BIOREpository (Faculty of Biology, University of Belgrade)
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New records and noteworthy data of plants, algae and fungi in SE Europe and adjacent regions, 22
No full textThis paper presents new records and noteworthy data on the following taxa in SE Europe and adjacent regions: saprotrophic fungi Coronophora gregaria and Teunomyces cretensis, stoneworts Nitella flexilis and Nitellopsis obtusa, mosses Brachytheciastrum olympicum, Buxbaumia viridis and Taxiphyllum densiflium, monocots Dactylorhiza fuchsii, Hydrocharis morsus-ranae, Poa infirma and Poa jubata and dicots Knautia pancicii and Tozzia alpina subsp. carpathica.M230.914716049
Effect of Lead on the Physiological Parameters and Elemental Composition of Pinus sylvestris L. and Picea abies (L.) H. Karst Seedlings
No full textLead (Pb) pollution poses a long-term threat to forest ecosystems, particularly in mountainous areas affected by atmospheric deposition. This study examined the physiological and biochemical responses of juvenile Pinus sylvestris L. and Picea abies (L.) H. Karst seedlings to low concentrations of lead nitrate during early development. Treatments simulated environmentally relevant Pb exposure and focused on pigment composition, oxidative stress markers, soluble protein and proline levels, and elemental content. Both species exhibited hormetic stimulation of photosynthetic pigments at lower Pb concentrations. In P. sylvestris, this effect declined at the highest dose, whereas P. abies maintained pigment levels, suggesting stronger regulatory control. Pb exposure reduced soluble proteins and induced species-specific alterations in MDA and proline levels. Correlation analysis revealed a well-integrated stress response in P. abies, while P. sylvestris showed a more fragmented pattern. Elemental analysis confirmed Pb accumulation primarily in roots, with higher levels in P. sylvestris. Both species experienced reduced root Mg, K, and Mn, indicating ionic imbalance due to Pb2+ interference. Zn content increased in P. sylvestris but decreased in P. abies, possibly reflecting differences in uptake regulation. These species-specific responses support the hypothesis that P. abies activates more effective defense mechanisms against Pb toxicity, while P. sylvestris exhibits a stronger physiological stress response.M212,416
"Exploring biodegradation of microplastics using gut microbiota from freshwater insects
No full textAbstract book, p. 54M3
Harnessing soil microbiota for enhanced soil health and sustainable agriculture: Insights from nutrient-depleted and overloaded fields in Serbia
No full textp. 3323M3
The extracellular matrix glycoprotein tenascin-C supports the enriched environment-stimulated neurogenesis in the adult dentate gyrus of mice
No full textThe extracellular matrix glycoprotein tenascin C (TnC) is implicated in a variety of processes ranging from cell proliferation and adhesion to synaptic plasticity. The contribution of TnC to neurogenesis related processes in the adult hippocampus, however, remains unclear. To address this question, hippocampal sections were immunostained for the proliferation marker Ki67 and for neuroblast marker doublecortin (DCX). Laser scanning confocal microscopy revealed that TnC - deficiency does not alter either the size of Ki67+ or DCX + cellular populations in the subgranular zone (SGZ) compared to the control animals. Super-resolution Airyscan confocal microscopy enabled the investigation of the complexity of dendritic trees of DCX + cells with the analysis of the dendritic tree complexity parameters. The results show that the dendritic tree complexity of developing neurons is not dependent on the presence of TnC. However, reinforcement of adult neurogenesis by the exposure to enriched environment (EE) revealed that TnC- deficient mice have a reduced number of DCX + cells compared to wild type littermates. This study indicates that TnC might not contribute to the basal levels of adult neurogenesis in the hippocampus, while on the other hand it gains importance in the generation of the positive effect of EE.M222.515223277
Protective Effects of Rosa canina Fruit Extract against Kidney Damage Induced by CCl4
No full textThe study explored the nephroprotective potential of Rosa canina (dog rose) ethanolic fruit extract against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats, while also analyzing its phytochemical composition using UPLC-ESI-MS/MS. Male Wistar rats were allocated into five groups: control, R. canina extract alone, CCl4-induced nephrotoxicity, CCl4 with R. canina extract and CCl4 with silymarin. UPLC-ESI-MS/MS revealed 15 compounds in R. canina extract, predominantly anthocyanins, flavonoids, and lycopene. Treatment with R. canina extract significantly ameliorated CCl4-induced kidney dysfunction, abating oxidative stress and inflammation. Enhanced expression of HO-1 (heme oxygenase-1) and Nrf2 (nuclear factor erythroid 2-related factor 2) mRNA in the kidney suggested their involvement in protective mechanisms. Inhibition of HO-1 attenuated R. canina's protective effect against CCl4-induced kidney injury, underscoring the significance of the Nrf2/HO-1 pathway. For further validation, high throughput molecular docking analysis were performed. The docking analysis revealed the interaction between HO-1 and Nrf2 against Pelarginidin, Malvidin and Petunidin. Among all the three compounds, pelargonidin showed the highest binding score of -9.3kcal/mol and -7.7kcal/mol against Nrf2 and HO-1 respectively. In conclusion, R. canina extract, rich in phenolics, exhibited nephroprotective effects via inflammation and oxidative stress attenuation, potentially mediated through Nrf2/HO-1 pathway modulation against CCl4-induced nephrotoxicity.M21a+3.510591
Long-Term Intake of Oleic Acid-Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats
No full textThe debate over the impact of extensive palm oil consumption on human health, driven by its economic affordability, persists due to its high saturated fat content and potential health risks. Conversely, its diverse bioactive compounds offer antioxidant and anti-inflammatory properties. This study seeks to investigate the effects of prolonged palm oil consumption on hypothalamic insulin signaling, inflammation, and oxidative stress markers. Rats were fed either standard chow or a palm oil-enriched diet (POD) for 21 weeks, with the latter diet prepared by soaking standard briquette food in commercially available palm oil. The palm oil used in our study contained slightly more oleic acid than palmitic acid (44.3% and 39.5%, respectively). Prolonged consumption of a diet enriched with 20% of palm oil resulted in obesity in rats, accompanied by concurrent changes in blood lipid content. Additionally, palm oil consumption induced hyperinsulinemia and hyperglycemia, indicating the presence of peripheral insulin resistance. Despite these findings, our study did not reveal differences in hypothalamic insulin resistance between obese and control rats. In the cerebrospinal fluid, insulin concentration remained consistent after palm oil consumption, while glucose levels increased. Hypothalamic gene expression analysis did not show significant changes in the levels of NF-κB, IL-6, IL-1β, and Nrf2 mRNA. Moreover, the activation of insulin receptor and its substrate IRS1, as well as the expression of glucose transporters GLUT1-4 in the rat hypothalamus, remained unaltered. Ex vivo EPR spectroscopy of the obese rat hypothalamus indicated no variations in the total redox status compared to control rats. In summary, our results suggest that long-term consumption of palm oil rich in oleic acid induces obesity but does not significantly impact hypothalamic insulin expression and response, inflammation, or oxidative stress, which at least in part may be attributed to the specific fatty acid composition of the palm oil used. However, the potential contribution of other phytochemicals and bioactive compounds, such as vitamin E, must not be overlooked when interpreting the overall metabolic response to the prolonged palm oil intake.M215.0e7003651
Unbelievably defensible – the volatile secretion chemistry of European Cryptops Leach, 1814 (Chilopoda: Scolopendromorpha: Cryptopidae)
No full textStr. 103M3
The effect of hydrogen (per)sulfide donors on β cells ferroptosis in diabetic conditions
No full textP75
Sant Feliu de Guixols, Spain, 13 – 18 September 2025M3413913
Cell Labeling with Responsive MRI Contrast Agents is Enabled through Solid-Phase Synthesis
No full textBioresponsive or smart contrast agents (SCAs) for magnetic resonance imaging (MRI) can facilitate functional molecular imaging of numerous biological processes. These are MRI probes that alter the MRI signal along with the concentration changes of different biomarkers in their microenvironment, thus enabling the assessment of tissue physiology with high spatiotemporal resolution. One of the common shortcomings of SCA is their structural and functional insufficiency for accumulation in the targeted region, i.e., most frequently internalization into the cells to study the intracellular processes. Here, we report a strategy to prepare a multifunctional SCA that can be successfully incorporated into the cell membrane and internalized. We used the solid-phase synthesis methodology to obtain a trimeric SCA responsive to calcium ions, which bears a hydrophobic tetradecanoyl group to facilitate interaction with primary rat astrocytes. The developed MRI probe maintained high activity, exhibiting high calcium-triggered longitudinal and transverse relaxivity changes. Concurrently, it showed the ability to label the cell membranes and internalize into the astroglial cells while not causing cytotoxicity or affecting the electrophysiology of the cells.M214.01384139336