RepoMed (Medizinische Hochschule Hannover)
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Relevanz des Essverhaltens im deutschen Gewichtskontrollregister und des hedonischen Hungers in der deutschen Allgemeinbevölkerung: lassen sich hiermit Adipositas hemmende/-fördernde Muster erkennen?
No full textOpen Access an der Medizinischen Hochschule Hannover: Erfahrungen aus der Perspektive der Bibliothek
No full textDie Bibliothek der Medizinischen Hochschule Hannover (MHH) erfasst die Publikationsdaten der MHH und nutzt diese für eine Analyse des kontinuierlich gestiegenen Open-Access-Anteils am Publikationsaufkom- men der MHH. Die in den Prozessen Hochschulbibliografie, Berechnung leistungsorientierter Mittel und Publikationskostenabrechnung gesammelten Daten können für ein umfassendes Monitoring genutzt werden. Der Praxisbericht zeigt zudem die hochschulpolitischen Rahmenbedingungen sowie die Erfahrungen mit dem Publikationsberatungsservice, der Verwaltung des Open-Access-Publikationsfonds und dem institutionellen Publikationsserver RepoMed auf
Entwicklung zweier prognostischer Modelle zur Vorhersage des 10-Jahres Überlebens nach Resektion kolorektaler Lebermetastasen
No full textScreening and characterization of novel chemical compounds inhibiting cytomegalovirus infection
No full textPrävalenz und Ausprägungsgrad einer Aufmerksamkeits-Defizit-Hyperaktivitätsstörung (ADHS) bei Patientinnen und Patienten mit Amyotropher Lateralsklerose (ALS)
No full textLowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome.
No full textAlthough several risk factors exist for acute coronary syndrome (ACS) no biomarkers for survival or risk of re-infarction have been validated. Previously, reduced serum concentrations of anti-ß1AR Ab have been implicated in poorer ACS outcomes. This study further evaluates the prognostic implications of anti-ß1AR-Ab levels at the time of ACS onset. Serum anti-ß1AR Ab concentrations were measured in randomly selected patients from within the PLATO cohort. Stratification was performed according to ACS event: ST-elevation myocardial infarct (STEMI) vs. non-ST elevation myocardial infarct (NSTEMI). Antibody concentrations at ACS presentation were compared to 12-month all-cause and cardiovascular mortality, as well as 12-month re-infarction. Sub-analysis, stratifying for age and the correlation between antibody concentration and conventional cardiac risk-factors was subsequently performed. Serum anti-ß1AR Ab concentrations were measured in 400/799 (50%) STEMI patients and 399 NSTEMI patients. Increasing anti-ß1AR Ab concentrations were associated with STEMI (p = 0.001). Across all ACS patients, no associations between anti-ß1AR Ab concentration and either all-cause cardiovascular death or myocardial re-infarction (p = 0.14) were evident. However among STEMI patients ≤60 years with anti-ß1AR Ab concentration median (14/198 (7.1%) vs. 2/190 (1.1%)); p = 0.01). Similarly, the same sub-group demonstrated greater risk of cardiovascular death in year 1, including re-infarction and stroke (22/198 (11.1%) vs. 10/190 (5.3%); p = 0.017). ACS Patients ≤60 years, exhibiting lower concentrations of ß1AR Ab carry a greater risk for early re-infarction and cardiovascular death. Large, prospective studies quantitatively assessing the prognostic relevance of Anti-ß1AR Ab levels should be considered
