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The relationship between the organization image which parents have and the school trust : An analysis which utilized individual and organization level data
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Attempt of Musical Expression Activity that Connects University, Attached School, and Regional Society
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A study on the instructional design promoting reorganization of knowledge : Reconsideration of the learning process symbolized `acquirement・application・inquiry'
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School Fee Problems in Prussian Elementary School in the Second Half of 19th Century
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Consumer's response to organic agricultural products and the production behavior of organic farmers: a questionnaire analysis
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Development of Perovskite-type Oxide Cathode for Proton-conducting SOFC
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Severe abnormalities in the reproductive organs of mice caused by chemical substances contained in heavy oil
Get PDFIt is well known that heavy oil pollution results in various negative impacts on the marine environment. Although there is a low possibility of direct exposure to heavy oil, the chemical substances contained in heavy oil may be released into the environment and accumulated by marine organisms which in turn can be taken by humans via the food chain. In this study, we examined the biological risk of heavy oil extract using the common mouse, whose genetic backgrounds and immune system are well known and relatively homologous to humans. Water-soluble fraction (WSF) was extracted from heavy oil with water and the extract orally administrated to female or male mice for 7 days. In the WSF administrated group, cystoma-like formation was observed in the ovary in approximately 80% of female mice. On the other hand, we found that the prostate gland size in male mice was markedly reduced in comparison with male control mice. Continuous administration of WSF for 28 days resulted in continued hypertrophy of the cystoma around the ovary and atrophy in the prostate gland. In addition, it was revealed that chemical substances within WSF have estrogenic activity. A major component of heavy oil, polycyclic aromatic hydrocarbons (PAHs), is known to present estrogenic activity. It is likely that the cystoma-like formation in female mice and atrophy of prostate gland in male resulted of estrogenic substances present in the WSF which might be the PAHs.journal articl