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An Exploratory Study of Resilence in Adult Children Affected by Parental Incarceration
No full text2023Parental incarceration is as an adverse childhood experience which negatively affects a child’s well-being, mental health, academic performance, and socio-economic level. More than 5 million children have experienced having one or both parents incarcerated before they reach age 18. Previous research has illustrated that many negative outcomes can be mitigated by protective factors such as compassionate caregivers, positive interpersonal relationships, and social support. The literature is scant regarding the lived experiences of Adult Children who were impacted by parental incarceration. The purpose of this phenomenological study was to explore the lived experiences and resilience of Adult Children impacted by the incarceration of one or both parents.
This exploration of lived experiences of adult children impacted by parental incarceration allowed for a greater understanding of their life while one or both parents were incarcerated as well as whom or what they considered their biggest support during this time in their lives. This study utilized the phenomenological research design approach where the researcher was the primary instrument of data collection. The sample consisted of 8 individuals: 7 female and 1 male. Six participants lived in Georgia, one lived in California, and one lived in Florida. Semi-structured interviews were completed via zoom. The analysis of the interviews produced 8 central themes: support, trauma, protection, school as a safe place, helping others, independence, spirituality, and success.
The significant finding of this research were the protective factors of support and resiliency. Each participant identified a supportive person/people in their life during the time of their parent(s) incarceration and all participants defined themselves as being resilient. The results of this study are relevant to how this population can be serviced at different times throughout their lives and provides a greater understanding of the individual and collective needs of those who were impacted by parental incarceration. This study encourages further research to determine how counselors, school leaders and politicians are able to assist families impacted by incarceration as well as promote the need for the discussion about the physical and emotional safety and wellbeing of children.Rowland, KarenRedmond, DonHenderson, TerahPsy.D
CEREBROVASCULAR COMPLICATIONS OF SARS-CoV-2 IN TYPE-2 DIABETES
No full text2023Diabetics are more vulnerable to SARS-CoV-2 cerebrovascular complications, including brain fog, cognitive impairment, and strokes. This study aims to identify the molecular mechanisms of SARS-CoV-2-induced cerebrovascular dysfunction in diabetics. We hypothesize that SARS-CoV-2 exacerbates diabetes-induced cerebral oxidative stress and inflammation via activation of the destructive arm of the renin-angiotensin system (RAAS) and toll-like receptor (TLR) signaling.
Methods: SARS-CoV-2 spike protein interacts with human ACE2 receptors but not murine Ace2. Therefore, type-two diabetes was induced in humanized ACE2 (hACE2) transgenic knock-in mice using low-dose streptozotocin followed by eight weeks of a high-fat diet. Recombinant SARS-CoV-2 spike protein was injected intravenously in control and diabetic mice. Cognitive functions were tested using Y-maze and Barnes maze. Cerebral blood flow was measured using laser speckle imaging. RAAS system and TLR signaling were assessed using RT-PCR and western blot analysis. The cerebrovascular architecture was measured using immunohistochemistry. Human brain microvascular endothelial cells were treated with hyperglycemia (25 mM glucose) to mimic diabetic conditions.
Results: Spike protein exacerbated diabetes-induced cerebrovascular oxidative stress and inflammation as detected by increased (NOX1, NOX5) and (Il-6, Il-1β, and TNF-α) gene expression, respectively. Spike protein enhanced the destructive RAAS arm (angiotensin ll and AT1R) at the expense of the RAAS protective arm (ACE2 and AT2R) gene expression (P<0.05). In parallel, spike-protein exacerbated TLR signaling in diabetes as indicated by the increase in TLR-8 receptor and its ligands (HMGB1 and S100) and downstream adaptor proteins (MyD88, TRAF6, and NF-κB) expression
(P<0.05). Spike-protein increased cerebrovascular rarefaction and decreased blood flow and cognitive functions in diabetes compared to control (P<0.05).
Conclusion: SAR-CoV-2 spike protein intensified RAAS and TLR signaling in diabetes, increasing cerebrovascular damage and cognitive dysfunction. Targeting RAAS and TLR singling are possible therapeutic strategies to protect against SAR-COV-2-induced cerebrovascular dysfunction in diabetes.Abdelsaid, MohammedRotschafer, SarahChinnadurai, RaghavanM.S
Minutes of the General Association of the Baptist Denomination in Georgia [1826]
No full textMinutes of the Georgia Baptist Convention, 182
Minutes of the Tenth Anniversary of the Baptist Convention for the State of Georgia [1831]
No full textMinutes of the Georgia Baptist Convention, 183
Minutes of the Eighteenth Anniversary of the Georgia Baptist Convention [1839]
No full textMinutes of the Georgia Baptist Convention, 183
Minutes of the Thirty-Third Anniversary of the Georgia Baptist Convention [1854]
No full textMinutes of the Georgia Baptist Convention, 185
Minutes of the Forty-Second Anniversary of the Georgia Baptist State Convention [1864]
No full textMinutes of the Georgia Baptist Convention, 186
Minutes of the Fifty-Second Anniversary of the Baptist Convention of the State of Georgia [1874]
No full textMinutes of the Georgia Baptist Convention, 187
Minutes of the Seventy-Second Anniversary of the Baptist Convention of the State of Georgia [1894]
No full textMinutes of the Georgia Baptist Convention, 189
Minutes of the Forty-Fifth Anniversary of the Georgia Baptist State Convention [1867]
No full textMinutes of the Georgia Baptist Convention, 186