SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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The prevalence and correlates of selected skin diseases in a scheduled tribe community in rural Gadchiroli, Maharashtra
No full text“DEVELOPMENT OF HIGHLY FLUORESCENT NANOSYSTEMS FOR BIOMEDICAL SENSING, IMAGING AND THERAPEUTIC APPLICATIONS
No full textGeo-spatial analysis of routine data on malaria in Gadchiroli district of Maharashtra, India over a four-year period from 2016 to 2019
No full textPattern of usage of social media, digital screens and its association with physical activity among school going adolescents in Thiruvananthapuram city
No full textAssessment of quality of life and potential depression among individuals undergoing dialysis –a study in Palakkad district , Kerala
No full textGeneration of niche tuned antifibrotic fibroblasts and non-viral mediated endothelial commitment using adipose stem cells for dermal graft development
No full textCell‐based skin substitute generation has seen considerable development. Combining synthetic scaffolds with biomimetic fibrin does direct both exogenous and endogenous stem cell differentiation, addressing needs for reliable tissue engineering. However, lack of immediate vasculature within implantable grafts remains critical for its sustenance and integration. Multipotency, high proliferation potential, ability to release multiple growth factors (GFs), and autologous availability highlight the use of human adipose derived mesenchymal stem cells (hADMSCs) in tissue‐engineered dermal grafts (TEDG) construction. However, hADMSCs' insufficiency to independently establish angiogenesis within tissue constructs demands improvement of stem cell application for dermal graft survival. Approaches to harness microenvironmentally sensitive paracrine interactions could improve the angiogenic efficiency of hADMSCs within TEDG. This study conceptualized a fibrin‐based niche, to direct hADMSCs toward a nonfibrotic fibroblast commitment and incorporation of bioengineered hADMSCs, specifically releasing potent angiogenic factors within TEDG. Coexistence of tuned fibroblast and endothelial lineage committed cells contributed to well‐regulated extracellular matrix formation and prevascularization. Adequate cell proliferation; sustained transient release of angiogenic GFs till 20 days; directed dermal, endothelial, fibroblast, and vascular smooth muscle cell differentiation; and favored elastin and collagen deposition were achieved in vitro . In conclusion, specific niche composition and employment of bioengineered hADMSCs favor implantable TEDG construction
Community Preparedness among residents living in a chemical Accident-prone Industrial area in Ernakulam District
No full textVanadium pentoxide nanoplates: Synthesis, characterization and unveiling the intrinsic antibacterial activity
No full textThis study reports the synthesis and characterization of vanadium pentoxide nanoplates (VnNp) with the unique shape. Electron microscopy identified morphological alterations on the bacterial surface of representative Gram-positive, Staphylococcus aureus and Gram-negative, Escherichia coli upon VnNp treatment. In addition, Raman spectral mapping also elucidated changes in the bio-molecular signals from these bacteria. Further, the study proved reactive oxygen species (ROS) generation in E. coli biofilms. Overall, the results envision the possible use of VnNp as a potential surface coating agent to impart antibacterial activity