JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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MUSHAK QISQARISHINING BIOLOGIK VA FIZIK MEXANIZMLARI HAMDA ULARNING AMALIY AHAMIYATI
Get PDFIshda mushaklarning qisqarishida sodir bo‘ladigan biologik va fizik energiya aylanishi haqida fikr yuritiladi. Mushak faoliyati murakkab mexanizmlarga asoslanadi. Kimyoviy energiya mexanik ish va issiqlikka aylanadi. Maqolada bu jarayon biologik, bioximik va fizik nuqtayi nazardan tahlil qilinib, uning tibbiyot va sportdagi amaliy ahamiyati ko‘rsatib beriladi
ASSESSMENT OF BIOCHEMICAL AND ENDOCRINE CHANGES IN BRUCELLOSIS-ASSOCIATED ABORTION IN EWES
Get PDFBackground: Abortion in sheep causes significant economic losses and poses potential public health risks due to zoonotic pathogens like Brucella spp. Changes in the biochemical and hormonal levels of affected ewes may indicate problems in organ function and disruptions in reproduction.
Objective: This study aimed to evaluate the changes in specific biochemical and hormonal parameters in aborted and healthy ewes in Thi-Qar province, Iraq.
Methods: Thirty ewes were chosen, consisting of 15 with recent abortions and 15 healthy controls. Blood samples were taken through jugular venipuncture, and serum was separated for analysis. Biochemical parameters, including creatinine, uric acid, ALT, AST, ALP, and GGT, were measured. Hormonal profiles, including FSH, LH, progesterone, and estrogen, were also assessed. Statistical analysis using Student’s t-test, considering p < 0.05 significant, was performed.
Results: The aborted ewes showed significantly lower creatinine levels (0.583 ± 0.026 mg/dL) and higher ALT (29.40 ± 1.64 U/L) and AST (124.1 ± 2.92 U/L) compared to the controls (0.702 ± 0.039 mg/dL, 23.48 ± 1.58 U/L, 88.64 ± 4.72 U/L, respectively; p < 0.05). There were no significant differences in uric acid, ALP, GGT, or reproductive hormones (FSH, LH, progesterone, estrogen) between the groups.
Conclusion: Abortion in ewes associated with brucellosis is linked to changes in liver and kidney function, while levels of reproductive hormones may remain stable shortly after the abortion. Monitoring biochemical parameters offers important insights into organ function and can help detect systemic effects early. Effective control measures, including vaccination and biosecurity, are vital for reducing reproductive losses and improving the health of the flock
ОДДИЙ ТОҒРАЙХОН (ORIGANUM VULGARE L.) НИНГ УРУҒ УНУВЧАНЛИГИ
Get PDFТошкент вохаси шароитида интродукция қилинган Origanum vulgare нинг лаборатория шароитида уруғ унувчанлиги аниқланди. Тажриба 3 такрорлиқда турли хил сақланган уруғларда олиб борилди ва қулай харорат аниқланди
Chronic Constipation in Children: Causes and Treatment Methods
Get PDFChronic constipation in children is a common condition that significantly impacts both physical and emotional health. Various factors, including dietary habits, insufficient fluid intake, physical inactivity, and psychological stress, influence it. Despite its prevalence, there remains a gap in identifying the most effective treatment strategies for this condition. This study aims to address this gap by reviewing existing treatment methods and evaluating their effectiveness. A systematic review of clinical trials, expert opinions, and treatment guidelines was conducted to analyze common treatment approaches. The findings indicate that a combination of dietary modifications (increased fiber and fluid intake), pharmacological treatments (laxatives and stool softeners), and behavioral interventions (biofeedback and positive reinforcement) offers the most effective solution for managing chronic constipation. Moreover, an individualized approach tailored to the specific causes and needs of each child is essential for successful treatment. The study emphasizes the need for a comprehensive, personalized management plan that incorporates both medical and behavioral strategies to improve long-term outcomes and the quality of life for children suffering from chronic constipation
BAKTERIYALARNING ANTIBIOTIKLARGA NISBATAN REZISTENTLIK XUSUSIYATINING PAYDO BO’LISH MEXANIZMLARI, TIBBIYOTDA ULARGA QARSHI KURASHISH USULLARI
Get PDFUshbu maqolada bakteriyalarning antibiotiklarga va dori vositalariga qarshilik ko’rsatish xususiyati, uning paydo bo’lish mexanizmlari, inson salomatligiga ta’siri va uni oldini olish yo’llari tahlil qilinadi. Bakterial populyatsiyalarda rezistentlik xususiyati antibiotiklarning noto’g’ri qo’llanishi, bakteriyalarning genetik mutatsiyasi, antibiotiklarga qarshilik qilish va moslashuvchanlik xususiyatlari natijasida yuzaga keladi. Plazmidlar tarkibidagi DNK orqali ta’minlanadigan genlar almashinuvi, Efflyuks nasoslari kabi murakkab mexanizmlar bakteriyalar hayot faoliyatining davomiyligini ta’minlashga yordam beradi. Antibiotiklarga chidamlilik xususiyatini paydo bo’lishini o’rganish tibbiyotda patogen bakteriyalarning taqalishini oldini olish va ularga qarshi kurashish uchun asos bo’lib xizmat qiladi
« KISTIK FIBROZLI BOLALARDA CFTR GEN MUTATSIYALARINING TAHLILI VA ULARNING ENDOKRIN PATOLOGIYASI BILAN KLINIK ALOQASI
Get PDFKistik fibroz - bu CFTR genidagi mutatsiyalar natijasida kelib chiqqan genetik kasallik. Ushbu autosomal retsessiv kasallik ko'plab hududlarda yangi tug'ilgan chaqaloqlarni skrining yordamida tashxislanadi, boshqa hududlarda esa tashxis tan olingan ko'p organli klinik ko'rinishlar, terdagi xlorid konsentratsiyasining oshishi yoki CFTR mutatsiyalari klasteriga asoslanadi. Kistik fibroz ko'pincha umr ko'rish davomiyligining qisqarishi bilan bog'liq va o'limning eng keng tarqalgan sababi o'pkaning so'nggi bosqichidir
EMBRYOLOGICAL AND MOLECULAR BASIS OF NEURAL TUBE FORMATION AND ITS DEVELOPMENTAL DEFECTS
Get PDFThe formation of the neural tube represents a pivotal event in early embryogenesis, serving as the foundation for the central nervous system. This complex morphogenetic process, beginning during the third and fourth weeks of gestation, involves coordinated cellular movements, genetic regulation, and molecular signaling. Primary neurulation converts the neural plate into a closed neural tube through bending, elevation, and fusion of neural folds, while secondary neurulation extends the tube into the caudal regions. Key molecular pathways—including the Sonic Hedgehog (SHH) and Planar Cell Polarity (PCP) signaling systems—govern the spatial and temporal control of neural plate shaping and closure.
Disruptions in these processes result in neural tube defects (NTDs), which encompass a spectrum of congenital anomalies such as anencephaly, myelomeningocele, and spina bifida. These malformations often originate from impaired neurulation, abnormal gastrulation, or defective secondary tube formation. Clinically, NTDs are among the most serious developmental disorders, contributing significantly to perinatal morbidity and mortality. Maternal folate deficiency, by altering one-carbon metabolism and DNA methylation, remains a major modifiable risk factor. Early prenatal detection through biochemical screening and ultrasonography enables prompt intervention.
This review synthesizes the embryological, cellular, and molecular mechanisms underlying neural tube development and highlights their clinical implications, emphasizing the importance of nutritional and genetic regulation in preventing neural tube defects
USE OF OSTEOPLASTIC MATERIALS IN IMPLANTOLOGY
Get PDFOsteoplastic materials play a fundamental role in implantology by restoring bone volume, improving osseointegration, and ensuring long-term success of dental implants. This study evaluates natural and synthetic grafts, focusing on their biological properties, mechanisms of bone regeneration, and clinical outcomes in alveolar ridge augmentation and sinus lift procedures. Through assessment of 120 patients undergoing guided bone regeneration, sinus augmentation, and ridge augmentation, the study explores graft integration rates, implant stability, complication profiles, and long-term functional outcomes. Findings demonstrate that osteoplastic materials provide predictable bone regeneration, enhance implant success, and reduce postoperative complications when used with proper surgical protocols. Biocompatibility, regenerative capacity, and resorption rate determine clinical efficiency, with xenografts and alloplastic materials showing comparable outcomes to autografts in controlled indications. The investigation focuses on clinical performance, regenerative potential, and long-term functional outcomes of osteoplastic materials used in implant-related bone reconstruction. Evidence from a structured patient cohort highlights the effectiveness of natural, synthetic, and combination grafts in rebuilding deficient alveolar ridges and stabilizing implant placement. Emphasis is placed on biological integration, structural maintenance, radiographic bone density improvement, and postoperative healing dynamics. Clinical observations confirm that contemporary grafting materials enable predictable new-bone formation, high implant stability, and reduced complications when combined with guided regenerative protocols and precise surgical handling. The findings support material-specific indications, demonstrating that bioactive substitutes and hybrid formulations can successfully replace or complement autogenous bone harvesting, minimizing surgical morbidity and expanding implant therapy applicability
MODERN LASER TECHNOLOGIES IN PERIODONTAL THERAPY: EFFICACY, CHALLENGES, AND PROSPECTS – MINI REVIEW
Get PDFBackground/Objectives: This mini-review examines the effectiveness and safety of laser therapy in periodontal care, with an emphasis on therapeutic outcomes, patient comfort, and cost considerations. Methods: A comprehensive literature review was performed, covering studies published between 2010 and 2024. The search, conducted in January 2024, included major electronic databases such as PubMed, SCOPUS, EMBASE, the COCHRANE Library, and ScienceDirect. Keywords and MeSH terms used in the search strategy included “laser therapy,” “periodontal disease,” “efficacy,” and “safety.” Results: From an initial pool of 884 articles, 98 papers were shortlisted based on titles and abstracts. Following full-text assessment and strict inclusion/exclusion criteria, 16 studies were ultimately selected for detailed evaluation. Conclusions: The review highlights significant research gaps and points toward evolving innovations in laser-assisted periodontal therapy. It underscores the necessity for standardized clinical protocols, long-term follow-up studies, and continued technological advancements to improve clinical effectiveness and broaden accessibility
БРОНХИАЛ АСТМА: ЗАМОНАВИЙ ДАВОЛАШ РЕЖАЛАРИ ВА ФЕНОТИПГА АСОСЛАНГАН ЁНДАШУВ
Get PDFБронхиал астма (БА) дунё бўйлаб миллионлаб инсонларни зарарлайдиган сурункали яллиғланиш касаллиги бўлиб, унинг давоси доимий ривожланишда. Ушбу мақола БАни бошқаришнинг замонавий стратегиялари, жумладан, Global Initiative for Asthma (GINA) 2024 тавсияларидаги асосий ўзгаришларни таҳлил қилади. Асосий эътибор фенотипга асосланган ташхис қўйиш ва даволаш режаларига қаратилган бўлиб, бу даволаш самарадорлигини оширишга қаратилган. Мақолада назоратни баҳолаш мезонлари, асосий базис терапия (ИГКС/LABA), "зарурат бўлганда" қўлланиладиган SMART-терапиянинг аҳамияти ва оғир астмада биологик препаратлардан фойдаланиш механизмлари муҳокама қилинади. Замонавий даволаш режалари астманинг доимий назоратини таъминлаш, касаллик хуружларини камайтириш ва беморлар ҳаёт сифатини яхшилашга қаратилган