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Studies in the Falls Efficacy Scale-International for patients with cervical compressive myelopathy: Reliability, validity, and minimum clinically important difference
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Intravenous Injection of iPS Cell-Derived Endothelial Progenitor Cells Prevents Miscarriage by Releasing Pro-Angiogenic Factors in a Mouse Model of Recurrent Spontaneous Abortion
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Renoprotective Effects of Chymase Inhibition on Cisplatin-Induced Nephrotoxicity in Mice
Get PDFAlthough cisplatin is a useful antitumor drug, its nephrotoxicity is a critical limiting factor for this chemotherapy. The present study examined if mast cell-derived chymase might contribute to this pathology, through analysis of the pattern of chymase expression, as well as the effects of chymase inhibition, in a mouse cisplatin-induced nephrotoxicity model. We found that mast cells positive for the chymase, murine mast cell protease-4 (MMCP-4), and MMCP-4 mRNA expression in kidney tissues increased largely during the acute phase after cisplatin injection.
Increase in serum creatinine and blood urea nitrogen, as well as histopathological changes such as renal tubular enlargement, were also observed in cisplatin-injected mice. Only half of the cisplatin-injected mice survived during the 6-day observation period. mRNA expression of reactive oxygen species-related factors, as well as inflammationrelated factors, such as NOX2 and TNF-α, were all significantly increased in the acute phase after cisplatin injection. On the other hand, reduction in mast cell-derived chymase expression, along with improvement in renal function, histopathological changes, and survival rates, were observed in cisplatin-induced nephrotoxic mice treated with a chymase-specific inhibitor, suggesting that chymase plays an important role in cisplatin-induced nephrotoxicity in mice.departmental bulletin pape
Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells
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Biomarkers for Monitoring of Changes in Disease Activity in Ulcerative Colitis
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Plantar Pressure Distribution Before and After Surgery for Lesser Metatarsophalangeal Joint Dislocation With Hallux Valgus
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Development and Evaluation of a Program to Promote Self-management of Blood Glucose and Side Effect in Patients with Type 2 Diabetes Undergoing Chemotherapy for Cancer
Get PDFObjective: To develop a program to promote self-management of blood glucose and side effect in patients with type
2 diabetes undergoing chemotherapy for cancer and evaluate its validity and clinical applicability.
Methods: The program was developed based on the results from a literature review on blood glucose fluctuations
and side effect during chemotherapy in patients with diabetes and an empirical study in patients with type 2 diabetes
who were diagnosed with cancer and receiving chemotherapy. A total of 10 physicians and nurses who were
engaged in treatment of patients with diabetes undergoing chemotherapy participated in the study. A questionnaire
survey and an interview survey were conducted to evaluate the program developed.
Results: Regarding the program validity, the participants’ responses were generally favorable, while they suggested
some points for improvement, including partial revisions and additions to expressions and reconsideration of
information providers. As for the clinical applicability of the program, most participants considered that the program
can be used clinically for nurses.
Conclusion: The program was generally confirmed to be valid and clinical applicable. Moving forward, the
program requires further refinement and verification of its effectiveness in interventional studies.departmental bulletin pape