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Photoneutron reactions on gold in the giant dipole resonance region: Reaction cross sections and average kinetic energies of (γ, xn) photoneutrons
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Mindful eating is associated with a better diet quality in the NutriNet-Santé study
No full textBackground: Mindful eating (ME) is a promising approach for promoting healthy eating. Although an association between ME and healthier eating habits has been indicated in the literature, data remain limited. The aim of this cross-sectional study was to investigate the association between ME and several nutritional indicators, including overall diet quality, consumption of ultra-processed foods (UPF), organic foods, food groups, and intake of energy and nutrients in a large population sample. Methods: In 2023, 13,759 participants of the NutriNet-Santé cohort study completed the Mind-Eat Scale, assessing total ME (range: 1–5), and its six sub-dimensions, and at least three 24-h dietary records. Multivariable linear regressions were performed to analyze the association between ME (independent variable) and various indices reflecting the nutritional quality of the diet: two scores reflecting the adherence to the French dietary guidelines (sPNNS-GS2) and the Mediterranean diet (MEDI-LITE score), the consumption of UPF (using the NOVA classification), organic foods and food groups, and energy and nutrient intake (dependent variables), adjusted for socio-demographic and lifestyle characteristics. Results: ME was positively associated with French dietary guideline (β = 0.33; 95%CI: 0.30, 0.45) and Mediterranean diet (β = 0.37; 95%CI: 0.30, 0.45) scores and with organic food consumption (β = 9.72; 95%CI: 8.84, 10.60). Furthermore, ME was negatively associated with energy intake (β = −36.79; 95%CI: 50.92, −22.67) and UPF consumption (β = −1.55; 95%CI: 1.81, −1.29). ME was also associated with the intake of several food groups and nutrients. Conclusion: Overall, ME was associated with a healthier diet. These results suggest that ME could be an interesting lever for promoting healthy eating habits. Further studies are required to better understand the relationships between ME, dietary intake, and health, particularly through the use of longitudinal studies.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Cuando los servidores de los dioses se enredan: un análisis de la dinámica de fusión y fisión entre los especialistas rituales mexicas
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Evidence that Dmrta2 acts through repression of Pax6 in cortical patterning and identification of a mutation crucial for DNA recognition associated with microcephaly in human
No full textDmrta2 (also designated Dmrt5) is a transcriptional regulator expressed in cortical progenitors in a caudomedialhigh/rostrolaterallow gradient with important roles at different steps of cortical development. Dmrta2 has been suggested to act in cortex development mainly by differential suppression of Pax6 and other homeobox transcription factors such as the ventral telencephalic regulator Gsx2, which remains to be fully demonstrated. Here we have addressed the epistatic relation between Pax6 and Dmrta2 by comparing phenotypes in mutant embryos or embryos overexpressing both genes in various allelic combinations. We show that Dmrta2 cooperates with Pax6 in the maintenance of cortical identity in dorsal telencephalic progenitors and that it acts as a transcriptional repressor of Pax6 to control cortical patterning. Mechanistically, we show that in P19 cells, Dmrta2 acts as a DNA-binding dependent repressor on the Pax6 E60 enhancer and that a point mutation that affects its DNA binding properties identified in a consanguineous family leads to agenesis of the corpus callosum, pachygyria, and the absence of the cingulate gyrus. Finally, we provide evidence that Dmrta2 binds components of the NuRD repressor complex and interacts with zinc finger proteins such as Zfp423. Together, our results highlight the importance and conserved function of Dmrta2 in cortical development and provide novel insights into its mechanism of action.info:eu-repo/semantics/inPres
Psychological insights on the fans' boycott of the 2022 FIFA World Cup
No full textThe 2022 FIFA World Cup in Qatar has been criticizedfor numerous social, political, and environmental issues.While an important call to boycott the tournamentspread worldwide, research has yet to document themotives underlying a boycott of such a mega sportingevent. We investigated fans' intentions to boycott the 2022FIFA World Cup in four countries of the Francophonieengaged in the World Cup (N = 1635). We found that beinghighly identified with the team and enjoying football foraesthetic pleasures predicted rejection of the boycott,while the most robust predictor of boycott intentionswas a concern for environmental issues. When assessingactual boycott behaviors among fans after the World Cup(N = 286), we found a significant decrease compared toboycott intentions. Importantly, this intention–behaviorgap was even more pronounced among politicized fanswith high awareness of social and environmental issueswho had initially planned to boycott the tournament.We discuss the paradox of calls to boycott mega sportingevents: Unlike other consumer products, these eventsoften have no alternatives, yet they are central to the socialidentity of sports fans. As a consequence, such a boycottmay be better explained by a low level of fandom ratherthan solely by strong political values, with remainingboycotters likely being those who had little interest in theevent from the outset.info:eu-repo/semantics/publishe
Early Use of Beneficial Biological Therapy on Younger Psoriasis Patients: Could a ‘Step‐Down’ Therapy Approach Be More Effective?
No full textABSTRACT Introduction Psoriasis is a chronic autoimmune skin disorder affecting roughly 2% of the population worldwide. This condition manifests variably due to individual phenotypes. As the number of therapies has increased, Belgium established its own registry. However, these treatments are often inaccessible due to reimbursement criteria. This study suggests that some groups of psoriasis patients (particularly younger patients) may selectively benefit from early treatment approaches with biological therapies. Material and Methods Patients diagnosed with psoriasis included in the Belgian Psoriasis Registry were included in the study. Collected data included socio‐demographic changes, lifestyle changes, psoriasis‐related characteristics, treatment specifics and treatment changes, and associated diseases. Results Two hundred and five patients were included. Patients were classified as responders if their Psoriasis Area Severity Index (PASI) score decreased by more than 75% between the initial visit and follow‐up (PASI75). 47% of patients achieved PASI75. In the short‐term, 50% of patients treated with biologic therapy, 30.5% on systemic conventional therapies, and 32.25% on topicals/phototherapy responded with PASI75. At long‐term follow‐up, an increase in response was observed in patients receiving biologic therapy, as well as in patients undergoing systemic conventional therapy (55.5%). Patients receiving treatment shortly after their first lesions' onset had better responses ( p value < 0.0001). Conclusion Intervening earlier with effective treatments improves outcomes, particularly in younger patients. Treatment algorithms should use a step‐down approach rather than a step‐up approach. This would enhance the number of responders and potentially reduce costs.info:eu-repo/semantics/publishe
Une configuration singulière autour du fantasme d’auto-engendrement :le cas d’Adèle.
No full textinfo:eu-repo/semantics/inPres
When RNA methylation meets DNA methylation: a mechanistic study
No full textThe intricate interplay between epigenetic modifications on DNA, histones, and RNA is crucial for gene expression regulation. While the connections between RNA methylation, particularly m6A, and histone modifications are gradually emerging, only hints of links between m6A and DNA methylation have been reported. This thesis focuses on the link between m6A RNA methylation, installed by the METTL3-METTL14 complex, and DNA methylation. It aims to explore the potential connection between RNA and DNA methylation, investigating whether direct interactions exist between their respective writer machineries and examining the biological relevance of this connection. The research is structured into two main sections: In the first section, we demonstrate that the METTL3-METTL14 RNA methyltransferase complex directly interacts with DNMT1, a key enzyme for DNA methylation, to recruit it to the chromatin. Through experiments in HeLa cells and mouse embryonic stem cells (mESCs), we reveal that this interaction promotes DNA methylation within gene bodies, independently of m6A modification. Genome-wide analyses further show a tendency for 5mC and RNA m6A to co-occur at shared gene targets. In the second section, we delve into the functional implication of the 5mC-m6A cooccurrence on gene expression and the biological relevance. We demonstrate that the two marks have an opposite role on the same target: gene body 5mC promotes transcription, while m6A reduces transcript stability. During mESC differentiation into embryoid bodies (EBs), this balance shifts. Specifically, as cells exit pluripotency, intragenic 5mC-levels increase while m6A decreases, leading to higher expression of key differentiation genes such as Eomes, Notch2, and Smad3. This study uncovers a novel layer of gene regulation, where m6A and gene body 5mC work in tandem to fine-tune gene expression. Both modifications are essential for stem cell differentiation, with their coordinated dynamics playing a pivotal role in the upregulation of developmental genes. These findings expand our understanding of how epigenetic and epitranscriptomic marks integrate to regulate gene expression in development and potentially other biological processes, providing new insights into the complex mechanisms of gene regulation.Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)info:eu-repo/semantics/nonPublishe
Football presidents: towards a typology of political cultures
No full textinfo:eu-repo/semantics/publishe