BIOREpository (Faculty of Biology, University of Belgrade)
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Genetic Variability of Roma Population in Serbia: The Perspective From Uniparentally Inherited Markers
No full textThe Roma represent a widespread ethnic minority in Europe that has a unique genetic ancestry shaped by a string of population bottlenecks, differential gene flow from/to the general population, and founder effects during their migrations. This study aimed to further characterize the diversity of the Roma population in Serbia and assess the substructuring within the population from the perspective of the mtDNA and Y chromosome. The control region of the mtDNA of 269 samples was sequenced, and 27 Y-STRs and 22 Y-SNPs were analyzed in 165 male samples. We classified samples in concordance with the previously published study on Serbian Roma, based on the geographical region of origin and religious affiliation, and evaluated their genetic relationships with Roma and general populations from the countries throughout their migrational route. Despite the dominance of the ancestral lineages in the paternal genetic pool, a higher diversity was noted in the mtDNA pool. Signals of bidirectional local male gene flow were shown by the presence of the haplogroup H-M2972 among the Serbian population and the high frequency of the I-L621 lineage among Roma. Our results highlight intrapopulation substructuring reflected in different proportions of South Asian and heterogeneity of West Eurasian lineages in both markers across different geographical and religious Roma groups. Asymmetrical gene flow was observed within all Roma subpopulations, while the male-biased gene flow was observed only within the predominantly Orthodox group from the central region of Serbia. Our data reveal the diversity of both uniparental pools of Serbian Roma and emphasize the role of religious affiliation in patterns of admixture with the general population.M211.7e70152371
Nationwide SMA Screening in Serbia: Results and Impact After Sixteen Months of the First Genetic Newborn Test. Hall K, Schielen PCJI, Platis D
No full textOral and Poster Abstracts of the 13th ISNS European Regional Meeting.
International Journal of Neonatal Screening. 2025; 11(1):21. Page: 78-79, P82M3
Male-specific leg modifications in five species of European millipedes (Diplopoda, Julida)
No full textM3
Nature-based solutions: the potential of bryophytes for snail repellency in lettuce crop production
No full textDamage in lettuce production caused by burgundy snails has led to an increased use of molluscicidal chemicals, which persist in both the lettuce and the substrate, and accumulate over time with undesirable outcomes in terms of mollusk pest control. Moreover, these chemicals also harm natural snail populations. In this study, the effects of selected bryophyte species extracts and their application concentrations were tested as natural snail repellents. Twelve bryophyte species, eight mosses, and four liverworts were randomly selected, and their ethanolic extracts were applied as burgundy snail repellents in lettuce. Significant antifeeding effects were observed for the liverworts Bazzania trilobata, Plagiochila asplenioides, and Porella platyphylla, as well as for the mosses Fontinalis antipyretica, Mnium stellare, and Neckera crispa. Among these, B. trilobata exhibited the strongest antifeeding effect without negatively impacting lettuce growth and development, as assessed through seed germination, hypocotyl length, and seedling total chlorophyll content. All bryophyte species with significant antifeeding i.e. repellent potential shared similar chemical profiles, characterized by high phenolic and triterpenoid contents and strong antioxidant capacity. The results obtained offer a nature-based solution in lettuce crop protection as well as an eco-friendly alternative in food production.M221,
Meat Industry as Our Best Chance for Controlling Transmission of a Tiny but Deadly Tapeworm
No full textEchinoccocosis is a zoonotic disease which can have severe, even lethal consequences for the host, yet multiple effective means of controlling transmission and thus preventing infection, are available. Echinococcus granulosus and E. multilocularis are the two tapeworm species which are clinically most relevant in Europe and both are endemic in the Balkans. The life cycle of the tapeworm includes intermediate and dead-end hosts, ungulates and humans, as well as definitive hosts, the Canidae and Felidae. Disease caused by E. multilocularis, alveolar echinococcosis (AE) is more severe and also difficult to diagnose, especially in animals. Echinococcosis in livestock leads to morbidity and mortality, thereby facilitating economic losses at various levels. Reporting is mandatory, yet under-reporting is a common occurrence as is the failure to identify relevant geographical transmission foci in a timely manner, thus contributing to continuous tapeworm transmission and spread. As echinococcosis is a foodborne disease in animals and humans, the food industry, and particularly the meat industry, are key stakeholders in raising awareness, lobbying government authorities for control measures and improved diagnostics.M24707566
Antioksidativna i antidijabetična aktivnost etanolnih ekstrakata ploda kruške (Pyrus communis L.) sorte Kaluđerka iz Srbije
No full textProgram i izvodi saopštenja; 98 Book of abstracts 136M3
Comparative LC-MS Analysis and In Vitro Evaluation of Antioxidant, Antimicrobial, and Enzyme Inhibitory Properties of Ultrasound-Assisted and Soxhlet Extracts of Cachrys cristata DC
No full textThis study evaluated the extraction efficiency, phenolic composition, and bioactivity of Cachrys cristata using different methods. Ultrasound-assisted extraction (US) yielded higher extract amounts and phenolic contents, including flavonoids and flavonols, compared to Soxhlet extraction (S). While US 70% ethanol gave the highest extract yield, the US methanol (MeOH) extract contained the highest total phenolic content (105.47 mg gallic acid equivalents/g dry extract) and was selected for LC-MS profiling. Seventeen compounds were identified, with gentisic acid (39.03/50.73 mg/L), ferulic acid (27.00/25.68 mg/L), and rutin (13.28/11.91 mg/L) as dominant in Soxhlet and US extracts, respectively. The US MeOH extract showed strong antioxidant activity in DPPH and ABTS assays and eightfold higher anti-tyrosinase activity than kojic acid, while no acetylcholinesterase inhibition was observed. The hexane extract exhibited potent antibacterial effects against Staphylococcus aureus, Enterococcus faecalis, and Listeria monocytogenes, inhibited biofilm formation and pyocyanin in Pseudomonas aeruginosa, and had limited antifungal activity. It also strongly inhibited bovine serum albumin denaturation (88.88% vs. 95.60% for diclofenac). For antidiabetic potential, the US methylene chloride extract inhibited α-amylase better than acarbose (IC50 0.267 vs. 0.832 mg/mL) and moderately reduced α-glucosidase activity. These results provide novel insights into the phenolic profile and multifunctional bioactivity of C. cristata extracts.M222,500e0191
