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Structural analysis of Spi-B DNA-binding Ets domain recognizing 5′-AGAA-3′ and 5′-GGAA-3′ sequences
No full textPlasmacytoid dendritic cells produce large amounts of type-I interferon (IFN–I) upon sensing nucleic acid components of pathogens by Toll-like receptors (TLR7 and TLR9). The transcription factor Spi-B has the DNA-binding Ets domain, and transactivates the Ifna4 promoter co-operatively with IFN regulatory factor-7 (IRF-7) for TLR7/TLR9-induced IFN-I production. Spi-B associates with IRF-7, and activates transcription by binding to the 5′-AGAA-3′ sequence, being different from 5′-GGAA-3′, known as the Ets domain recognition sequence. To understand the molecular mechanism for the co-operative transactivation of the Ifna4 promoter by Spi-B and IRF-7, we performed X-ray structural determination of the Spi-B Ets domain in complex with target DNAs, including 5′-AGAA-3′ and 5′-GGAA-3′ sequences. Furthermore, we conducted a modeling study of the complex of the Spi-B and IRF-7 with Ifna4 promoter DNA. X-ray structures showed that the binding of the Spi-B Ets domain induces a kink in DNA at the recognition sequence, and a more kinked DNA structure was observed in 5′-AGAA-3′ than 5′-GGAA-3’. A modeling study showed that the Spi-B-induced kinked DNA structure in 5′-AGAA-3′ is favorable for Spi-B and IRF-7 to approach each other for association on DNA.journal articl
Evaluation of Fascia Thickness of the Thigh and Gluteal Areas- An Anatomical Study
Full text link香川大学Kagawa University博士（医学）doctoral thesi
Endoscopic findings among healthy adults with asymptomatic norovirus infection in Japan: A single-center cross-sectional study
No full textIntroduction
Norovirus infection, a major cause of acute viral gastroenteritis, is commonly reported during the winter season. Norovirus invades the upper intestinal tract, causing inflammation. In severe cases, endoscopic findings and complications, including duodenal perforation, have been reported. However endoscopic findings in patients with asymptomatic infections have rarely been reported. Therefore, this study aimed to investigate the upper endoscopic findings of patients with asymptomatic norovirus infection.Methods
Healthy adults (aged ≥18 years) who participated in voluntary health examinations between February 2017 and January 2018 were recruited twice a week. Only the individuals who had undergone esophagogastroduodenoscopy (EGD) were included. The primary outcome measure was the presence of any gross findings of EGD.Results
The norovirus genogroup I (GI)-positive group had more duodenal scarring than the norovirus negative group (16.3 % vs 5.9 %, respectively). After adjustment for age category, sex, and alcohol consumption status, duodenal ulcer scarring exhibited a significant association with GI-positive status (adjusted odds ratio: 3.11; 95 % confidence interval: 1.42–6.82; p = 0.005, Bonferroni-corrected, p = 0.015).Conclusions
Healthy adults with asymptomatic norovirus (GI-positive) infection showed predominantly more duodenal ulcer scarring than the norovirus-negative group on EGD.journal articl
New Perspectives and Roles of International Exchange through Linguistic Analysis
Full text link国際的な開発目標であるミレニアム開発目標（MDGs）から持続可能な開発目標（SDGs）への移行において、「福祉」が新たに重要視されている。文部科学省の報告では、日本の動物福祉に関する議論は国際的な基準と比較して遅れており、国際的な活動や市民の支持も不足していることが明らかになった。特に日本では、動物福祉の概念の受容が遅れ、社会全体の意識改革が求められている。筆者は、本報告に先駆けた取り組みとして香川大学博物館では、産業遺産である乳牛の鋳型標本に注目し、動物福祉の重要性を再認識する展示を行った。そのうえで、香川大学で実施された国際交流活動に参加し、筆者が在籍中に報告した取り組みや学会活動、修士論文の作成時に引用した文字データに注目し、言語分析技術（テキストマイニング）による分析を行ったところ、動物福祉に関連する語彙の中で「ウェルフェア」を重要視した活動であったことが明確となった。本報告では、国際共同研究や国際シンポジウムへ関わる中で、動物福祉問題についての課題抽出法や国際交流活動を俯瞰する為、テキストマイニング手法を用いたデータ分析について考察し、本学で実施された国際交流活動がどのように動物福祉の理解増進に寄与できたものであるか、今後の国際交流の在り方や方向性に情報提供を促す解析結果を提供するものである。departmental bulletin pape
The 3rd Trilateral Symposium on Sustainability”-Strategies for Climate Action and Mitigation of Climate Change Impacts
Full text linkThe 3rd Trilateral Symposium on Sustainability: Strategies for Climate Action and Mitigation of Climate Change Impacts was successfully held from August 27 to August 29, 2024, at Kantary Hills Hotel, Chiang Mai, Thailand. This event was hosted by Chiang Mai University （CMU） in collaboration with Kagawa University （KU） and National Chiayi University （NCYU）, Taiwan. The symposium provided a platform for students, researchers, and university members from the three institutions to share their latest research and educational activities while fostering stronger academic collaboration.
Representing KU, President Prof. Natsuo Ueda, along with Vice Presidents, 37 faculty and staff members, and 31 students, actively participated in the symposium.departmental bulletin pape
Science and Technology Session
Full text linkThe science and technology session was held at the Science and Technology Park （STeP）, Chiang Mai University, on August 28th. Participants from the three universities - Cheng Mai University （CMU）, National Chai Yu University （NCYU） and Kagawa University （KU） - engaged in lively discussions, making the event highly successful. This, in turn, increased anticipation for the further advancement of collaborative research activities in preparation for the upcoming symposium.departmental bulletin pape