The Bioscan
Not a member yet
3512 research outputs found
Sort by
EVALUATIONOFANTI-DIABETICACTIVITYOFFLAVONOID RICH FRACTION FROM METHANOLIC EXTRACT OF COCCINIAGRANDIS
Get PDFThe present investigation aimed to evaluate the extraction efficiency, phytochemical profile, chromatographicseparation,toxicity,andantidiabeticpotentialofthemethanolicextractanditsisolatedfractionsfromCocciniagrandisfruit.Themethanolicextractexhibitedasignificantlyhigheryield(18.16%)comparedtothepetroleumetherextract (1.56%), indicatingsuperior extractionof polar bioactive constituents. Phytochemical screening revealed the presence of alkaloids, phenolics,flavonoids, tannins,steroids, triterpenoids,andsaponins,whichwassupportedbyhightotalphenoliccontent(88.03mgGAE/g)and total flavonoid content (71.31mgQE/g). Column chromatographyyielded eight fractions, amongwhichFractionF2demonstratedthehighestflavonoidconcentration(138.37mgQE/g).AcutetoxicitystudiesconfirmedthatFractionF2wassafeupto2000mg/kg. Invivoantidiabeticevaluationinalloxan-induceddiabeticratsshowedthatF2significantlyimprovedbodyweight, reducedfastingbloodglucose levels, andrestoredlipidprofiles inadose-dependentmanner.TreatmentwithF2alsonormalized elevated biochemical markers such as SGOT, SGPT, creatinine, and urea, indicating hepatoprotective andnephroprotective effects. These therapeutic responses areattributed to the flavonoid-richnatureofF2,whichmayenhanceinsulinsensitivity,modulateglucosemetabolism,andattenuateoxidativestress.Thefindingsdemonstratethattheflavonoid-richFractionF2ofCocciniagrandisexhibitspotentantihyperglycemic,antihyperlipidemic,hepatoprotective, andnephroprotectiveactivities.ThestudyscientificallysupportsthetraditionaluseofCocciniagrandisindiabetesmanagementandhighlightsF2asapromisingnaturaltherapeuticcandidateformetabolicdisorders
ANALYTICAL STANDARDIZATION OF LASHUNA RASAYANA (ALLIUM SATIVUM): HPTLC-BASED PHYTOCHEMICAL ASSESSMENT AND PHYSICOCHEMICAL PROFILING
Get PDFLashuna (Allium sativum Linn.), commonly known as garlic, has been used safely since ancient times as both food and medicine. It is a rich source of diverse phytochemicals and is recognized for a wide spectrum of biological activities. Garlic contains several sulphur-bearing active constituents—principally thiosulfates—which are rapidly absorbed, metabolized, and largely responsible for its pungent aroma as well as many of its pharmacological effects. Traditionally, garlic has been employed for centuries in the management of various disorders, ranging from infectious diseases to metabolic imbalances.In Ayurveda, Lashuna is classified as Rasayana, an important group of drugs reputed to enhance health, vitality, immunity, and longevity. As a Rasayana, it is recommended both for disease prevention and the management of chronic systemic disorders. In contemporary times, garlic remains one of the most widely used natural remedies in the United States and Western Europe, particularly for reducing risk factors associated with cardiovascular diseases. Experimental and clinical investigations have validated its therapeutic potential across multiple systems including the cardiovascular, respiratory, genitourinary, gastrointestinal, hematopoietic, and integumentary systems. Garlic is consumed and prescribed in a wide variety of forms such as tablets, capsules, inhalations, beverages, alcoholic extracts, aqueous macerations, oil preparations, raw or roasted cloves, and cooked fractions.Analytical evaluations of Lashuna Rasayana using methanolic extracts have demonstrated a distinct HPTLC profile, including a prominent band at Rf 0.80 under both short- and long-wave UV. Densitometric scanning revealed a characteristic peak at Rf 0.28 ± 0.04, corresponding to the amino acid alanine, one of the 17 amino acids and 33 sulphur compounds known to be present in garlic. Physicochemical assessments—such as moisture content (2.25%), average capsule weight (578.2 mg), and disintegration time (14 minutes)—were found to be within acceptable limits, supporting the formulation’s quality and stability.Collectively, the classical significance, wide-ranging therapeutic potential, and modern analytical validation emphasize the importance of Lashuna Rasayana as a standardized Ayurvedic Rasayana. The established chromatographic fingerprint and compliant quality-control parameters provide a reproducible reference model for future research, formulation development, and regulatory standardization
Effect of an Eight-Week Preksha Meditation Programme on Symptom Severity and Quality of Life in Patients with Irritable Bowel Syndrome
Get PDFBackground: Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder strongly influenced by diet and psychological stress. The bidirectional mind–gut axis links emotional states with intestinal sensitivity, making symptom management complex. Conventional dietary interventions, such as the Low FODMAP (L-FODMAP) diet, alleviate physiological distress but often fail to address the underlying psychophysiological dysregulation. Preksha Meditation, a structured mindfulness-based practice rooted in Jain philosophy, focuses on breath awareness and self-observation, potentially enhancing autonomic regulation and reducing symptom severity.
Objective: This study evaluated the combined effects of an eight-week Preksha Meditation programme and L-FODMAP dietary intervention on symptom severity and quality of life (QoL) in patients with IBS.
Methods: A randomised controlled trial (RCT) was conducted with 90 IBS patients aged 18–65 years, assigned to one of three groups: (1) L-FODMAP diet, (2) L-FODMAP diet plus Preksha Meditation, and (3) control (standard IBS care). Pre- and post-intervention data were collected using the IBS-36 questionnaire measuring gastrointestinal, physical, emotional, social, and overall QoL domains. Data were analysed using paired t-tests and ANOVA with significance at p < .05.
Results: Participants in the combined L-FODMAP + Preksha group exhibited the most significant reduction in gastrointestinal and psychological symptoms across all domains (p = .0001), demonstrating improvements in energy, mood, and overall QoL. Both the L-FODMAP-only and control groups showed lesser or negligible improvement.
Conclusion: The integration of Preksha Meditation with dietary intervention offers a holistic, mind–body approach to IBS management. The results support incorporating meditative therapies alongside nutritional strategies for sustainable symptom reduction and improved well-being
PHYTOREMEDIATION: LEVERAGING PLANT-MICROBE INTERACTIONS FOR ENVIRONMENTAL CLEANUP
Get PDFPlant and microbe-based bioremediation is a realizable, cost effective and green approach to remove pollutants in
soil and water. This review assesses major strategies where they focus on stimulation of soil microbial activity in
the rhizosphere, application of plants by steadying, absorption, degrading, and metabolizing hazardous
contaminants; in addition, the roles of plant growth-promoting rhizobacteria (PGPR) and endophytes within the
plant, conferring stress tolerance and nutrient acquisition. Metagenomics and CRISPR/Cas9 genome engineering
have enhanced the prospects of molecular tools for engineering plant microbe interactions improving remediation
potential. For proper functionality, there is a need to integrate two or more functions as shown by the interaction of
phytoremediation and bioenergy production. However, the effort in phytoremediation still has limitations in terms
of implementation at field level such as site heterogeneity, longer time required for remediation, and high cost.
Some of the solutions to these challenges include precision agriculture, bioengineering, plant microbe interactions,
and integrated green technologies. This review indicates that plant-microbe interactions have the ability to be a
cheaper, and eco-friendly remediation technology, and serves as a basis for phytoremediation systems’ research
work and application
Computational Investigation of SomeXanthene-Based Molecules for Optoelectronic Properties: DFT and TD-DFT Study
Get PDFIn this study, we present the design and theoretical investigation of four xanthene-based molecules such as fluorescein (F), fluorescein hydrazide (FH), 2-((4-(dimethylamino) benzylidene) amino)-3′,6′- dihydroxyspiro[isoindoline-1,9′-xanthen] 3-one (DMAB-HIX) and 2-((anthracen-9-ylmethylene) amino)-3',6'-dihydroxyspiro[isoindoline-1,9'-xanthen]-3-one (ANT-HIX) to explore the optical and electronic properties for potential application in optoelectronic devices. Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations were employed to evaluate frontier molecular orbitals, chemical reactivity descriptors, absorption and emission spectra, excitation binding energies, excited-state lifetime and light-harvesting efficiencies. The results reveal that molecular functionalization significantly influences the optoelectronic behaviour of the studied systems. In particular, DMAB-HIX shows a shorter excited-state lifetime, higher light-harvesting efficiency and a lower HOMO-LUMO energy gap, attributed to the strong electron-donating effect of the dimethylamino substituents (DMA). These finding establish clear structure-property relationships and suggest that DMAB-HIX shows potential as a high-performance OLED emissive material.
KEYWORDS
Optoelectronic properties; Xanthene; DFT; light-emitting; excitation energy
Evaluating The Role of Individualized Homoeopathic Treatment in the Management of Urolithiasis: A Case Study
Get PDFThe modern lifestyle and chaotic eating habits is a part of today's life, which has given rise to many diseases among these diseases one is renal stone. Modern medicine relies mostly on surgery for its treatment. It is a common belief in the conventional system in medical science that stones greater than 7 mm usually need to be removed surgically. Renal calculi are hard deposits of minerals and acid salts that stick together in concentrated urine. Surgical intervention is not always mandatory, because there are evidence-based documentations are available where homoeopathy act marvellously in dissolution and expulsion of bigger stones. A patient of urolithiasis reported in a clinical setting. Detailed case taking of the patient was done and individualized homoeopathic medicine was prescribed on the basis of totality of symptoms after repertorization done by Homoeopathic Medical Repertory by Dr. Robin Murphy. Lycopodium was prescribed as the individualized medicine. The clinical status of the patient was analyzed by ultrasonography imaging. constitutional approach of yielded encouraging results. There was symptomatic relief of the patient and post-treatment ultrasonography showed no calculus after homoeopathic interventions.
KEYWORDS
Urolithiasis, Homoeopathy, Lycopodium, Urolithiasis Symptoms Score (USS) Scale
DEVELOPMENT OF STUDENTS’ CREATIVITY WITH THE MEANS OF ART PEDAGOGY
Get PDFA modern teacher of Art pedagogy is not only the transferer of specific knowledge to his students, but also the development of their independent thinking skills, creative approach, their own resources and the formation of an individual teaching style based on the totality of knowledge and experience gained. Professional training of students of pedagogical universities, along with the formation of such qualities and skills as the possession of theoretical material and practical skills, the ability to maintain contact with the audience, openness and goodwill, involves the development of their creativity.
KEYWORDS
Art pedagogy, art counseling, creativity, teaching disciplines, development of personality, imagination, laws of beauty
The Mosquito Microbiome: Implications for Pathogen Transmission and Pharmaceutical Vector Control Strategies
Get PDFMosquito-borne diseases such as malaria, dengue, Zika, chikungunya, and yellow fever continue to pose major public health challenges worldwide. Recent advances in molecular biology and high-throughput sequencing have revealed that mosquitoes harbor diverse microbial communities collectively referred to as the mosquito microbiome. These microorganisms—including bacteria, fungi, viruses, and protozoa—play crucial roles in mosquito development, metabolism, immunity, and vector competence. Increasing evidence demonstrates that the microbiome can significantly influence pathogen acquisition, replication, and transmission within mosquito vectors. Consequently, microbiome-based interventions have emerged as innovative alternatives or complements to conventional chemical insecticides. This review provides a comprehensive synthesis of current knowledge on mosquito microbiome composition, host–microbe–pathogen interactions, immune modulation, and their implications for pathogen transmission. Furthermore, emerging pharmaceutical and biotechnological vector control strategies, such as Wolbachia-based approaches, paratransgenesis, microbial biopesticides, and microbiome manipulation, are critically evaluated. Challenges, ethical considerations, and future research directions are also discussed, highlighting the potential of microbiome-centered strategies for sustainable vector control.
KEYWORDS
Mosquito microbiome; vector competence; arboviruses; malaria; Wolbachia; paratransgenesis; pharmaceutical vector control; microbial biopesticide
ASSESMENT OF BUTTERFLY SPECIES AND RELETIVE ABUNDANCE IN AREA OF GHOT TAHASIL CHAMORSHI DISTRICTGADCHIROLI (M.S.) INDIA
Get PDFThe present study on species diversity and distribution of butterfly was carried out at GhotTahasil ChamorshiDist.Gadchiroli (M.S.).All of the environmental conditions played a significant role in determining the butterfly diversity and density. They are good indicators of climatic, atmospheric and seasonal ecological changes. Being a cold blooded invertebrate’s butterflies is easily shows significant impact by climatic changes. Present investigation carried out for two year during Jan 2023to Dec 2024 at rural area of Ghot.In present investigation, total 60 species were recorded and identified among these include in five Families Nymphalidae with 28 species followed by Pieridae with 10 species and family Papilionidae with 09 species family Lycaenidae with 08 species and family Hesperidae with 05 species.Most of the butterfly species were very commonly called as Brush-footed butterflies followed by Papilionidae commonly called as Swallowtails species and Pierdae commonly called as white and Yellows species.Abundance and biodiversity of butterfly depends on climate change. As per the literature its indicate that all butterflies species has its significant importance in balancing biodiversity of ecosystem so in view of the study need of future planning,climate impact and conservation of host plants and also focus on the current status of diversity and abundance of butterflies in Ghot area near ChamorshiDistrictGadchiroli (M.S.) India
STUDY ON ICHTHYOFAUNALDIVERSITY AND SPECIES RICHNESS INNAVEGAON RESERVOIR, DISTRICT GONDIA (M.S.), INDIA
Get PDFPresenting data on the Navegaon Reservoir's Ichthyofaunal variety is the aim of the study. The reservoir is situated at 20°54'56.62"N latitude and 80°7'11.85"E longitude in the eastern part of Maharashtra State. Because of the numerous communities and forest area that encircle the reservoir, there is human incursion and cattle grazing. The 12-month study period began in November 2023 and ended in October 2024. There are several different kinds of fish at Navegaon Reservoir. In addition to providing baseline data on fish that can be utilized in subsequent research, this study provides information on the ichthyofaunal variation in this area. However, there is still more to be done, and new insights into Ichthyofaunal variety are emerging for the world to see. 23 species were investigates and identified by 8 families and 6 orders for the current investigation. Additionally, they recorded their IUCN Red and residential data status. Ichthyofaunal diversity in this study shows that species diversity rises during the post-monsoon season. The Cyprinidae family has eight species, while the Bagridae family has five. The Ambassidae family has four species, the Siluridae family has two, and the Clariidae, Notopteridae, Poecilidae, and Cichlidae families each have one. The Cyprinidae family dominates all of these families, as the current analysis shows. According to this study on ichthyofaunal variety, species diversity increases during the post-monsoon season, which is correlated with favorable conditions like a enough supply of food and water. Prior to the monsoon, the diversity was restricted, most likely as a result of the summertime water shortage