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Specific Patterns in Correlations of Super-Short Tandem Repeats (SSTRs) with G+C Content, Genic and Intergenic Regions, and Retrotransposons on All Human Chromosomes
No full textThe specific characteristics of k-mer words (2 ≤ k ≤ 11) regarding genomic distribution and evolutionary conservation were recently found. Among them are, in high abundance, words with a tandem repeat structure (repeat unit length of 1 bp to 3 bp). Furthermore, there seems to be a class of extremely short tandem repeats (≤12 bp), so far overlooked, that are non-random-distributed and, therefore, may play a crucial role in the functioning of the genome. In the following article, the positional distributions of these motifs we call super-short tandem repeats (SSTRs) were compared to other functional elements, like genes and retrotransposons. We found length- and sequence-dependent correlations between the local SSTR density and G+C content, and also between the density of SSTRs and genes, as well as correlations with retrotransposon density. In addition to many general interesting relations, we found that SINE Alu has a strong influence on the local SSTR density. Moreover, the observed connection of SSTR patterns to pseudogenes and -exons might imply a special role of SSTRs in gene expression. In summary, our findings support the idea of a special role and the functional relevance of SSTRs in the genome
Evaluation of a Cut Interruption Algorithm for Laser Cutting Steel and Aluminum with a High-Speed Camera
No full textWe report on a monitoring system based on a high-speed camera for fiber laser fusion cutting. The monitoring system is used without an external illumination retrofit on a conventional cutting head, with the optical path aligned coaxially to the incident laser, permitting a direct, spatially, and temporally resolved detection of the melt pool area in the cut kerf from the top view. The dependence of the melt pool area on laser processing parameters such as laser power and feed rate are thus evaluated for stainless steel, zinc-coated steel, and aluminum, respectively. The signal characteristics of the images captured from the melt pool are examined in the visible spectral range of the emitted secondary thermal radiation from the process zone. An ad hoc developed image processing algorithm analyzes the spectral and geometric information of the melt pool from high-speed camera images and distinguishes between complete and incomplete cuts
3D printed biosensor for continuous glucose measurement in cell cultures
No full textA novel 3D-printed glucose sensor is presented for cell culture application. Glucose sensing was performed using a fluorescence resonance energy transfer (FRET)-based assay principle based on ConA and dextran. Both molecules are encapsulated in alginate microspheres and embedded in the UV-curable, stable hydrogel polyvinyl alcohol (PVA). The rheology of the formulation was adapted to obtain good properties for an extrusion-based printing process. The printed sensor structures were tested for their ability to detect glucose in vitro. A proportional increase in fluorescence intensity was observed in a concentration range of 0 - 2 g/L glucose. Tests with HEK cell cultures also showed good cell compatibility and excellent adhesion properties on plasma-treated Petri dishes. The printed sensors were able to detect the glucose decay associated with the metabolic activities of the fast-growing HEK cells in the cell culture medium over ten days. The proof-of-principle study shows that metabolic processes in cell cultures can be monitored with the new printed sensor using a standard fluorescence wide-field microscope
Diagnosis of autism spectrum disorder based on functional brain networks and machine learning
No full textAutism is a multifaceted neurodevelopmental condition whose accurate diagnosis may be challenging because the associated symptoms and severity vary considerably. The wrong diagnosis can affect families and the educational system, raising the risk of depression, eating disorders, and self-harm. Recently, many works have proposed new methods for the diagnosis of autism based on machine learning and brain data. However, these works focus on only one pairwise statistical metric, ignoring the brain network organization. In this paper, we propose a method for the automatic diagnosis of autism based on functional brain imaging data recorded from 500 subjects, where 242 present autism spectrum disorder considering the regions of interest throughout Bootstrap Analysis of Stable Cluster map. Our method can distinguish the control group from autism spectrum disorder patients with high accuracy. Indeed the best performance provides an AUC near 1.0, which is higher than that found in the literature. We verify that the left ventral posterior cingulate cortex region is less connected to an area in the cerebellum of patients with this neurodevelopment disorder, which agrees with previous studies. The functional brain networks of autism spectrum disorder patients show more segregation, less distribution of information across the network, and less connectivity compared to the control cases. Our workflow provides medical interpretability and can be used on other fMRI and EEG data, including small data sets
Space Telescopes based on Satellite Tandem Flights
No full textDue to the recent progress in satellite control engineering, tandem flight arrangements of mini-satellites are currently in discussion and
under consideration for future space missions. CubeSat technologies offer an interesting possibility for space-born telescope payloads
based on this approach. In such a scenario, two small satellites will fly at a constant distance of a few meters up to 100 meters. Thereby,
the front satellite will carry the telescope optics and the second satellite the detector system. Related formation flight requirements were
addressed in the NetSat-Mission, composed of four 3U-CubeSats, launched 2020. Space technology challenges concern in particular orbit
control by an appropriate propulsion system as well as precision attitude pointing towards the joint target, and could be transferred from the
NetSat-mission to the proposed Tandem Mission. This will allow space-based telescopes with a long focal length even placed on board of
small or miniature CubeSat-type satellites. Cost effective Kirkpatrick-Baez type X-ray telescopes represent an important application here as
they have longer focal lengths compared to previous astronomical observatories using Wolter I type X-ray mirrors.Poste
AdLer - Adaptive digitale Lernräume: Autorentool und 3D-Lernumgebung
No full textDie fortschreitende Digitalisierung im Bildungssektor ist gerade für die Berufliche Weiterbildung von zentraler Bedeutung. Bereits seit längerer Zeit sind in diesem Kontext zeit- und ortsunabhängige Lehr-Lern-Formate sehr wichtig. Allerdings bietet digitales Lernen auch großes Potential hinsichtlich dem Thema Motivationsförderung. Serious Games stellen ein vielversprechendes Beispiel von Game-based Learning (GBL) dar, um die Lernmotivation zu adressieren. Hierbei geht es darum, Mechaniken (digitaler) Spiele zu verwenden, um einen Wissenserwerb zu ermöglichen, der zeitgleich motivierend gestaltet ist.
Das AdLer-Projekt hat zum Ziel ein frei verfügbares Instrument zu entwickeln, mit welchem Lehrende virtuelle 3D-Lernumgebungen erstellen und in ihrer Lehre in unterschiedlichen Formen einsetzen können. Mit Hilfe eines Autorentools werden Lehrende bei der Konzeption und Erstellung von 3D-Lernumgebungen unterstützt. Dadurch können Lehrende auf schnellem und einfachem Weg eigene digitale 3D-Lernumgebungen erstellen sowie nach ihren individuellen Vorstellungen hinsichtlich der eigenen Lernszenarien konfigurieren.
In der 3D-Lernumgebung können Lernende nach den Prinzipien des GBL erkundungsorientiert und interaktiv lernen. Dazu können Lernende mit einem virtuellen Avatar die AdLer-3D-Lernumgebung betreten und verschiedene Handlungsmöglichkeiten wahrnehmen. Sie können sich frei in dieser Lernumgebung bewegen und unterschiedliche Lernangebote (z.B. die Bearbeitung von Lernelementen, wie H5P, Text und Video) durchführen.
Im geplanten Poster-Pitch wird eine aktuelle Version der Software AdLer präsentiert und steht für die Konferenzteilnehmer zum Ausprobieren bereit.Poste
Testing of lobster-eye type telescopes with X-rays and visible light
No full textReflective coatings for astronomical X-ray optics were developed at the “Aschaffenburg Competence Center for Astronomical and Space Instrumentation” (ACCASI) since several years. As part of a Bavarian-Czech cooperation between the Technical University of Aschaffenburg and the Czech Technical University of Prague, now two mechanically identical telescopes were built. One telescope optic was equipped with conventional gold-coated mirrors, manufactured by the Czech project partners. The 34 X-ray mirrors of the second telescope use an innovative coating system made of chromium and iridium, which was applied at the Aschaffenburg coating laboratory. Both telescopes are designed according to the bionic principle of a reflecting lobster eye. The optics works with two consecutive reflections on mutually perpendicular mirror surfaces. This enables a large field of view with many square degrees in diameter, which, however, comes at the price of a reduced angular resolution. An extensive X-ray characterization of these telescopes was carried out at the PANTER test facility of MPE, which simulates parallel starlight incident on the telescopes. The telescopes have an angular resolution of about 4 arc minutes in X-rays and a focal length of about 2 meters. Furthermore, the used X-ray mirrors reflect and focus visible light as well and this functionality in the optical regime was checked in laboratory tests. Now another test campaign was done to examine the telescope resolution for real objects of the visible sky and the imaging properties for star constellations. Such functional tests by observing astronomical objects of the visible sky may simplify and accelerate the development of X-ray telescopes for satellite applications
Evaluation of an ultrashort pulsed laser robot system for flexible and large-area micromachining
No full textWe report for the first time on the realization, characterization and application of an ultrashort pulsed laser robot system for flexible and large-area 2D and 3D laser micromachining with 6 articulated axes. To characterize the dynamic positioning of the laser beam during and after axes movement, CMOS image sensors were integrated into the beam path. A method introduced for the alignment of the optical axes allows a reduction of the deviations in laser beam positioning to less than 141.8 ± 92.9 μm within a 110° rotation range of axis 4. In addition, a high laser beam positioning repeatability of less than 102.2 μm is demonstrated over a total period of 14 h for a movement of axis 5 within a range of 0° to 90°. Initial laser cutting, laser structuring and laser marking applications on automotive dashboards and glass substrates are presented for flexible and large area 2D and 3D manufacturing. By applying a special laser cutting strategy for processing AF 32 eco thin glass, high cutting quality is achieved with a taper of up to 96.3% without the generation of cracks, demonstrating the innovative potential of the high-precision laser robot system. Nonetheless, different identified inherent influences of each axis 1–5 during robot axis movement demand for an innovative beam stabilization concept to achieve high precision in laser beam positioning