UAX Archive (Univ. Alfonso X el Sabi)
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Fitorremediación de cromo (VI) mediante Lupinus albus y sus microsimbiontes
No full textSánchez Crespo, María; director de proyecto: Muriel Fernández, Candelas2024-2025Grado en BiotecnologíaFacultad de Ciencias de la Salu
MicroRNA-143-3p and miR-452-5p: A Fingerprint for the Diagnosis of Aortic Stenosis in the Geriatric Population.
Full text link: Background/Objectives: Aortic stenosis (AS) is the most common valvular pathology in the geriatric population and is the primary cause of valve replacement. However, misdiagnoses and delays in treatment are common due to comorbidities, frailty, and sedentary lifestyles among elderly individuals. MicroRNAs (miRNAs) are highly conserved molecular regulators involved in various cellular processes and have gained recognition as reliable biomarkers in cardiovascular diseases. In the present study, we evaluated plasma miRNAs as potential biomarkers for the early diagnosis of AS in the geriatric population to identify early therapeutic strategies. Methods: This prospective,
case–control study included 87 individuals over 75 years of age. The participants were divided into AS (n = 58) and control (n = 29) groups. Results: Fifty-four miRNAs were differentially expressed between patients with AS and controls. Among those genes, 29 were upregulated and 25 were downregulated in patients with AS relative to controls.
We selected seven candidate genes (miR-185-5p, miR-143-3p, miR-370-3p, let-7d-3p, miR 452-5p, miR-6787-3p, and miR-21-3p) for experimental validation by qRT–PCR. Only miR-143-3p and miR-452-5p were significantly upregulated in the plasma of patients with AS compared with controls. We developed a multiparametric model by combining the two-miRNA signature with echocardiographic parameters (left ventricular ejection fraction, stroke volume, and global longitudinal strain) to increase diagnostic power; this model yielded sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) values of 78.2%, 70.7%, and 0.837, respectively. Conclusions: In clinical practice, the use of a multiparametric model involving this set of miRNAs combined with echocardiographic variables may improve the accuracy of AS diagnosis and risk stratificationye
Educación económica y desigualdad social en el aula
No full textKhaichoun Harfouch, Salma; director de proyecto: Herrero Lastra, Ángel Carlos2024-2025Máster Universitario en Profesorado de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanza de IdiomasFacultad de Ciencias de la Educació
Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis
Full text linkObjectives: The aim of this study was to investigate the relationship between
active dentin caries (ADC), salivary biochemical parameters, and salivary
microbiota composition in Spanish children and adults.
Methods: Saliva samples were collected from 80 subjects (40 adults and 40
children) divided between ADC and non-ADC. Salivary biochemical
determination was performed by analysing total protein content (TPC) and total
antioxidant activity (TAC) in saliva supernatants. DNA was obtained from the
pellet of saliva samples using the Bacterial DNA kit and analysed with the
Illumina NextSeq platform from all participants. Alpha diversity (Chao, Observed
Features, Shannon and Simpson indices) and beta diversity (PCoA plot and
PERMANOVA procedure) were analysed. In addition, Linear Discriminant Analysis
Effect Size (LEfSe) was used to identify differential taxa between groups. All
statistical analysis were performed with a 95% confidence level (p < 0.05).
Results: No significant associations were found between ADC and salivary
biochemical markers in either the adult or pediatric age group, suggesting that
these parameters alone may not sufficiently reflect cariogenic activity. Microbiota
analysis at the phylum level did not show significant correlations with ADC;
however, distinct associations appeared at the genus and species levels. In adults,
several genera (Corynebacterium, Porphyromonas, Tannerella, Catonella,
Filifactor, Parvimonas, and Dialister) were positively associated with ADC,
reflecting a shift towards a dysbiotic microbiome composition that overlaps with
periodontal and endodontic pathologies. Conversely, Haemophilus was
negatively correlated with ADC, potentially indicating a protective role. At the
species level, a positive correlation with ADC was found with Porphyromonas
gingivalis, Porphyromonas endodontalis, Peptostreptococcus stomatis,
Leptotrichia buccalis, Prevotella oris, or Corynebacterium matruchotii in the adult
population. In children, microbial associations with caries were more limited, with
Scardovia, a well-known acidogenic genus, positively correlated with ADC, and P.
stomatis showing a negative association. Interestingly, P. stomatis exhibited
opposite correlations in adults and children, possibly reflecting age-specific
ecological roles. No significant differences in alpha or beta diversity were found
either in adults or children participants
Propuesta de innovación docente: la inclusión del alumnado TEA en Educación Física, 1º de la ESO
No full textBrugada I Llach, Xavier; director de proyecto: Villamil Cabello, Eduardo2024-2025Máster Universitario en Profesorado de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanza de IdiomasFacultad de Ciencias de la Educació
Estudio de Caso: Intervención Psicológica Online en Ansiedad Social mediante Terapia de Aceptación y Compromiso
No full textGallego García, Noelia; director de proyecto: Álvarez Alonso, María José2024-2025Máster Universitario en Psicología General SanitariaFacultad de Medicin
Diseño de aeronave.
No full textSalaberria Tellechea, Xabier; director de proyecto: Atienza Pascual, Ricardo2024-2025Grado en Ingeniería AeroespacialEscuela de Ingeniería, Arquitectura y Diseñ
Proyecto de igualdad de gnero en Tecnología y digitalización de tercer curso para fomentar el interés de las salidas profesionales STEM en las alumnas de Educación secundaria Obligatoria
No full textVázquez Márquez, Sonia; director de proyecto: Bonet Garrosa, Marta2024-2025Máster Universitario en Profesorado de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanza de IdiomasFacultad de Ciencias de la Educació
Aproximación a la enseñanza de ELE para alumnado inmigrante en los institutos de Educación Secundaria de Las Palmas
No full textFernández Gutiérrez, Sabel; director de proyecto: Tejero López, José Ángel2024-2025Máster Universitario en Enseñanza de Español como Lengua ExtranjeraFacultad de Ciencias de la Educació
Sistema de abastecimiento a Bermeo dentro del plan de abastecimiento a Busturialdea
No full textGutiérrez Rey, Irati; director de proyecto: Soto Pérez, Anselmo César2024-2025Máster Universitario en Ingeniería de Caminos, Canales y PuertosEscuela de Ingeniería, Arquitectura y Diseñ