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Human Papillomavirus Self-Sampling for Unscreened Women Aged 24 Years During the COVID-19 Pandemic
Full text link福井大学博士(医学)2024doctoral thesi
Educational practices that promote the acquisition of the ability to grasp graphs and the ability to fix variables of multivariable functions in high school
Full text link学校数学で多変数関数を学習する意義は指摘されているものの，現行の関数領域のカリキュラムでは，1変数関数の学習しかおこなわれていない。そこで本研究では，高校生を対象に2変数関数について「グラフの概形を捉える力」と「変数固定の見方」に焦点を当てて教育実践を行った。その結果，立体グラフ模型の観察を中心とした教授活動によって，1変数関数の問題を繰り返し解くだけでは得られない多変数関数のグラフの概形を捉える力と変数固定の見方の獲得が促進されることが明らかとなった。departmental bulletin pape
Utility of echocardiographic parameters in predicting cardiac immune-related adverse events in Japanese patients undergoing immune checkpoint inhibitor therapy
Full text link福井大学博士(医学)2025Background
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are associated
with immune-related adverse events, including cardiac immune-related adverse events
(cardiac irAEs). Early identification of patients at risk for cardiac irAEs is crucial, and
echocardiographic parameters may serve as valuable predictors. This study aimed to evaluate
the predictive utility of echocardiographic indices in assessing cardiac irAE risk in Japanese
patients receiving ICI therapy.
Methods
This retrospective study analyzed patients treated with ICIs at the University of Fukui Hospital
between November 2015 and October 2018. Cardiac irAEs were defined according to
the ESC guidelines.
Results
Among 73 patients, six (8%) developed cardiac irAEs, with no fatalities. Echocardiographic
assessment before ICI initiation revealed that patients who later developed cardiac irAEs
had significantly lower ejection fractions (EFs) (p < 0.05). Receiver operating characteristic
analysis demonstrated that left ventricular end-systolic diameters (LVDs)
(area under the curve: AUC = 0.660) and EFs (AUC = 0.797) had moderate predictive value for
cardiac irAEs. Kaplan–Meier analysis showed a higher probability of cardiac irAEs in patients
with LVDs and EFs beyond specific thresholds (p < 0.01). Poisson regression analysis indicated
a decreasing risk of cardiac irAEs over time after ICI initiation.
Conclusion
Baseline echocardiographic parameters, particularly LVDs and EFs, can be useful predictors
of cardiac irAEs in patients receiving ICI therapy. Early echocardiographic evaluation may facilitate
risk stratification and improve monitoring strategies for cardiac irAEs.
Clinical trial registration number
UMIN000023840.doctoral thesi
Development of Electrospun PNIPAM Hydrogel Fibers for Actuator Applications
Full text link福井大学博士(工学)2025doctoral thesi
