Digital Commons at Lewis University
Not a member yet
246 research outputs found
Sort by
Splice-switching antisense oligonucleotides as therapeutic drugs
Get PDFSplice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA–RNA base-pairing or protein–RNA binding interactions that occur between components of the splicing machinery and the pre-mRNA. Splicing of pre-mRNA is required for the proper expression of the vast majority of protein-coding genes, and thus, targeting the process offers a means to manipulate protein production from a gene. Splicing modulation is particularly valuable in cases of disease caused by mutations that lead to disruption of normal splicing or when interfering with the normal splicing process of a gene transcript may be therapeutic. SSOs offer an effective and specific way to target and alter splicing in a therapeutic manner. Here, we discuss the different approaches used to target and alter pre-mRNA splicing with SSOs. We detail the modifications to the nucleic acids that make them promising therapeutics and discuss the challenges to creating effective SSO drugs. We highlight the development of SSOs designed to treat Duchenne muscular dystrophy and spinal muscular atrophy, which are currently being tested in clinical trials
Acceptance and Commitment Therapy (Chapter from The SAGE Encyclopedia of Marriage, Family, and Couples Counseling)
No full textAcceptance and commitment therapy (ACT) is an empirically based form of behavioral and cognitive treatment developed by psychologist Steven C. Hayes. ACT was originally developed to assist with the treatment of anxiety-based disorders but has been applied to numerous behavioral health issues since its conception. ACT is part of what has been called the third wave of behavioral and cognitive therapy, with its focus on mindfulness, acceptance, and values-based living. Since the development of ACT, it has been applied to a wide variety of clinical issues, including couples counseling. This entry provides an overview of the main tenets of this theory, discusses how these tenets are applied in treating couples, and describes the role of an ACT couples counselor.https://digitalcommons.lewisu.edu/psychology_fac-books/1002/thumbnail.jp
The abilities and decisions of regular and irregular voters in American presidential elections
No full textWhile most of the voter turnout literature focuses on the differences between voters and nonvoters, scant attention has been paid to what separates regular voters from the “irregular voters” who move in and out of the electorate. This article shows that citizens who regularly vote will be more knowledgeable and involved in the political system than voters who turnout irregularly. In addition, the article supports the existing claim that it is easier for voters to understand social policies than economic policies. These two principles lead to the hypothesis that economic and social policy preferences will predict the decisions of regular voters while the decisions of irregular voters will be predicted by social policy preferences but not economic preferences. American National Election Studies data from 1988 to 2008 provide support for these hypotheses. Though poor economic conditions may bring irregular voters out to the polls, their ballots are cast for candidates with similar social policy preferences, not necessarily similar economic stances
Who Is Responsible, the Incumbent or the Former President? Motivated Reasoning in Responsibility Attributions
No full textThis article establishes that transitions of power from one presidential administration to the next can act as a source of uncertainty regarding whom citizens view as responsible for national conditions. I argue that citizens confront this ambiguity in a partisan manner when making responsibility attributions of credit and blame. Using the economy and the Iraq War as examples, ordinary partisans frequently ascribe responsibility using motivated reasoning by crediting the president of their own political party for perceived successes and blaming the president of the opposite party for perceived failures
Hooking Up: The Psychology of Sex and Dating
No full textThis book is an engaging and comprehensive resource for high school and college students on modern topics in human sexuality, covering subjects such as gender roles and dating to sexual orientation and sex itself.Part of Greenwood\u27s The Psychology of Everyday Life series, this book gives readers a single-stop resource for learning about the intersections of psychology, human attraction, sexuality, cultural norms, and sexual behavior. Written in a compelling and straightforward style, readers will enjoy learning about the subject and come away with a new perspective on sex and sexuality.This overview covers popular topics in human sexuality such as the ubiquitous forms of sex in society (e.g., gender roles, sexual orientation, media and technology, cultural norms about sex), the importance of sex in every individual\u27s life, the positive and negative effects of sex, specific psychological theories and theorists, sex over the developmental lifespan, and different cultural perspectives on topics in human sexuality. The presentation of topics in the book builds logically on previously covered material; however, the information is presented so that students looking for specific information can read chapters out of order and still understand the primary content areas.https://digitalcommons.lewisu.edu/psychology_fac-books/1023/thumbnail.jp
