JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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THE ROLE OF ANTIALLERGIC DRUGS IN MEDICAL PRACTICE AND THE RELEVANCE OF THEIR IMPROVEMENT
Get PDFThe most prevalent chronic illnesses that persist throughout a patient's life are allergic diseases. In addition to significantly lowering patients' quality of life, they also result in increased absenteeism and decreased productivity, which raises societal costs. Therefore, one of the primary issues for public health is the effective and safe treatment of allergic disorders, which should be handled by all family medicine specialists, internists, and pediatricians in conjunction with allergists, otorhinolaryngologists, and dermatologists. The most popular application of antihistamines is in the management of allergies. There are several dozen medications on the pharmaceutical market, and their generic versions are heavily marketed as being highly successful in treating allergic conditions. What is the reality? What information comes from observational studies and clinical trials? Are all medications equally safe and effective for the patient? A panel of specialists from a variety of medical specialties stated that treating allergies improperly might put patients at serious risk and that drugs that appear to have similar effects can differ significantly. As a result, a group of specialists collected the most recent information from all of the scientific literature and examined the most recent guidelines and recommendations created by scientific associations. This essay summarizes these research and emphasizes how crucial it is for the patient to select the right medication to address his allergies
EVALUATION OF TONSILLECTOMY OUTCOMES IN RECURRENT TONSILLITIS AMONG ADULTS AND CHILDREN
Get PDFThis article presents a comprehensive evaluation of tonsillectomy outcomes in patients with recurrent tonsillitis, comparing postoperative results, complication rates, and quality-of-life improvements in both adult and pediatric populations. Tonsillectomy, one of the most frequently performed otolaryngologic surgeries worldwide, remains the definitive treatment for chronic or recurrent tonsillar infections unresponsive to medical therapy. The study assesses clinical effectiveness, frequency of infection reduction, postoperative morbidity, and overall patient satisfaction following tonsillectomy. Results demonstrate a significant decrease in the number and severity of throat infections, improved sleep quality, and enhanced overall well-being after surgery in both age groups. However, adults were found to experience higher rates of postoperative pain and longer recovery times. The findings confirm the long-term benefits of tonsillectomy for recurrent tonsillitis, supporting its continued role in modern otolaryngologic practice
MOLECULAR DETERMINANTS OF METABOLIC HOMEOSTASIS IN STEM CELL BIOLOGY
Get PDFMany tissues and organ systems possess inherent regenerative capacity that is sustained by resident stem cell populations. Accumulating evidence indicates that cellular metabolic homeostasis is a key determinant of stem cell fate decisions, tissue regeneration, and overall tissue maintenance. Therefore, a comprehensive understanding of the mechanisms governing metabolic homeostasis in stem cells is essential for elucidating how tissue integrity is preserved and for identifying new strategies in disease treatment. This review highlights the interplay between metabolic regulation and molecular signaling pathways in stem cells. In addition, we explore potential therapeutic targets related to metabolic homeostasis, while outlining current challenges and future perspectives in the development of metabolism-based therapies
CORRELATION BETWEEN INSULIN RESISTANCE AND MENSTRUAL IRREGULARITIES IN WOMEN WITH PCOS
Get PDFPolycystic Ovary Syndrome (PCOS) is a complex endocrine disorder characterized by reproductive, metabolic, and hormonal disturbances. Among the common manifestations are menstrual irregularities and metabolic alterations, including insulin resistance. This study investigates the relationship between insulin resistance and menstrual cycle abnormalities in women diagnosed with PCOS, aiming to understand the extent to which metabolic dysfunction contributes to reproductive irregularities. By employing both clinical and laboratory assessments, the research identifies correlations between insulin sensitivity indices and the frequency and regularity of menstrual cycles. Findings reveal a significant association between elevated insulin resistance and disrupted menstrual patterns, highlighting the importance of early metabolic evaluation in PCOS management. These insights may inform individualized treatment strategies that address both metabolic and reproductive dimensions of the syndrome, ultimately improving patient outcomes and quality of life. Polycystic Ovary Syndrome (PCOS) represents a multifaceted endocrine disorder that affects a significant proportion of women of reproductive age worldwide. Its pathophysiology involves a complex interaction between hormonal, metabolic, and genetic factors, often resulting in both reproductive and metabolic complications. Among the most frequently observed clinical features are menstrual cycle irregularities, ranging from oligomenorrhea to amenorrhea, alongside metabolic disturbances such as insulin resistance. This study aims to examine the correlation between insulin resistance and menstrual abnormalities in women diagnosed with PCOS, focusing on how hyperinsulinemia influences ovarian function and menstrual regularity. Using a combination of anthropometric measurements, hormonal profiling, and validated insulin sensitivity indices, the research identifies significant associations between metabolic dysfunction and reproductive irregularities. The findings underscore the necessity of early metabolic evaluation in PCOS management to optimize both reproductive outcomes and long-term health. The study emphasizes that targeting insulin resistance can contribute to improved menstrual regularity and reduce the risk of associated comorbidities, highlighting the clinical relevance of integrative treatment strategies
YOD MIKROELEMENTINING INSON ORGANIZM UCHUN AHAMIYATI
Get PDFMazkur ishda inson organizmidagi eng zarur kimyoviy elementlardan biri - yod mikroelementining inson organizm uchun tutgan o‘rni to‘g‘risida ma'lumotlar bayon etilgan
SUT BEZI SARATONINI SKRINING ASOSIDA ANIQLASHDA MAMMOGRAFIYA VA ULTRATOVUSH TEKSHIRUVI (UTT) USULLARINING TAQQOSLAMA TAHLILI
Get PDFMazkur maqolada O‘zbekiston Respublikasida ayollar o‘rtasida o‘tkazilgan skrining tekshiruvlari asosida sut bezi saratonini erta aniqlashda mammografiya va ultratovush tekshiruvi (UTT) usullarining diagnostik imkoniyatlari taqqoslab tahlil qilindi. Har ikkala usulning sezuvchanlik, spetsifiklik va klinik ahamiyati baholanib, ularning skrining tizimidagi o‘rni aniqlandi. Tadqiqot natijalari mammografiya sut bezi saratonini “doklinik” bosqichda aniqlashda asosiy skrining usuli ekanligini, “UTT” esa qo‘shimcha diagnostik vosita sifatida muhim ahamiyatga ega ekanligini ko‘rsatdi
CLINICAL AND SURGICAL OUTCOMES OF MANDIBULAR OSTEOSYNTHESIS PERFORMED VIA INTRAORAL AND EXTRAORAL APPROACHES USING SHAPE-MEMORY IMPLANTS
Get PDFMandibular fractures represent a common maxillofacial injury requiring precise stabilization to restore occlusion, function, and facial symmetry. The development of shape-memory implants has introduced new possibilities for osteosynthesis by providing stable fixation with adaptive mechanical properties. This article presents a comprehensive analysis of clinical and surgical outcomes of mandibular osteosynthesis performed through intraoral and extraoral approaches using shape-memory implants. The study evaluates operative feasibility, postoperative stability, complication rates, and functional recovery, aiming to determine the comparative effectiveness and clinical advantages of each surgical approach.
Mandibular fracture management continues to evolve with the introduction of advanced fixation systems designed to enhance biomechanical stability and promote optimal bone healing. Shape-memory implant technology has gained attention due to its ability to provide continuous adaptive compression and simplified fixation mechanics. This abstract presents an expanded overview of clinical effectiveness, surgical practicality, and postoperative recovery associated with different surgical access routes, emphasizing outcome reliability, patient safety, and functional rehabilitation
HEARING LOSS IN CHILDREN: EARLY DIAGNOSIS AND INTERVENTION STRATEGIES
Get PDFThis article presents a comprehensive analysis of pediatric hearing loss, emphasizing the critical importance of early diagnosis and timely intervention to support optimal speech, language, cognitive, and social development. Hearing impairment in children may result from genetic, prenatal, perinatal, or environmental factors, and its early identification remains a key determinant of developmental outcomes. The study evaluates the effectiveness of newborn hearing screening programs, auditory brainstem response (ABR) testing, otoacoustic emissions (OAE), and behavioral audiometry as diagnostic tools. Additionally, it explores rehabilitative strategies including hearing aids, cochlear implants, auditory-verbal therapy, and parental engagement in early education programs. Findings reveal that early detection—ideally within the first six months of life—combined with prompt intervention, leads to significantly improved communication skills, academic performance, and psychosocial integration. The research underscores the necessity of multidisciplinary collaboration among otolaryngologists, audiologists, pediatricians, and speech therapists in implementing evidence-based hearing care for children
EARLY STRUCTURAL ALTERATIONS OF THE KIDNEY AND POTENTIAL BIOMARKERS IN DIABETIC NEPHROPATHY
Get PDFDiabetic nephropathy represents one of the most severe microvascular complications of diabetes mellitus and continues to be associated with rising prevalence and mortality worldwide. In current clinical practice, renal function is primarily evaluated using the albumin excretion rate and estimated glomerular filtration rate. However, substantial structural damage to the glomerulus often precedes the onset of microalbuminuria, while creatinine-based estimation of glomerular filtration rate may underestimate early renal impairment. Early identification of diabetic nephropathy is therefore critical for timely therapeutic intervention, preservation of renal function, and delay of disease progression.
There is a pressing need for sensitive biomarkers capable of reflecting early kidney structural alterations. This review focuses on initial glomerular and tubular morphological changes in diabetic nephropathy, with particular emphasis on glomerular injury markers, including SMAD1 and podocalyxin, as well as tubular injury markers such as neutrophil gelatinase-associated lipocalin (NGAL), netrin-1, and liver-type fatty acid–binding protein (L-FABP). We summarize currently investigated protein biomarkers, analyze their associated biological processes, and briefly review emerging proteomic and single-cell RNA sequencing approaches used to identify novel diagnostic markers in diabetic nephropathy
ОШҚОЗОН САРАТОНИНИНГ ЭРТА БОСҚИЧИДА ЭНДОСКОПИК ДИАГНОСТИКА ВА ДАВОЛАШНИНГ ЗАМОНАВИЙ ЮТУҚЛАРИ
Get PDFОшқозон саратонини ерта босқичлардааниқлаш бу о'лим ҳавфини камайтиришга қаратилган асосий омиллардан бири ҳисобланади.Сўнгги йилларда юқори аниқликдаги эндоскопик визуализатсия усуллари ривожланиб бориши бу барча турдаги саратонни эрта босқичида ташхис қўйишда,саратоннинг морфологик ва структуравий хусусиятини юқора даражада баҳолаш ва саратоннинг тарқалганлик чегараларини аниқлаш имкониятини берди. Ушбу мақолада эндоскопик визуализатсия усуллари текширув натижаларидан фойдаланган ҳолда бемор ҳолатининг индивидуал параметрларига мос равишда даволаш режасини белгилаш имкониятлари илмий жиҳатдан асослаб берилади. Бошланғич диагностик хулосани, лимфа тугунларига тарқалиш частотаси , радикал оператив даводан кўз юмган ҳолда орган сақловчи даволаш методларини танлаш имконияти ва тадқиқотлар натижасида олинган маълумотлар асосида беморларнинг функсионал ҳолати ва ҳаёт сифат даражасига ижобий таъсир этиши кўрсатилиб ўтилади. Тадқиқот натижалари шуни исботлайдики, аниқ ташхис қо'йиш босқичидан бошлаб о'смаларни то'лиқ олиб ташлашига қаратилган даволаш усулларигагача бўлган кенг ко'ламли,интегратсиялашган эндоскопик усуллар то'плами ошқозон саратонини эрта босқичларида даволаш учун клиник амалиётда назарий ва амалий жиҳатдан энг то'г'ри методлардан бири ҳисобланади