SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy
No full textTarget-specific reactive oxygen species (ROS)-based cancer treatments with high therapeutic efficacy and minimal side effects have been identified recently as a potentially effective cancer management strategy. Herein, we report the fabrication of a targeted nanotheranostic agent built on an iron oxide nanoparticle-decorated graphene–gold hybrid [plasmonic magnetic nanoprobe (PMNP)] for self-guided magnetic resonance (MR)/surface-enhanced Raman scattering imaging and photothermal therapy (PTT)/chemodynamic therapy (CDT). In the presence of glutathione, which is abundant in the tumor environment, the iron oxide nanoparticles undergo in situ reduction, which in turn generates hydroxyl radicals via a Fenton reaction to realize targeted destruction of tumor cells. Moreover, the localized production of heat benefited from the near-infrared absorption of the PMNP accelerates the intratumoral ROS generation process, with a synergistic effect of CDT/PTT. Furthermore, the probe offers an accurate visualization of the intracellular localization of the material through SERS/MR dual imaging channels. In view of the advantages offered by the tumor-specific stimuli-responsive nature of the probe, the PMNP presents as an effective tool for cancer management
Exploring occupational health in the context ofprecarious work: a case study of workers in unorganized e-waste sector in the slums of bholakpur ward of hyderabad district
No full textPrevalence of risk factors for Non-communicable diseases Among tribal people in aralam Farm, kannur
No full textStudy of change in n-terminal pro-brain natriuretic peptide levels in patients undergoing percutaneous balloon mitral valvuloplasty and correlation with echocardiographic and hemodynamic parameters
No full textQuantitative estimation of regional brain iron deposition - a potential biomarker for Parkinson's Disease and other neurodegenerative conditions causing a typical Parkinsonism
No full textCascade of immune mechanism and consequences of inflammatory disorders
No full textInflammatory responses arise as an outcome of tissues or organs exposure towards harmful stimuli like injury, toxic chemicals or pathogenic microorganism. It is a complex cascade of immune mechanism to overcome from tissue injury and to initiate the healing process by recruiting various immune cells, chemical mediators such as the vasoactive peptides and amines, pro-inflammatory cytokines, eicosanoids and acute-phase proteins to prevent tissue damage and ultimately complete restoration of the tissue function. The cytokines exhibits a central function in communication between the cells, inflammatory response initiation, amplification and their regulation. This review covers the importance of inflammatory responses; the significance of cytokines in inflammation and numerous inflammatory disorders/ailments due to the abrupt expression of cytokines and the hyper-inflammatory response or cytokine storm associated with poor prognosis in COVID-19 pandemic. Also highlighting the importance of naturally derived anti-inflammatory metabolites to overcome the side-effects of currently prevailing anti-inflammatory drugs
Determinants of physical activity among adults in kottayam district of kerala, india: a socio-ecological approach
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Profiling of physiotherapy facilities and consequence of covid-19 pandemic on physiotherapy practices in 2020 in odisha, india.
No full textMicrofluidic based human-on-a-chip: A revolutionary technology in scientific research
No full textBackground
Detrimental drug toxicity and failure in efficacy during clinical trials is one of the major hurdles faced by the pharmaceutical companies. Conventionally, preclinical safety evaluation is performed in 2D cell cultures and animal models. However, the response of a drug seen in laboratory animals and cells grown as monolayers differs from how cells inside a human body respond. This is due to the lack of multi-organ interaction in cell cultures and species specificity between animal and human.
Scope and approach
Recently, progress in organ-on-a-chip (OoC) including multi-organ-on-a-chip (MoC) platform offers fast and cost-effective alternative approach to screen drugs authentically. Advanced human-on-a-chip (HoC) consists of several human organs held together in a hierarchical and physiological pattern crafting an in vitro human model. HoC recapitulates the structural and functional integrity of human system and overcomes the limitations of traditional protocols and inaccessibility to human models.
Key findings
In HoC, cells are cultured in a sterile controlled environment that allows manipulation of physico-chemical factors, monitoring molecular and functional aspects in a more realistic environment. It also upgrades the knowledge on pharmacokinetics and pharmacodynamics of compounds. There is no doubt that HoC technology is a game changer that will revolutionize clinical research in the upcoming years. This review explains the evolution of OoC to HoC, their potential use and limitations. More emphasis has been given on the potential use of HoC in pharmacology.
Conclusions
Pharmaceutical companies, academic institutions and regulatory agencies should initiate a joint venture to launch and utilize the full potential of HoC technology as a next generation alternative to preclinical or disease modelling studies