RepoMed (Medizinische Hochschule Hannover)
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Die Untersuchung klinischer und neurobiologischer Mechanismen von Pädophilie und sexualisierter Gewalt gegen Kinder
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Qualitative Analyse der Belastung von Krebspatienten aus der Perspektive von Patienten und Ärzten
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Morphological and molecular motifs of fibrosing pulmonary injury patterns.
Get PDFInterstitial lung diseases encompass a large number of entities, which are characterised by a small number of partially overlapping fibrosing injury patterns, either alone or in combination. Thus, the presently applied morphological diagnostic criteria do not reliably discriminate different interstitial lung diseases. We therefore analysed critical regulatory pathways and signalling molecules involved in pulmonary remodelling with regard to their diagnostic suitability. Using laser-microdissection and microarray techniques, we examined the expression patterns of 45 tissue-remodelling associated target genes in remodelled and non-remodelled tissue samples from patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), non-specific interstitial pneumonia (NSIP), organising pneumonia (OP) and alveolar fibroelastosis (AFE), as well as controls (81 patients in total). We found a shared usage of pivotal pathways in AFE, NSIP, OP and UIP, but also individual molecular traits, which set the fibrosing injury patterns apart from each other and correlate well with their specific morphological aspects. Comparison of the aberrant gene expression patterns demonstrated that (1) molecular profiling in fibrosing lung diseases is feasible, (2) pulmonary injury patterns can be discriminated with very high confidence on a molecular level (86-100% specificity) using individual gene subsets and (3) these findings can be adapted as suitable diagnostic adjuncts
Two complementary proteomic analyses uncover new regulators of TBX18 transcriptional function
No full textBiomechanische Untersuchung zur retrograden kalkaneotibialen Transfixation instabiler Frakturen des oberen Sprunggelenkes am Leichenpräparat: ein Vergleich der frei Hand-Bohrung vs. der Bohrung mit einem Zielgerät
No full textAssociation between increased antenatal vaginal pH and preterm birth rate: a systematic review
No full textBackground Worldwide, 14.9 million infants (11%) are born preterm each year. Up to 40% of preterm births (PTBs) are associated with genital tract infections. The vaginal pH can reflect changes in the vaginal milieu and, if elevated, indicates an abnormal flora or infection. Objective The aim of the study was to investigate whether an increased antenatal vaginal pH >4.5 in pre-labour pregnant women is associated with an increased PTB rate 4.5 may be associated with a higher risk for PTB. It is recommended to conduct a randomised controlled trial (RCT) to investigate the effectiveness of antenatal pH screening to prevent PTB. Tweetable abstract Pregnant women with an increased vaginal pH >4.5 may be at higher risk to experience preterm birth