JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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C VITAMINI VA UNING INSON HAYOTIDAGI AHAMIYATI
No full textC vitamini – antiskorbut, antisinga omili nomi o‘rta asrlarda epidemiya tavsifli kasallikdan himoya qiluvchi ta’sirga ega ekanligi tufayli kelib chiqqan. Bu vitaminning oziq-ovqat tarkibida yetishmasligi jiddiy kasallikka olib keladi. Singa, asosan bahorda, aholida yetarli miqdorda yashil sabzavot va mevalarni iste’mol qilish imkoniyati bo‘lmagan paytlarda uchraydi. Kimyoviy tuzilishi jihatdan C vitamini L-glyukozaga o‘xshash tuzilishga ega bo‘lgan kislota laktonidir. C vitamini suvda yaxshi eriydigan oq kristall moddadir. Boshqa vitaminlar bilan taqqoslaganda C vitaminining barqarorligi past va uni neytral va ishqoriy muhitda biroz qizdirish osongina parchalanib ketishiga sababchi bo‘ladi. Askorbin kislota kuchli kislota hisoblanadi; uning kislotali xususiyati 2-va 3-uglerod atomlari o‘rtasida joylashgan qaytar dissotsiatsiyalangan ikkita enol gidroksil mavjudligi tufayli namoyon bo‘ladi
CLINICAL AND AUDIOLOGICAL EVALUATION OF PATIENTS WITH CHRONIC OTITIS MEDIA: A PROSPECTIVE STUDY ON TREATMENT OUTCOMES
No full textChronic otitis media (COM) remains a prevalent cause of hearing loss and middle ear morbidity worldwide. This study aims to evaluate the clinical features, audiological profile, and treatment outcomes in patients diagnosed with COM, focusing on both medical and surgical management approaches.
Methods: A prospective observational study was conducted on 60 patients diagnosed with COM at the Department of Otorhinolaryngology No. 2, Samarkand State Medical University, between January 2024 and April 2025. Patients underwent clinical examination, audiological testing (pure tone audiometry), and were treated medically or surgically depending on disease severity. Follow-up assessments were conducted at 3 and 6 months.
Results: The majority of patients presented with otorrhea, hearing loss, and tympanic membrane perforations. Surgical treatment, mainly tympanoplasty, showed significant improvement in hearing thresholds and resolution of symptoms compared to medical therapy alone. The complication rate was low, and patient satisfaction was high postoperatively.
Conclusion: Tympanoplasty offers effective restoration of middle ear function and hearing in patients with COM. Early diagnosis and appropriate treatment planning are essential for improved clinical outcomes
COMPARATIVE ANALYSIS OF MEDICAL AND SURGICAL TREATMENT OUTCOMES IN PATIENTS WITH NASAL POLYPOSIS
No full textNasal polyposis is a chronic inflammatory condition of the nasal mucosa characterized by benign polyp formation. Treatment modalities include medical management with corticosteroids and surgical intervention via functional endoscopic sinus surgery (FESS). This study compares the efficacy and outcomes of medical versus surgical treatment in patients with nasal polyposis.
Methods: A total of 50 patients diagnosed with nasal polyposis were divided into two groups: 25 patients received medical treatment (intranasal corticosteroids, oral steroids), and 25 patients underwent FESS following initial medical therapy failure. Symptom scores, endoscopic findings, and recurrence rates were assessed over 12 months.
Results: Surgical treatment showed superior symptom relief and lower recurrence rates compared to medical therapy alone. Patients undergoing FESS reported improved nasal airflow and decreased nasal obstruction. Medical therapy remained important for initial symptom control and postoperative management.
Conclusion: While medical therapy is effective in controlling symptoms, FESS provides definitive treatment with better long-term outcomes for patients with nasal polyposis
MODERN CLINICAL METHODS OF CONSERVATIVE TREATMENT OF LARYNGOTRACHEITIS IN CHILDREN
No full textThis disease develops independently or is a complication of other upper respiratory tract infections: ARVI, measles, whooping cough, scarlet fever, etc. In severe cases of laryngotracheitis, the patient may need emergency care. Laryngotracheitis is an inflammatory lesion of the mucous membrane of the larynx and trachea, which leads to swelling, spasm of the upper respiratory tract, voice impairment, and a rough "ringing" cough
THE IMPACT OF STROKE REHABILITATION ON FUNCTIONAL RECOVERY AND QUALITY OF LIFE IN PATIENTS WITH ISCHEMIC STROKE
Get PDFStroke remains one of the leading causes of long-term disability worldwide. Rehabilitation plays a critical role in enhancing functional recovery and improving the quality of life for patients after ischemic stroke. This study aims to evaluate the effectiveness of a comprehensive rehabilitation program in promoting motor function, reducing neurological deficits, and enhancing the overall quality of life in stroke survivors. A cohort of 70 ischemic stroke patients was enrolled and followed for six months with structured physical, occupational, and speech therapy interventions. Outcomes were measured using the Modified Rankin Scale (mRS), Barthel Index (BI), and Stroke-Specific Quality of Life Scale (SS-QoL). Results demonstrated significant improvements in motor and cognitive functions, leading to enhanced independence and life satisfaction. This study underscores the vital importance of timely and tailored rehabilitation to optimize post-stroke outcomes
GLOBAL WARMING AND HEALTH: THE IMPACT OF CLIMATE CHANGE ON HUMAN WELL-BEING
Get PDFGlobal isish — sayyoradagi umumiy haroratning uzoq muddatli isishi. Iqlim o‘zgarishi insoniyat salomatligi uchun tobora ortib borayotgan global xavf sifatida tan olinmoqda. Global isish natijasida yuzaga kelayotgan issiqlik to‘lqinlari, havo va suv ifloslanishi, oziq-ovqat xavfsizligining buzilishi, infeksion kasalliklarning geografik kengayishi hamda ruhiy salomatlikka bo‘lgan salbiy ta’sirlar tibbiyot tizimi oldiga yangi klinik va ijtimoiy muammolarni qo‘ymoqda. Ushbu maqolada iqlim o‘zgarishining inson salomatligiga bevosita va bilvosita ta’siri, yurak-qon tomir, nafas olish, yuqumli va ovqat hazm qilish tizimlariga bo‘lgan iqlim omillarining ta’siri, immunitet va ruhiy holatga bog‘liq kasalliklar sonining ortishi haqida bayon qilinadi. Tibbiyot sohasida iqlim xavflarini baholash, profilaktika strategiyalarini ishlab chiqish va sog‘liqni saqlash tizimini iqlimga moslashtirish ushbu ilmiy ishning asosiy yo‘nalishidir
DETECTION OF FACE EMOTION AGE AND GENDER USING MACHINE LEARNING TECHNIQUES
Get PDFFace detection is an important part of surveillance systems, and it has been widely used in computer vision and image processing. Face detection is also the first step of facial feature extraction. Facial feature extraction is a topic that has been focused on by many researchers in computer science, psychology, medicine and related fields and has become increasingly important in recent years. With the help of facial features, machine learning algorithms can estimate ages and classify the genders of people. In this paper, face detection, facial feature extraction, age estimation and gender classification are presented. Firstly, face detection and extraction of facial features like eyes, eyebrows, mouth and nose are presented. Secondly, age estimation and gender classification based on the extracted facial features are explained. Experimental results prove that the face detection algorithm efficiently detects human faces, and the facial feature algorithm accurately locates eyes, eyebrows, mouth and nose. Experimental results also show that, based on the extracted facial features, convolutional neural network architecture estimates the ages of the people and classifies their gender
JISMONIY YUKLAMANING ENDOTELIAL FUNKSIYA VA TROMBOSITLAR AGREGATSIYASIGA TAʼSIRI
Get PDFUshbu nazariy maqolada jismoniy faollikning inson organizmidagi qon tomir endotelial funksiyasi va trombositlar agregatsiyasiga ta’siri tahlil qilinadi. Mavzuning dolzarbligi O‘zbekistonda yurak-qon tomir kasalliklari o‘lim sabablari orasida yetakchi o‘rinda ekani bilan belgilanadi – masalan, 2020 yilning dastlabki choragida mamlakatda qayd etilgan o‘limlarning 62% dan ortig‘i aynan qon aylanish tizimi kasalliklari hisobiga to‘g‘ri kelgan. 30–60 yosh oralig‘idagi, jumladan arterial gipertenziyaga ega va trombositlar faolligi oshgan shaxslarda endotelial disfunksiya va trombositlar agregatsiyasi yurak-qon tomir xastaliklari xavfini oshiradi. Mavjud ilmiy manbalarga tayanib, maqolada aerob (yugurish, veloergometr, piyoda yurish) va anaerob (og‘irlik ko‘tarish, qisqa muddatli yuqori intensiv mashqlar) jismoniy yuklamalarning endotelial vazodilatatsiya funksiyasiga (FMD – flow-mediated dilation) hamda trombositlar agregatsiyasiga (Born usulidagi agregometriya orqali) ta’siri solishtirib ko‘rsatiladi. So‘nggi yillarda o‘tkazilgan tadqiqotlar muntazam jismoniy mashqlar endoteliy vazifasini yaxshilashi va me’yoriy jismoniy faollik trombositlarning giperkayoqiluvchanligini pasaytirishi mumkinligini ko‘rsatmoqda. Shu bilan birga, jismoniy mashqlarning bu jihatdagi ta’siri mashq turiga (aerob yoki anaerob), yuklama intensivligiga va davomiyligiga bog‘liq bo‘lishi mumkinligi ham muhokama qilinadi. Maqolada O‘zbekiston sharoitida profilaktika va reabilitatsiyada jismoniy tarbiya va sog‘lom turmush tarzining ahamiyati hamda tegishli taklif va tavsiyalar keltiriladi
ICHKI MUHIT REZONANSINI MIGREN TRIGGERLARIGA TA’SIRI: TIZIMLI VA ICHAK FAKTORLARINING INTEGRATSIYASI
No full textMigren bu nevrologik kasallik bo‘lib, bosh og‘rig‘i sindromlari orasida eng keng tarqalgan va surunkali og‘riq sindromlaridan biridir. Migren boshning bir tomonida pulsatsiyalovchi, kuchli og‘riq bilan kechadi va bemorlarning hayot sifatini sezilarli darajada kamaytiradi. Keng qamrovli tadqiqotlarga qaramay, migrenning asosiy mexanizmlari hali ham yaxshi o’rganilmagan. So'nggi yillarda tadqiqotchilarning e'tibori migren patogenezida asosiy rol o'ynashi mumkin bo'lgan yallig'lanish jarayonlariga qaratildi. C-reaktiv oqsil kabi yallig'lanish belgilarini o'rganish yangi terapevtik maqsadlarni aniqlashga va migren tashxisini yaxshilashga yordam beradi. Bundan tashqari, gormonal omillar, ayniqsa progesteron darajasi, migren hurujlarining chastotasi va intensivligiga, ayniqsa ayollarda sezilarli ta'sir ko'rsatadi. Ushbu gormonal o'zgarishlarni o'rganish ko'proq yangi davolash yondashuvlarini ishlab chiqishga olib kelishi mumkin. Shuningdek, muhim jihat - bu oshqozon-ichak traktining holati, xususan, tizimli yallig'lanishga va migrenga ta'sir qilishi mumkin bo'lgan ichak mikroflorasi. Koprogrammani o'tkazish bizga ichak mikroflorasi va migren hurujlari o'rtasidagi munosabatni yaxshiroq tushunishga imkon beradi. Shunday qilib, ushbu omillarni har tomonlama o'rganish migrenning patogenezini chuqurroq tushunishga yordam beradi va uni davolash va oldini olish uchun yangi yo'llarni ochishi mumkin
ADVANCEMENTS IN CARDIAC REGENERATION: STEM CELL THERAPY AND TISSUE ENGINEERING IN CHRONIC HEART FAILURE
Get PDFHeart failure with reduced ejection fraction (HFrEF) remains a significant global health burden, accounting for millions of hospitalizations and deaths annually. Recent years have witnessed transformative advances in the pharmacological treatment of HFrEF, offering new hope for patients who previously faced limited therapeutic options. Traditional therapies such as beta-blockers, ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) have been complemented by novel agents like angiotensin receptor-neprilysin inhibitors (ARNIs) and sodium-glucose co-transporter-2 inhibitors (SGLT2i). These newer agents have not only improved patient survival but have also enhanced quality of life, reduced hospital admissions, and mitigated disease progression. In this article, we examine the clinical implications, mechanisms of action, and evidence base of current HFrEF pharmacotherapies, while discussing barriers to implementation and future directions for research and clinical practice. The synthesis of current knowledge aims to guide clinicians toward more effective, evidence-based, and individualized management of HFrEF. Introduction Heart failure with reduced ejection fraction (HFrEF), defined by a left ventricular ejection fraction (LVEF) of less than 40%, is a chronic progressive condition that continues to pose substantial challenges despite therapeutic advancements. It affects millions of individuals globally, with its prevalence rising due to aging populations, improved survival from myocardial infarction, and increased incidence of comorbid conditions such as diabetes mellitus and hypertension. The underlying pathophysiology of HFrEF includes impaired systolic function, maladaptive neurohormonal activation, ventricular remodeling, and systemic inflammation, contributing to a vicious cycle of worsening cardiac performance. Heart failure with reduced ejection fraction (HFrEF) remains a critical global health challenge, associated with high mortality, morbidity, and health system utilization. In recent years, the therapeutic approach has shifted from symptom control to disease-modifying strategies, emphasizing the role of novel pharmacologic agents that modulate key neurohormonal pathways and cellular mechanisms. This article critically evaluates the evolution of pharmacological treatments for HFrEF, focusing on agents that provide hemodynamic support, neurohormonal inhibition, and metabolic optimization. Special emphasis is placed on the integration of emerging evidence into clinical guidelines, challenges in therapeutic implementation, and prospects for personalized medicine in heart failure care. This comprehensive review aims to support clinicians in designing optimized pharmacologic regimens and identifying potential gaps in the current evidence base to stimulate future research.
Historically, treatment of HFrEF focused on symptomatic relief through diuretics and vasodilators. However, landmark trials in the late 20th century demonstrated the survival benefit of neurohormonal modulation using ACE inhibitors and beta-blockers. More recently, paradigm-shifting therapies such as ARNIs and SGLT2 inhibitors have shown significant additional mortality and morbidity benefits. The most recent heart failure guidelines from the American Heart Association (AHA), American College of Cardiology (ACC), and European Society of Cardiology (ESC) endorse a quadruple foundation therapy consisting of ARNI, beta-blocker, MRA, and SGLT2 inhibitor.
This review synthesizes the clinical evidence and mechanistic insights surrounding these pharmacologic agents, highlighting the importance of early initiation, individualized titration, and multidisciplinary care approaches to optimize outcomes in HFrEF. It also considers real-world barriers to implementation and strategies to bridge the evidence-practice gap