The Bioscan
Not a member yet
3512 research outputs found
Sort by
Cognitive Emotion Regulation among Visually Impaired Young Adults: Insights from an Indian Context
Get PDFThis study examined cognitive emotion regulation strategies among visually impaired young adults, who face significant emotional and psychological challenges due to their disability. The aim was to investigate patterns of emotion regulation in the currently underexamined population of individuals with VI, as these are known to experience difficulties with emotion regulation compared to their sighted peers. Sixty-six visually impaired college students in the age of 20 to 30 years were assessed in a cross-sectional study using standard questionnaire for cognitive emotion regulation strategies in Lucknow. The study revealed a significant gender difference, with female scoring higher on maladaptive strategies like self-blame, catastrophizing, and blaming others. Differences in family type for only Positive Refocusing, significant differences emerged between joint and nuclear family types. The study underscores the need for targeted strategies to improve emotion regulation skills in young adults with VI, focusing on gender-specific patterns and leveraging family support
SELECTIVE CYTOTOXIC EFFECT OF ALLIUM ASCALONICUM ETHANOL EXTRACT AGAINST HEPG-2 CELLS VIA ROS-MEDIATED APOPTOSIS
Get PDFCancer remains a leading global health concern, necessitating the search for effective and less toxic therapeutic agents from natural sources. This study investigates the anticancer potential of ethanol extract of Allium ascalonicum (shallot) against human hepatocellular carcinoma (HepG-2) cells, with Vero cells used as a normal control. The cytotoxic effects were evaluated using the MTT assay, while DAPI and DCFDA staining were employed to detect apoptotic nuclear changes and reactive oxygen species (ROS) generation, respectively. The extract demonstrated significant, dose-dependent cytotoxicity in HepG-2 cells, with an IC50 value of 80 μg/mL, and showed minimal toxicity in Vero cells, indicating selectivity. DAPI staining revealed characteristic apoptotic nuclear condensation, and DCFDA results confirmed enhanced ROS production in treated cancer cells. These results suggest that Allium ascalonicum ethanol extract induces ROS-mediated apoptosis and may serve as a promising, selective anticancer agent for liver cancer therapy
Mini review of Phytosterols: Benefits, Mechanisms and Biomedical Applications
Get PDFPhytosterols, or plant sterols, are natural compounds with a chemical structure similar to cholesterol, enabling them to lower LDL cholesterol by inhibiting its absorption. This systematically examines the science of phytosterols, beginning with an exploration of their chemical structure, side-chain variations, and the specific types, including beta-sitosterol, campesterol, and stigmasterol. The analysis extends to a review of their primary sources, from natural plant-based foods to commercially fortified products and supplements. The document synthesizes current research on the health benefits, particularly the proven reduction of LDL cholesterol by 5-15% with a daily intake of 2 grams. It also addresses potential side effects, such as reduced absorption of fat-soluble vitamins, and concludes by validating phytosterols as a crucial component of a heart-healthy diet
The changing aspects of agriculture in the border area of Kolayat Tehsil
Get PDFThe development of agriculture started with the development of human civilization. As humans develop, the development of agriculture also changes accordingly. In the beginning, humans used to do traditional farming. Traditional farming was done with less resources but as technology developed, the form of agriculture also kept changing. At present, farmers get maximum production with less resources. Agriculture has got new momentum from the research being done in the present time, due to which it has moved towards commercial agriculture. Farmer's income has increased due to commercial agriculture. Kolayat tehsil located in the desert of Tha is currently moving from traditional farming to modern farming. Government schemes and technology have established new dimensions of agriculture in this area. The means of education, medicine and communication have increased due to the income from agriculture in this area
BRIDGES OF COMFORT: NURSE-LED INTERVENTIONS IN FEEDING AND MOTHERHOOD
Get PDFBackground:Feeding difficulties are more common in children with cerebral palsy and have an effect on growth, Nutritional state, general health, social interaction and behavior and developmental outcomes. Feeding practices and effective care for children with cerebral palsy are essential to avoid complication and reduce stress for the caregiver and the child. Nurse-led interventions, including education on positioning, Modified food texture, Modified feeding strategy and Swallowing exercises for managing these health risks and improving quality of life of the mothers and the children with cerebral palsy.Objectives: Assess the effectiveness of Nurse led intervention on feeding practices and explore the feeding experiences among mothers of children with Cerebral palsy.Materials and Methods:A mixed-method explanatory sequential design was utilized based on Health Belief Model. A total of 50 mothers of children with cerebral palsy were included in the study. Quantitative data were gathered through a validated Feeding/Swallowing Impact Survey Tool before and after nurse-led interventions, while qualitative insights were obtained through phenomenological interviews with five mothers. Statistical analyses and thematic analysis were conducted.Result:In the pretest, the feeding practices lies in the very high to high impact score. Following intervention, the Post test findings showed a significant reduction in mean feeding practices impact (from 75.53 to 42.31). Qualitative Thematic analysis revealed Feeding as an Emotional and Physical challenge, Impact on Family Dynamics, Adaptive Strategies and Resilience, Support System and Hospital experiences, including of 13 subthemes.Conclusion:Nurse-led interventions significantly improved feeding practices and reduced fear and anxiety and complications during feeding among mothers of children with cerebral palsy. Addressing physical challenges and enhancing family involvement, support services and accessible care services are crucial for betterment of quality of life of children and improving feeding practices among mothers
HOMOEOPATHIC MANAGEMENT OF AUTOIMMUNE DISEASES - A CASE SERIES ON PSORIASIS
Get PDFPsoriasis is an autoimmune skin disease characterized by T cell-mediated hyperproliferation of keratinocytes. It is a longterm dermatological disorder that can adversely influence both physical health and mental well-being. We observed eightpatients diagnosed with psoriasis who were managed with individualized Homoeopathic medicines selected on the basis oftheir characteristic presentations. Over the course of follow-up, all patients demonstrated steady clinical improvement. Longstanding lesions gradually became thinner, scaling was markedly reduced, and itching diminished significantly. Within a fewmonths, the overall condition of each patient had improved without any adverse reactions being reported.In addition to the relief of skin symptoms, patients described enhanced general well-being, better quality of sleep, and greaterconfidence in their social interactions
COMPARATIVE CYTOTOXIC AND ANTIPROLIFERATIVE EFFECTS OF ACTINIDIA DELICIOSA EXTRACTS ON HEPG2 HEPATOCELLULAR CARCINOMA CELLS
Get PDFHerbal medicines derived from natural sources are gaining attention for their potential therapeutic roles in cancer treatment. This study evaluates the anticancer activity of various solvent extracts of Actinidia deliciosa (kiwi fruit) against the human hepatocellular carcinoma (HepG-2) cell line using MTT assay. Five extracts—aqueous, chloroform, ethyl acetate, hexane, and methanol—were tested at concentrations ranging from 25 to 125 µg/mL. Among these, the methanol extract showed the most potent cytotoxic effect with an IC₅₀ value of 22.63 µg/mL after 48 hours. Cytomorphological analysis confirmed morphological changes in treated cells, indicating apoptosis. These results suggest that A. deliciosa, especially its methanol extract, holds promise as a potential natural anticancer agent
ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACT OF SEAWEED (ENTEROMORPHA INTESTINALIS) AGAINST JUICE-DERIVED PATHOGENS
Get PDFThis study investigates the in vitro antimicrobial efficacy of 90% methanolic extract of Enteromorpha intestinalis, a green seaweed species, against microorganisms isolated from fresh fruit juices. The isolates were characterized using 16S rRNA sequencing. Antimicrobial activity was assessed through disc diffusion and well diffusion assays against selected bacterial and fungal pathogens. Phytochemical analysis confirmed the presence of various bioactive compounds including alkaloids, flavonoids, phenols, tannins, steroids, and terpenoids. The methanolic extract exhibited moderate antifungal activity but lacked significant antibacterial properties. Thin Layer Chromatography (TLC) analysis revealed multiple bioactive compounds, and PCR was employed to verify molecular identity. The findings support the potential of E. intestinalis as a source of natural antifungal agents in food preservation and pharmaceutical applications
Scenario-Based and Simulation Learning in Adolescents' Health Education: A Scoping Review
Get PDFBackground:
Adolescents are at a critical stage for acquiring essential health knowledge and life-saving skills. However, traditional didactic approaches often fail to effectively build first aid competencies. Scenario-based learning (SBL) and simulation techniques offer interactive alternatives that promote practical skill development and knowledge retention.
Objective:
This systematic review aims to assess the effectiveness of scenario-based and simulation learning strategies in improving adolescents’ first aid knowledge, practical skills, and confidence.
Methods:
A systematic review was conducted using 55 peer-reviewed studies published between 2018 and 2023. Studies included school-aged adolescents (10–18 years) who received scenario-based or simulation-based first aid training. Data were extracted regarding intervention type, outcomes, and effectiveness, and a thematic analysis was performed
A Pragmatic Review of COVID-19 Management: Therapeutic Approaches, Challenges, and Recommendations
Get PDFThe coronavirus disease 2019 (COVID-19), caused by the novel RNA virus SARS-CoV-2, was declared a global
pandemic on 11 March 2020. Its rapid worldwide transmission highlighted the urgent need for effective clinical
management strategies. Patients with inflammatory and immunological disorders undergoing systemic immunotherapy
face an increased risk of infection and adverse outcomes. This review critically examines current therapeutic approaches,
including the use of steroids, remdesivir, oxygen therapy, and vaccination, alongside an assessment of unproven treatments
such as ivermectin and hydroxychloroquine. Emphasis is placed on pragmatic home-based care for mild to moderate cases
to reduce the burden on overstrained healthcare systems. Furthermore, challenges related to misinformation, resource
shortages, and inconsistent policy implementation are discussed. The findings suggest that systemic immunotherapy may
be continued in selected patients with careful monitoring, while broader strategies such as vaccination, early triage, and
community-level interventions remain central to effective pandemic control