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Dataset supporting 'Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial'
Get PDFThis dataset was collected as part of my PhD thesis 'An exploration of the prebiotic concept: from food matrix to mood state'. The aim of this study was to determine the effects of the prebiotic oligofructose and prebiotic candidate 2'fucosyllactose on microbial load and composition and mood state. This dataset contains the individual level participant bacterial load and composition, gastrointestinal sensation and bowel habit, and mood state data collected throughout the course of the five-week intervention, along with all original 16S rRNA sequencing reads
Data supporting 'Stigma predicts mental health secrecy, (non)/disclosure, and loneliness in young people with major depressive disorder (MDD) symptoms: results of a multi-wave analysis'
Get PDF***This dataset has been withdrawn: An updated version of the dataset is available at https://doi.org/10.17864/1947.001318***
Mental health stigma has lasting negative effects on young people with major depressive disorder (MDD). Prior research suggests that younger people are typically more prone to experiencing stigma. Past research has largely focused on adults and older people with mental health problems, and the impact of stigma on young people with MDD is less well understood. Furthermore, the impact of stigma and/or depression on young people and their secrecy, disclosure, and loneliness is unclear. This paucity of knowledge may undermine efforts to build informed interventions to help young people with depression reconnect and reduce loneliness and social isolation.
The aim of this research was to examine two alternative explanations for predicting social outcomes in young people with depression: namely, we explored whether it is depression symptoms directly or the stigma surrounding it that drives secrecy, non-disclosure, and loneliness observed in this population. This knowledge can be used to improve efforts to build informed interventions to help young people with depression reconnect and reduce loneliness and isolation.
This study provides new evidence of how stigma is an important driving factor, rather than depression, for multiple mental health outcomes in young people. Interventions, such as treatment programs and public awareness campaigns via the UK NHS or government public health bodies, are recommended to directly reduce stigma
Supplementary materials for the thesis 'Investigating durable resistance to Phytophthora cactorum in strawberry and apple'
Get PDFDataset containing the supplementary material in support of the PhD thesis "Investigating durable resistance to Phytophthora cactorum in strawberry and apple". These include the details of individual genotypes, linkage maps, markers and QTL loci used and resulted from mapping experiments. They also include details of the RNA sequencing results from various experiments including sequencing and alignment quality, and differential expression analysis results. Also included are the results of gene set enrichment analysis performed on differentially expressed gene sets
A life history study of the factors that influence the acceptance or rejection of the Big Bang theory and theory of biological evolution among lifelong learners. 20 interview transcripts.
Get PDFThe nature of the problem to be studied is the continuing rejection of the Big Bang theory and the theory of biological evolution by a minority of lifelong learners despite the time that has elapsed since the original theories were proposed and their acceptance by the scientific community. Having examined various approaches, the researcher considered the appropriateness of a life history methodology. No other approach provided the methodology that was necessary to systematically study the factors from early childhood to late retirement that influence the acceptance or rejection of the Big Bang theory and biological evolution among life-long learners in a chronological data collection process. To select participants for this research, the researcher utilised purposive sampling to establish a correspondence between research question and sampling so that individuals who are relevant to the research question are interviewed. The researcher selected 10 purposive sampling individuals for this study, undertaking a total of 20 interviews, 2 interviews per individual. The life history approach can use structured, semi-structured and unstructured interviews as there is no lockstep approach, and for this study a semi-structured format of interviews was devised using a mixture of prompting open and closed questions, around the main issue of the study to reveal insight into the factors that influence the acceptance or rejection of the Big Bang theory and theory of biological evolution among lifelong learners. A two-stage interview procedure was devised. The research tools that enabled the study consisted of the interview venues, the raw data collection devices, and the qualitative data software. Subsequently any handwritten interviews notes, typed notes or recordings were transcribed to the computer software word processing package Microsoft Office 365. The ethical issues arising from the research were ones of informed consent, confidentiality, recording, quoting extracts and participant emotions. These ethical issues were firstly addressed by ensuring that informed consent was obtained before each interview. Confidentiality and quoting extracts were addressed by protective pseudonyms and anonymising place names, teachers, family members and groups. It was possible for the researcher to take notes, type, or record answers depending on the preference of the interviewee. The 20 interview notes typed answers or recordings were subsequently transcribed to the word processing package Microsoft Office 365. All interview data is held securely by Research Data Service, University of Reading. All ethical considerations were acknowledged and the guidelines of the University of Reading�s ethical procedures in research were followed at all times
Evaluating an early social communication intervention for young children with Down Syndrome: a feasibility study (ASCEND)
No full textThis feasibility study aims to estimate the parameters to inform a future randomised controlled trial to test whether an early social communication intervention is effective in improving language skills in young children with Down Syndrome. In a two-arm randomised controlled trial (RCT), with 1:1 randomisation stratified by trial site, children were allocated to receive either the intervention plus standard NHS speech and language therapy, or standard NHS speech and language therapy only.
In the intervention arm, parents/guardians received brief training videos on the parent-based intervention, a manual to follow with their child, a bag of toys and parent diaries. The intervention lasted 10 weeks.
Twenty children with Down Syndrome, aged between 11 and 36 months were recruited into the trial and 19 were randomised. The dataset contains the baseline, post-treatment and 6 month follow-up data from 9 participants receiving the intervention (in addition to standard NHS speech and language therapy) and 10 control participants receiving standard NHS speech and language therapy only
Functional and behavioural response data of the anthocorid Anthocoris nemoralis to Cacopsylla pyri, at different temperatures, Kent, UK
Get PDFThis dataset contains functional response data for the anthocorid Anthocoris nemoralis consuming pear sucker (Cacopsylla pyri) nymphs at three different temperatures (18, 21, and 23°C). The number of nymphs consumed after 24hrs were counted at 5 different prey densities (5,10,15,30 and 50 nymphs) to calculate a functional response.
The dataset also contains behavioural responses of the anthocorid Anthocoris nemoralis to pear sucker (Cacopsylla pyri) nymphs, eggs and no food as a control. The time spent demonstrating 6 different behaviours (feeding, moving, moving leaf, antennating, cleaning and stationary), was recorded over a 20-minute time period. The velocity, distance travelled, time spent in the centre and edge zones by the anthocorid were also recorded.
Finally, the dataset includes the temperature and relative humidity of the three controlled temperature cabinets, during the duration of the experiments. These were measured using an EasyLog USB datalogger at five minute intervals
Dataset supporting paper 'Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles'
Get PDFThis dataset includes all reports and summaries of raw data supporting the results presented in the paper "Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles". The objective of this paper is to investigate whether daily supplementation of participants at moderate risk of (cardiovascular diseases) CVDs with 1.8 g/d of fish oil-derived n-3 polyunsaturated fatty acids (PUFAs) altered the generation, composition and function of circulating and platelet-derived extracellular vesicles (EVs). Data about EVs parameters include: i. the numbers, and size of circulating total EVs and in vitro generated platelet-derived EVs (PDEVs) measured by Nanoparticle Tracking Analysis (NTA); ii. the numbers of EV subpopulations (i.e. phosphatidylserine-positive EVs (PS+EVs), PDEVs, endothelial-derived EVs (EDEVs)) and PS expression on PDEVs generated in vitro from platelets measured by flow cytometry (FCM); iii. the procoagulatory activity of circulating EVs (in vitro thrombogenic potential in activating tissue factor-dependent thrombin generation) measured by thrombin generation assay. The coagulatory behaviour of PDEVs generated in vitro from platelets measured by thrombin generation, clot formation, fibrinolysis and in vivo thrombus formation assays. Data about conventional cardiovascular risk markers include i. body mass index (BMI) measured by Tanita; ii. blood pressure measured by upper arm blood pressure monitor; iii. plasma lipid profile (i.e. triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and glucose concentrations measured by iLab. Data about thrombogenic markers include: i. plasma platelet aggregation measured by 96-well high-throughput aggregometry; ii. plasma thrombin generation measured by thrombin generation assay; iii. plasma clot growth and fibrinolysis measured by thrombodynamics analyzer
Data supporting 'Ultrahigh-throughput and low-volume analysis of intact proteins with LAP-MALDI MS'
No full textAs part of the PhD project 'Novel applications of liquid MALDI MS for the analysis of large biomolecules' funded by the University of Reading and Waters Corporation, the use of high-throughput analysis towards intact mid-sized proteins was investigated.
Raw and processed data for liquid atmospheric-pressure matrix-assisted laser desorption/ionisation (LAP-MALDI) mass spectrometry analysis of three mid-sized proteins at analysis rates of up to 20 samples/second are presented
Trash screen blockage detection using cameras and deep learning: code and dataset
No full textThis dataset provides access to the images and network weights produced during our research on trash screen detection, along with minimum working examples allowing to use the network weights on new trash screen camera images. The images come from 54 different cameras with open access feeds provided by the Environment Agency (http://eadevonwebcams.org.uk/), and were collected from January 2022 to January 2023. The images were manually annotated with a "clear" (if the trash screen looks clear), "blocked" (if the trash screen looks blocked) or "other" (if unsure) label. The network weights and minimum working examples allow to estimate labels of new trash screen images using three different methods: a classifier, a siamese network and an anomaly detection method
Dataset supporting 'Effects of food matrix on the prebiotic efficacy of inulin-type fructans: a randomised trial'
Get PDFThis dataset was collected as part of my PhD thesis 'An exploration of the prebiotic concept: from food matrix to mood state'. The aim of this study was to determine the effect of the food matrix on the prebiotic efficacy of inulin-type fructans. This dataset contains the individual level participant bacterial load and composition, gastrointestinal sensation and bowel habit data collected throughout the course of the ten-day intervention, along with all original 16S rRNA sequencing reads