Osaka Medical and Pharmaceutical University Repository
Not a member yet
736 research outputs found
Sort by
Short communication: Distribution of phospholipids in parotid cancer by matrixassisted laser desorption/ionization imaging mass spectrometry
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi
Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi
Facial nerve course in the temporal bone: Anatomical relationship between the tympanic and mastoid portions for safe ear surgery
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi
Examination on factors affecting symptom change after drug withdrawal in patients with mild erosive gastroesophageal reflux disease undergoing symptom-controlled maintenance therapy with acid-secretion inhibition drugs
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi
Optimization of radiation therapy in bladder preservation therapy for patients with clinical stage T2N0M0 bladder cancer
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi
Intravenous Injection of iPS Cell-Derived Endothelial Progenitor Cells Prevents Miscarriage by Releasing Pro-Angiogenic Factors in a Mouse Model of Recurrent Spontaneous Abortion
Get PDFInsufficient production of cytokines and fluid factors involved in angiogenesis during early pregnancy causes
abortion due to placental dysplasia. Endothelial progenitor cells (EPCs) are immature endothelial cells that play important roles in vascular repair and neovascularization. In this study, we investigated whether human induced pluripotent stem cell-derived EPCs (hiPS-EPCs) could improve abortion rates in a mouse model of recurrent spontaneous
miscarriage. After the differentiation induction of hiPSCs, CD31/CD34 double-positive cells increased and showed the
presence of tube-like structures, confirming successful differentiation into hiPSEPCs. Intravenous transplantation of
hiPS-EPCs significantly reduced abortion rates in the mouse model. To elucidate the mechanism by which miscarriages were ameliorated, we investigated whether the cells were preserved in the embryos. We differentiated GFP-labeled
iPSCs into EPCs (GFP-EPCs), and intravenously injected them into the model mouse. Whole-mount immunostaining
analysis showed the presence of injected cells expressing GFP in the uterine vasculature adjacent to the embryos from
mice injected with GFP-EPCs. Furthermore, the gene expression of fluid factors such as VEGF and PlGF was increased
in the placentas of mice implanted with hiPSEPCs. These data indicate that hiPSEPC transplantation therapy may
reduce miscarriage via transplanted cells that remain in the uterine vasculature and secrete pro-angiogenic factors.departmental bulletin pape
Treatment Interventions in Three Adolescent Female Patients with Eating Problems Due to Dysfunctional Family Relationships
Get PDFEating problems, often seen in girls in mid-to-late adolescence, have an unknown etiology. The family backgrounds
of patients are diverse, and previous studies have reported an intrusive, hostile, and negative attitude toward the patients
with eating disorders by their family members. In this case series, we report about three adolescent female patients
with eating disorders due to dysfunctional family relationships, particularly mother-child relationships. In case 1, the
mother crossed generational boundaries and the roles of mother and child were reversed. In case 2, the mother was
over-involved with the child and the mother-child relationship was in an enmeshed state. In these two cases, therapeutic intervention was aimed at adjusting the family system based on the assumption of family dysfunction. However, in
case 3, maltreatment by the mother was observed, which directly affected the eating disorder. In family therapy, the
entire family is considered as the target of intervention, rather than assuming a single cause. However, focusing solely
on this may overlook ongoing maltreatment, as in case 3. To avoid overlooking such situations, it is necessary to listen
to both the patient and the family in the consultation setting and to tailor interventions to each family member without
preconceptions.departmental bulletin pape
Surgical Experience Disparity Between Male and Female Surgeons in Japan
Get PDF大阪医科薬科大学博士（医学）2022doctoral thesi