JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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JIGAR TRANSPLANTATSIYASIDA MONO VA POLIKOMPONENT IMMUNOSUPRESSORLAR QO`LLANILISHINING O’ZIGA XOS KLINIK VA LABORATOR JIHATLARI
Get PDFTransplantologiya rivojlanishining so'nggi yillari immunosupressiya maqsadida turli xil ta'sir mexanizmlariga ega bo'lgan keng doiradagi dori vositalarining joriy etilishi bilan ajralib turdi. Zamonaviy immunosupressiya protokollarida garmonlarni erta bekor qilish uchun, IL-2 retseptorlariga tanlab ta’sir qiluvchi dorilar, kalsinevrin ingibitorlari (CNI) (siklosporin va takrolimus) hali ham asosiy dorilar bo'lib qolmoqda. Bundan tashqari, taniqli dori vositalarining yangı turlari paydo bo'lgan. Minimal immunosupressiyaning maqsadi dorilarning nojo'ya ta'sirini kamaytirish, shuningdek, immunotolerantlikka erishishdir
ONCOMARKERS: THEIR DIAGNOSTIC AND PROGNOSTIC VALUE
Get PDFOncomarkers are biological molecules that indicate the presence of malignant tumors in the body. They are valuable tools for early cancer detection, monitoring treatment effectiveness, and predicting disease progression. This article explores the diagnostic and prognostic value of the most significant oncomarkers, their mechanisms, and their clinical application in oncology practice. It highlights the importance of combining oncomarker analysis with imaging and histopathological methods to achieve higher diagnostic accuracy and better outcomes in cancer management. Cancer biomarkers, also known as oncomarkers, are measurable biological indicators that reflect the presence and behavior of malignant neoplasms. They serve as crucial tools in identifying cancers at subclinical stages, tracking tumor progression, and estimating therapeutic response. Modern oncology has witnessed a rapid evolution in the discovery of both traditional serum markers and novel molecular indicators derived from genomic, proteomic, and metabolomic studies. This article provides an in-depth analysis of how oncomarkers contribute to improving diagnostic precision, guiding personalized treatment decisions, and predicting patient survival outcomes. The paper emphasizes their relevance in precision medicine, discusses the limitations that hinder their routine clinical application, and explores future perspectives for integrating multi-omics and digital technologies into biomarker-based oncology
О‘PKANING SURUNKALI OBSTRUKTIV KASALLIGIDA KOMORBID HOLATLAR
Get PDFTibbiyotning hozirgi bosqichida о‘pkani surunkali obstruktiv kasalligi nafaqat respirator, balki tizimli belgilar bilan nomoyon bо‘lib boshqa a’zolarni ham zararlashi ilmiy tadqiqotlarda bayon qilingan. Bunda nafas a’zolaridagi struktur – funksional buzilishlar, gomeostaz tizimida о‘zgarishlar chaqirib yurak qon tomir, buyrak, kamqonlik, mineral almashinuvi va ruhiy xolatlarida xam patalogik jarayonlar yuzaga kelishiga sabab bо‘ladi. Ushbu maqolada barcha mamlakatlar, shu jumladan respublikamiz axolisi о‘rtasida xam boshqa patalogik jarayonlar bilan birgalikda kechishi sо‘ngi yillarda dunyoda о‘tqazilgan tadqiqotlar asosida taxlil etilgan
GENOMIC-GUIDED THERAPEUTICS: ADVANCING PRECISION MEDICINE THROUGH PHARMACOGENOMICS INTEGRATION IN CLINICAL PRACTICE
Get PDFPharmacogenomics (PGx) is an emerging concept within clinical pharmacy, enabling individualized drug therapy on the basis of unique genetic characteristics. By integrating information from genomic data into patient care, PGx provides opportunities to improve drug efficacy, avoid adverse drug reactions (ARDs) and facilitate evidence-based prescribing. The review will cover the current PGx application models: preemptive and reactive testing; integration with (EHR) electronic health records through clinical decision support systems (CDS), for real-time recommendations, regarding treatment. It also reviews regulatory and guideline references (e.g., FDA biomarker database, Clinical Pharmacogenetics Implementation Consortium (CPIC), Pharm GKB) and their impact on harmonizing PGx-based prescriptions. But even as technology advances, uptake continues to be impeded by barriers such as lack of knowledge among providers; poor infrastructure; high costs (both for patients and healthcare systems), and lack of reimbursement.
Most importantly, to reflect the rise of clinical pharmacists as pivotal opinion leaders driving PGx information into actionable patient care (connecting molecular genetics with medication decision making in cardiology, oncology, psychiatry and infectious diseases) this review is not exhaustive on PGX. Going forward, the convergence of PGx with big data/AI, digital-health platforms and multi-omics analytics could further rationalize scale deployment and predictive accuracy. Combined, these developments are transforming the way we practice pharmacy and ushering in a new era of a more secure, knowledged-based and truly personalized contemporary pharmacotherapy
INNOVATSION HAMSHIRALIK TEXNOLOGIYALARINI REANIMATSIYA AMALIYOTIGA JORIY ETISHNING ILMIY VA AMALIY ASOSLARI
Get PDFUshbu maqolada innovatsion hamshiralik texnologiyalarini reanimatsiya amaliyotiga joriy etishning ilmiy va amaliy asoslari tahlil qilingan. Reanimatsiya bo‘limida zamonaviy texnologiyalarni qo‘llash bemorlarni parvarishlash sifatini oshirish, tezkor klinik qarorlar qabul qilish va xavfsizlik standartlarini mustahkamlashda muhim ahamiyat kasb etadi. Tadqiqotda hamshiralarning axborot-kommunikatsion vositalardan foydalanish ko‘nikmalari, avtomatlashtirilgan monitoring tizimlari, simulyatsion o‘qitish va telehamshiralik texnologiyalarining afzalliklari yoritilgan. Maqola reanimatsiya amaliyotida innovatsion yondashuvlarni joriy etish orqali tibbiy xizmat samaradorligini oshirish yo‘llarini ko‘rsatadi
IDENTIFICATION OF PATHOMORPHOLOGICAL CHANGES IN CARDIAC MUSCLES WITH DEFECTS
Get PDFForensic diagnosis is a special conclusion on the nature of damage, disease, condition of the examined person or the cause of death, compiled on the basis of forensic practice. Forensic diagnosis is based on pathological signs with a combination of morphological changes and damage detected during forensic examination
A STUDY ON NURSES’ KNOWLEDGE TOWARD HEMODIALYSIS AT AL-HILLA TEACHING HOSPITALS
Get PDFBackground: The patient is advised for hemodialysis after the onset of symptoms and complications of chronic renal disease. Patients face different problems such as lifestyle changes and physiological losses (CDC, 2012).
Objectives: The purpose of the study is to evaluate nurses' dialysis knowledge and determine how knowledge relates to employment and demographic characteristics.
Methodology: A descriptive-observational study methodology was used to assess the nurses' understanding of dialysis at teaching hospitals. Using specific criteria, a deliberate sample of 120 nurses who work in the surgical wards was chosen.
Results: According to the results, 107 (89.2%) of the study sample were between the ages of 20 and 30, 85 (70.8%) were women, and 54 (45 percent) of the research sample had a college degree, with 61 (50.8 percent) being married. There were substantial correlations (P < 0.05) between the III nurses' occupational characteristics and their preventative expertise.
Conclusion: The statistical results indicate that nurses have a decent degree of understanding of dialysis, with sixty-five percent of the sample having this information throughout their everyday care in the dialysis units.
Recommendation: To increase the nurses' proficiency with safety precautions, a unique handbook centered on the infection control policy has to be created and given to the dialysis facilities that offer direct patient care
THE ROLE OF RADIATION DIAGNOSTICS IN THE DIAGNOSIS AND TREATMENT OF LIVER TUMORS
Get PDFThe liver is a large and vital organ that performs many functions. Outpatient examinations almost always include assessment of liver function using blood tests, as well as ultrasound examination of the abdominal cavity and others. However, conclusions obtained during regular or targeted medical examinations often put both doctors and patients in a difficult position
SPERMATOZOIDLARDA ATP DARAJASI VA UNING HARAKATLILIKKA TA’SIRI
Get PDFUshbu maqolada spermatozoidlarning energiya almashinuvi va ularning harakatchanligida ATPning o’rni ilmiy jihatdan tahlil qilinadi. Spermatozoidning mitoxondriyalari tomonidan ishlab chiqariladigan ATP miqdori uning dum harakatining ritmi, kuchi va progressive motilitetini belgilovchi asosiy omil ekanligi ko’rsatib o’tiladi. Energiya ta’minotining pasayishi spermatozoidning oldinga siljish tezligini kamaytirishi, tiriklik muddatini qisqartirishi va urug’lantirish qobiliyatiga salbiy ta’sir ko’rsatishi mumkin.Maqolada ATP darajasiga ta’sir qiluvchi omillar – oksidlovchi stress, turmush tarzi, microelement yetishmovchiligi va mitoxondrial funktsiyalar yoritiladi. Tahlil natijalari spermatozoid energiyasini qo’llab quvvatlasherkak reproduktiv salomatligini yaxshilashda muhim omil ekanini ko’rsatadi
ATOPIK DERMATIT RIVOJLANISHIDA IMMUNOLOGIK BUZILISHLAR
Get PDFAtopik dermatit - bu surunkali, qaytalanuvchi, yallig'lanishli teri kasalligi bo'lib, murakkab patogenezga ega bo'lib, genetik moyillik, immun va epidermal to'siqning disfunktsiyasi va atrof-muhit omillarini o'z ichiga oladi. Asosiy simptom qichishishdir; teri shikastlanishlari yengil eritemadan og'ir likenifikatsiya va eritrodermagacha bo'lgan o'zgarishlarni o'z ichiga oladi