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Minutes of the Forty-Seventh Anniversary of the Georgia Baptist State Convention [1869]
No full textMinutes of the Georgia Baptist Convention, 186
Minutes of the Fifty-First Anniversary of the Baptist Convention of the State of Georgia [1873]
No full textMinutes of the Georgia Baptist Convention, 187
EXAMINING PTSD, PTG, ALCOHOL USE, AND DRUG USE IN VETERANS AND ACTIVE-DUTY SERVICE MEMBERS: A MIXED METHODS APPROACH
No full text2023Military service members are at increased risk for developing post-traumatic stress disorder (PTSD) compared to the general population due to combat exposure and experiencing other traumatic events. PTSD is a mental health disorder associated with high levels of depression, substance use, mortality, and impaired functioning. However, research suggests there is a significant relationship between experiencing traumatic events, being diagnosed with PTSD, and exhibiting post-traumatic growth (PTG). PTG has been shown to protect persons from becoming overwhelmed with PTSD-associated stress, thus leading to a greater sense of stress management. Although the relationship between PTSD and PTG has been the subject of several studies, there have been few research studies devoted to assessing this relationship in active-duty service members and veterans in the southeastern region of the contiguous United States. Similarly, very little is known about the impact of drug and alcohol use on the relationship between PTSD and PTG in this population. The purpose of this study was to examine the relationship between PTSD and PTG in active-duty service members and veterans in the southeastern region of the contiguous United States and how this relationship is mediated and moderated by drug and alcohol use. The study population consisted of active-duty service members and veterans in the southeastern region of the contiguous United States, who served for at least two years or completed one deployment, and who are fluent in English. Participants were recruited from military-affiliated and -adjacent organizations, such as support groups, non-profit organizations, shelters, recruitment offices, etc. Data was collected via surveys and interviews assessing drug and alcohol use, PTG factor exhibition, and PTSD symptoms. This study’s results may help to identify specific mental health needs within the southeastern United States’ active-duty and veteran population, as well as aid in the development of support systems and culturally competent treatment options. By understanding more about the relationship between PTSD and PTG, facilitators and barriers to PTG, and the impact of substance use on the relationship between PTSD and PTG in this population, mental health professionals and communities will be better equipped to meet military mental health needs.Mincey, Krista D.Hollar, David W.Lian, BradleyStinson, Morgan A.D.Phil
POLYPHARMACOLOGY OF MITRAGYNA SPECIOSA (“KRATOM”) ALKALOIDS
No full text2023The nation’s persistent opioid epidemic requires innovative treatment interventions. Mitragyna speciosa, or kratom, is a plant native to Southeast Asia that contains dozens of potentially active alkaloids. The most abundant and best characterized of these alkaloids is mitragynine, which accounts for up to 66% of crude alkaloid extracts. Kratom preparations have been traditionally used for their analgesic properties and as a mild stimulant to combat work fatigue. Over the past decade, kratom has become a popular drug in the United States, where pulverized kratom leaves are used for self-medication of pain, mood disorders, and opioid withdrawal symptoms. There are, however, no FDA-approved uses for kratom, and the vast majority of scientific research on kratom alkaloids focuses on their opioid receptor activity. To understand the promise and perils associated with kratom use, it is essential to elucidate the mechanisms underlying kratom’s pharmacology, including activities at other non-opioid targets. Based on kratom’s psychoactive profile, which includes acute antidepressant and anxiolytic effects, analgesic effects, and cardiac adverse effects at high doses, we hypothesized that certain kratom alkaloids have activity at serotonin (5-hydroxytryptamine, 5-HT) and alpha-adrenergic G protein- coupled receptors (GPCRs). The binding affinity and functional activity of selected kratom alkaloids—including mitragynine, speciogynine, and paynantheine—the three most abundant alkaloids were evaluated at 5-HT1ARs, 5-HT1BRs, 5-HT2ARs, 5-HT2BRs, 5-HT2CRs, 5-HT5Rs, 5-HT6Rs, and 5-HT7Rs. Mitragynine has been comprehensively demonstrated to be a mu-opioid receptor (MOR) partial agonist, however, a growing literature suggests an adrenergic component of mitragynine-mediated antinociception. To explore mitragynine's adrenergic action, we examined mitragynine's activity at G protein-dependent signaling pathways mediated by human alpha 1 (α1ARs) and alpha 2 adrenergic receptors (α2ARs). Results from the current study provide a better understanding of the complex polypharmacology of kratom alkaloids that contributes to its unique physiological effects.04/24/2024Canal, Clinton EMoniri, Nader HD'Souza, Martin JHasan, RaquibulHampson, Aidan JMcCurdy, Christopher RCrabtree, Brain LD.Phil
Deciphering The Effect of Xenobiotic Exposure on The Immunobiology of Human Mesenchymal Stem Cells & Their Interaction with Dendritic Cells
No full text2023Mesenchymal Stromal Cells (MSCs) are nonhematopoietic multipotent stem cells that possess a myriad of immunomodulatory and regenerative functions and thus maintain immune physiology and tissue homeostasis in the body. MSCs primarily carry out these functions through intercellular immune interactions involving paracrine secretion of secretory factors such as cytokine, chemokines, and growth factors. Previous study has extensively shown that MSCs display immunosuppressive properties on immune cells of lymphoid lineage; however, MSC’s interactions with cells of myeloid lineage such as dendritic cells require further research. Furthermore, given the central role of dendritic cells in immunity as antigen-presenting cells and the bridge between the innate and adaptive immune systems, it is important to understand how disruptions in the interactions between MSCs and dendritic cells can have implications on immune physiology. This project seeks to address this lack of knowledge by 1) identifying the interactions between human bone marrow derived MSCs and two circulating dendritic cells subtypes (plasmacytoid and myeloid) and by 2) defining the functionality of human bone marrow derived MSCs upon exposure to atrazine. MSC and dendritic cell interactions were investigated by conducting MSC and peripheral blood mononuclear cell (PBMCs) co-cultures under TLR7 or TLR4 stimulation. The presence of MSCs and TLR7 stimulation showed no effects on the function of the plasmacytoid dendritic cell subset. Contrarily, the presence of MSCs and TLR7 stimulation led to a decrease in maturation in the myeloid dendritic cell subset, as measured by CD83 expression using flow cytometry. Interestingly, MSCs present in a co-culture and TLR4 stimulation led to an increase in maturation in the myeloid dendritic cell subset. Secretome analysis of stimulated MSCs using multiplex assays suggests that secretory factors may be the reason for the results seen. Disruptions to MSC immune interactions were investigated by exposing MSCs to the xenobiotic herbicide atrazine at a range of dosages and for various durations of time. Cells were analyzed using an assay matrix comprising of MTT assays, flow cytometry, and multiplex assays. Atrazine was shown to affect MSC metabolic viability, size and granularity in a dose and time dependent manner. Atrazine exposure also modulates certain immunomodulatory and angiogenic secretory factors. Furthermore, atrazine exposure attenuates MSC responsiveness to exogenous cues, namely IFNγ. These results provide the context necessary in understanding how xenobiotic disruptions from atrazine exposure can affect immune interactions between MSCs and circulating dendritic cells.Chinnadurai, RaghavanRajapaksha, KamkaniDrummond, JamesM.S
Minutes of the General Association of the Baptist Denomination in Georgia [1825]
No full textMinutes of the Georgia Baptist Convention, 182
Minutes of the Thirty-Seventh Anniversary of the Baptist Convention of the State of Georgia [1859]
No full textMinutes of the Georgia Baptist Convention, 185
Minutes of the Fifty-Sixth Anniversary of the Baptist Convention of the State of Georgia [1878]
No full textMinutes of the Georgia Baptist Convention, 187
Minutes of the Seventy-First Anniversary of the Baptist Convention of the State of Georgia [1893]
No full textMinutes of the Georgia Baptist Convention, 189
Minutes of the Seventy-Third Anniversary of the Baptist Convention of the State of Georgia [1895]
No full textMinutes of the Georgia Baptist Convention, 189