Tohoku Medical and Pharmaceutical University Hospital has changed, showing that it is still in the process of reconstruction. The experience of the disaster is being passed on to the next generation. The psychological trauma of the disaster exists in the area. The author conducted research on visual psychological trauma and visual memory in the affected areas. The author also discussed ways to adapt psychological trauma support to the culture of the Tohoku region. Based on these findings, the author used brain spotting as a treatment for visual psychological trauma. In some cases, talk therapy cannot be adapted to local psychological trauma. Brain spotting as a treatment method for visual psychological trauma has the advantage of reassuring people living in the area.departmental bulletin pape
The epidemiology of post-COVID-19 condition: a Japanese claim database study
Full text linkCoronavirus disease 2019（COVID-19）is an ongoing pandemic, and COVID-19 infection has led to post-COVID-19 conditions. However, an analysis of post-COVID-19 conditions using a real-world database has not yet been reported in Japan. Using Japanese inpatient and outpatient claims databases, we evaluated patients with an ICD-10-CM code for post-COVID-19 condition（U09.9）between November 1, 2021, and May 31, 2023. The main outcome of this study was the symptoms in the same month after post-COVID-19 condition diagnosis. Of the 8,069 included outpatients with post-COVID-19 conditions, the median age of these patients was 54.0 years（interquartile range: 36.0−76.0 years）, with males including 50.1%. The patients were divided into three groups according to age: 486 patients aged 0−17 years, 4,512 patients aged 18−64 years, and 3,071 patients aged >65 years. The rates of post-COVID-19 conditions diagnosed in outpatient department were 72.6%. Among complications, respiratory complications（40.7%）were the largest number of complications in the same month of post-COVID-19 diagnosis, followed by sleep disorders（15.8%）, malaise and fatigue（7.3%）, and headache（7.1%）. In conclusion, we assessed the symptoms of post-COVID-19 conditions using a Japanese claims database. Additional follow-up studies using other data sources as databases are required.departmental bulletin pape
