BIOREpository (Faculty of Biology, University of Belgrade)
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IMPORTANCE OF WETLANDS– RAMSAR SITE BARDAČA, CASE STUDY IMPORTANCE OF WETLANDS– RAMSAR SITE BARDAČA, CASE STUDY
No full text5-6pM3
Trojan Female Technique for the biocontrol of the seed beetle Acanthoscelides obtectus: mitochondrial haplotype has negative male-specific effect on fertility across different nuclear backgrounds
No full textThe seed beetle Acanthoscelides obtectus is one of the most economically important pests of stored legume seeds worldwide and is traditionally controlled with synthetic pesticides. However, the frequent use of these toxic compounds leads to environmental and health damage and the evolution of resistant insect populations. The Trojan Female Technique (TFT) is a novel species-specific, transgenerational biocontrol method for pest management. Sustained population control is achieved by releasing of Trojan females (TF) that carry naturally occurring mitochondrial DNA mutations (TFT mutation) that impair male fertility, but have no effects on females. TF and their female offspring could continuously, over multiple generations, produce males that sire fewer offspring than their wild-type counterparts. A candidate TFT mutation that causes male-only subfertility was recently described in A. obtectus. However, the applicability of TFT depends on mitochondrial TFT mutations whose male-sterilizing effects are general across different nuclear genomic contexts. We tested this assumption by expressing the candidate TFT mitochondrial haplotype alongside a range of three nuclear backgrounds and comparing its fertility in males with that of control haplotypes. We found that the fertility of males harbouring the candidate TFT mutation is consistently lower in all three nuclear backgrounds.M3
Exploring thyroid effects and gender-specific responses to pseudomonas aeruginosa mannose- sensitive-hemagglutinin (PA-MSHA): a rat model study
No full textM3
Insulin and Glucagon colocalization in Rat Langerhans Islets: Hormone Detection by Immunogold Method
No full textp110M3
Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
No full textMetals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting "no-threshold" concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.M21a7,7118680252Pt
Understanding the natural activation mechanism of the CRISPR-Cas immune system in Escherichia coli: A Computational Modeling Perspective
No full textM321
Honeybees as effective biomonitors of spatial and temporal pollution
No full textBook of Abstracts, 49M3
Health Risk Assessment of Rare Earth Elements in Road Dust near Coal-Fired Thermal Power Plants
No full textBook of Abstracts, 134M3
Fennel (Foeniculum vulgare Mill.) essential oil: The chemical profile, biological activity, and utilization of the commercial products
No full textLaboratory-isolated essential oils are commonly used in experiments regarding their utilization as natural antioxidant and antimicrobial agents. This study analyzed commercially available essential oils (Serbian-FSR and Russian-FRU) of fennel (Foeniculum vulgare Mill.) and added to the pork patties to investigate their possible role as natural antioxidant and antimicrobial agents. Chemical analysis of the samples showed significant differences in profiles caused by geographical origin and other environmental factors. The main compound in both samples was trans-Anethole, but it had a much higher content in Serbian oils. On the contrary, Russian oil had a high portion of anisaldehyde and linalool. These diversities are the main reason for thermal behavior and biological activity differences. The thermal analysis has shown that FSR had a crystalline form in the solid state, while FRU had an amorphous form. During heating, in FSR, a single-step weight loss was detected, while in FRU, a two-step weight loss was observed, indicating that, in addition to evaporation, components in FRU interacted with each other, forming lesser volatile molecules. After adding pork patties, Russian oil showed higher potency and better protective behavior than Serbian oil. Moreover, mixtures of these oils were added to the patties samples, and results showed higher potency when compared to individual oil samples. This indicated that minor compounds from both oils interacted and synergistically acted to prolong the shelf life of the meat samples. Commercial essential oils could be successfully utilized to prolong shelf life and provide additional intake of natural compounds significant for the human diet.M215.21049016