Repository of Shinshu
Not a member yet
23655 research outputs found
Sort by
釈論大江千里集（十）
No full textThis paper is an investigation and interpretation (釈論) of ‘Oe no Chisato-shu’ (大江千里集) which is an anthology of Waka (和歌＝ancient Japanese poems) by Oe himself.In this anthology, as usually called Kudai-waka (句題和歌), each Waka is given one phrase poetic title from Kanshi (漢詩＝ancient Chinese poem) selected by Oe.The authors of this paper think that the mutual relations between expressions in both Waka and Kanshi have various patterns. So，the central purpose of our investigation is to concretely explicate the actual condition of all these patterns． And first,this paper treats of Waka No.36～No.40 of ‘Oe no Chisato-shu’.application/pdfdepartmental bulletin pape
タイ、チョンブリ県における町ぐるみ高齢者ケア・包括プロジェクト : サンスク町をパイロット地域として(第2報)
No full text佐久市・佐久大学は、2016年1月25日～2018年12月31日までJICA（（独）国際協力機構）より草の根技術協力事業（2014年度地域活性化特別枠）「タイ、チョンブリ県における町ぐるみ高齢者ケア・包括プロジェクト―サンスク町をパイロット地域として―」を受託し実施した。プロジェクトの成果目標は、1．高齢者保健医療・介護推進委員会が設置される。2．訪問ケアが企画され実施される。3．地域保健委員会が再編される。4．お寺単位の介護予防活動が改善される。5．佐久市で研修を受けた看護師、理学療法士、ヘルスボランティアが訪問ケアおよび地域活動に貢献する。本プロジェクトの概要、および2017年9月末までの活動について、第1報として昨年の佐久大学紀要（佐久大学看護研究雑誌11巻1号2019年）に活動報告を掲載した。本第2報では、在宅ケアの仕組みづくり、中間評価の結果、住民の健康意識の向上を目指してプロジェクトの主な活動の1つとして位置付けてきた「バンセン・ヘルスフェスティバル」の開催、最終評価のまとめを報告する。Saku city and Saku University have implemented JICA Partnership Project, “Community-based Comprehensive Elderly Care Project in Chonburi Province, Thailand: Project in Saensuk Municipality as a Pilot Area. Its execution period was from Jan., 2016 to Dec., 2018. Five expected outcomes of the project were: 1. To establish Health, Medicine and Welfare Committee for the elderly care, 2. To make a plan of home-care services and its implementation by nurses and health volunteers, 3. To reform Community Health Committee for organizing systematic community activities, 4. To improve health promotion exercises at local temples targeting the elderly people, 5. To encourage positive contribution to home-care services and community activities by nurses, physical therapists and health volunteers who were trained in Saku city. Outline of the project and activities from Jan. 2016 to Sep.31, 2017 were reported in Saku University Journal 11-1.（2019）. As the 2nd report, we describe establishment of home-care service system, results of mid-term evaluation, the 1st Bansaen Health Festival and final evaluation points.departmental bulletin pape
High-Speed Asymmetric Motion of Thermally Actuated Cilium
No full textMicroorganisms can generate net flows effectively even in a low Reynolds number regime by using asymmetric beating motion of hair-like cilia. Here, we demonstrate a high-speed novel artificial cilium driven by the heat engine using a self-propelled swing motion in a nucleate- to film-boiling regime. In particular, we report the asymmetrical motion of the thermal cilium with an asymmetric joint structure. We believe that our thermal cilium opens a new way to develop a microfluidic circuit.ArticleJOURNAL OF THE PHYSICAL SOCIETY OF JAPAN.89(11):114402(2020)journal articl
Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway
No full textThe nuclear receptor superfamily includes ligand-inducible transcription factors that play diverse roles in cell metabolism and are associated with pathologies such as cardiovascular diseases. Lysophosphatidic acid (LPA) belongs to a family of lipid mediators. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and an intracellular nuclear hormone receptor. In addition, several enzymes that utilize LPA as a substrate or generate it as a product are under its regulatory control. Recent studies have demonstrated that the endogenously produced peroxisome proliferator-activated receptor gamma (PPAR gamma) antagonist cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPAR gamma function by stabilizing the binding of the co-repressor protein, a silencing mediator of retinoic acid, and the thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPAR gamma target gene transcription. The present review discusses the arbitrary aspects of the physiological and pathophysiological actions of lysophospholipids in vascular and nervous system biology.ArticleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18(12):2730 (2017)journal articl
Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice
No full textPurpose: Multiwalled carbon nanotubes (MWCNTs) have been known to enter the circulatory system via the lungs from inhalation exposure; however, its carcinogenicity and subsequent accumulation in other organs have not been adequately reported in the literature. Moreover, the safety of MWCNTs as a biomaterial has remained a matter of debate, particularly when the material enters the circulatory system. To address these problems, we used carcinogenic rasH2 transgenic mice to intravenously administer highly dispersed MWCNTs and to evaluate their carcinogenicity and accumulation in the organs. Methods: Two types of MWCNTs (thin-and thick-MWCNTs) were intravenously administered at a high dose (approximately 0.7 mg per kg body weight) and low dose (approximately 0.07 mg per kg body weight). Results: MWCNTs showed pancreatic accumulation in 3.2% of mice administered with MWCNTs, but there was no accumulation in other organs. In addition, there was no significant difference in the incidence of tumor among the four MWCNTs-administered groups compared to the vehicle group without MWCNTs administration. Blood tests revealed elevated levels in mean red blood cell volume and mean red blood cell hemoglobin level for the MWCNTs-administered group, in addition to an increase in eotaxin. Conclusion: The present study demonstrated that the use of current technology to sufficiently disperse MWCNTs resulted in minimal organ accumulation with no evidence of carcinogenicity.ArticleINTERNATIONAL JOURNAL OF NANOMEDICINE. 14:6465-6480 (2019)journal articl
Spectral form factor and semi-circle law in the time direction
No full textWe study the time derivative of the connected part of spectral form factor, which we call the slope of ramp, in Gaussian matrix model. We find a closed formula of the slope of ramp at finite N with non-zero inverse temperature. Using this exact result, we confirm numerically that the slope of ramp exhibits a semi-circle law as a function of time.ArticleJOURNAL OF HIGH ENERGY PHYSICS.(2):161(2019)journal articl
Resurgence analysis of 2d Yang-Mills theory on a torus
No full textWe study the large N 't Hooft expansion of the partition function of 2d U(N) Yang-Mills theory on a torus. We compute the 1/N genus expansion of both the chiral and the full partition function of 2d Yang-Mills using the recursion relation found by Kaneko and Zagier with a slight modification. Then we study the large order behavior of this genus expansion, from which we extract the non-perturbative correction using the resurgence relation. It turns out that the genus expansion is not Borel summable and the coefficient of 1-instanton correction, the so-called Stokes parameter, is pure imaginary. We find that the non-perturbative correction obtained from the resurgence is reproduced from a certain analytic continuation of the grand partition function of a system of non-relativistic fermions on a circle. Our analytic continuation is different from that considered in hep-th/0504221.ArticleJOURNAL OF HIGH ENERGY PHYSICS.(8):65(2018)journal articl
Phase diagram of q-deformed Yang-Mills theory on S-2 at non-zero theta-angle
No full textWe study the phase diagram of q-deformed Yang-Mills theory on S-2 at non-zero theta-angle using the exact partition function at finite N. By evaluating the exact partition function numerically, we find evidence for the existence of a series of phase transitions at non-zero theta-angle as conjectured in [hep-th/0509004].ArticleJOURNAL OF HIGH ENERGY PHYSICS.(4):59(2018)journal articl
Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment
No full textEmbryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are potential resources for the regeneration of defective organs, including the liver. However, some obstaclesmust be overcome before this becomes reality. Undifferentiated cells that remain following differentiation have teratoma-forming potential. Additionally, practical applications require a large quantity of differentiated cells, so the differentiation processmust be economical. Here we describe a DNA microarray-based global analysis of the gene expression profiles of differentiating human pluripotent stem cells. We identified differences and commonalities among six human pluripotent stem cell lines: the hESCs KhES1, KhES2, KhES3, and H1, and the iPSCs 201B7 and 243G1. Embryoid bodies (EBs) formed without requiring supplementation with inducing factors. EBs also expressed some liver-specific metabolic genes including the ammonia-metabolizing enzymes glutamine synthetase and carbamoyl-phosphate synthase 1. Real-time PCR analysis revealed hepatocyte-like differentiation of EBs treated with ammonia in Lanford medium. Analysis of DNA microarray data suggested that hepatocyte-like cells were the most abundant population in ammonia-treated cells. Furthermore, expression levels of undifferentiated pluripotent stem cell markers were drastically reduced, suggesting a reduced teratoma-forming capacity. These results indicate that treatment of EBs with ammonia in Lanford medium may be an effective inducer of hepatic differentiation in absence of expensive inducing factors.ArticlePLOS ONE.11(9):e0162693(2016)journal articl