Central Asian Journal of Medical and Natural Science
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Synthesis, Docking, and Biological Activity of Chalcone and Metal Complexes
No full textThis study investigates the synthesis and characterization of chalcone derivatives and their metal complexes, focusing on their potential pharmacological activities and antibacterial effects. Specifically, the research explores the preparation of 1-(4-hydroxyphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (R5) chalcone and its complexes with Ni(II), Co(II), and Cd(II). Various physical and spectral techniques were employed for characterization, including FT-IR, UV, and NMR spectroscopy. The antibacterial activity of the synthesized compounds was evaluated against antibiotic-resistant bacterial strains, revealing notable inhibitory effects. Molecular docking studies were conducted to assess the compounds' interactions with the active sites of Pseudomonas aeruginosa protein. Results suggest that the prepared compounds and complexes exhibit promising antibacterial properties and have the potential for further medicinal chemistry applications. This research fills a knowledge gap regarding the synthesis, characterization, and biological activities of chalcone derivatives and their metal complexes, providing insights for future drug discovery efforts in combating bacterial infections
IMMUNOLOGICAL EFFECTIVENESS OF IMMUNO- AND BIOCORRECTIVE TREATMENT OF DENTAL DISEASES IN PREGNANT WOMEN
No full textDuring pregnancy, inflammation and retraction of the gums, marginal periodontitis, a decrease in the density of collagen fibers in the periodontium, a decrease in the mesiodistal diameter of the interdental septa can develop from the maxillofacial region, which leads to fibrous degeneration of the walls of periodontal blood vessels and, as a result, the development of periodontitis [1, 2, 9]
ENVIRONMENTAL POLLUTIONFROM FARM ANIMAL WASTE
No full textThe article presents a digital material illustrating the sanitary and hygienic problem that has arisen as a result of environmental pollution (atmospheric air, water, soil) by livestock and poultry waste due to imperfect technology for keeping farm animals (ventilation system, microclimate optimization and disposal of solid and liquid production waste). It is shown how many and what kind of waste products an agricultural animal (poultry, pigs, cattle) releases during different periods of ontogenesis and what volumes of them, not disposed of, are stored, polluting the habitat of animals and humans with substances harmful to their health (ammonia, hydrogen sulfide, urea, protein decomposition products and others). Numerous pathogenic organisms enter the soil, groundwater and surface waters with manure, droppings, and sewage, which retain their viability and virulence for a long time, maintaining the circulation of pathogens of dangerous diseases of farm animals and humans (salmonellosis, brucellosis, tuberculosis, helminthiasis, coccidiosis and others). The abundance of animals in agricultural complexes with suboptimal cultivation technology contributes to the spread and maintenance of various dangerous diseases that reduce the productivity and vitality of animals
ИЗУЧЕНИЕ БИОЛОГИЧЕСКИ АКТИВНЫХ ВЕЩЕСТВ, СОДЕРЖАЩИХСЯ В СОСТАВЕ СУХОГО ВОДНОГО ЭКСТРАКТА ВАЙДЫ КРАСИЛЬНОЙ
No full textВ результате исследования были изучены биологически активные вещества Вайды красильной (Isatis tinctoria), такие как флавоноиды, витамины и полисахариды
EVALUATION THE ROLE OF HEPCIDIN IN LYMPHOMA PATIENTS
No full textBackground: Lymphoma are group of diseases caused by malignant Lymphocyte that accumulate in lymph nodes and cause the characteristic clinical features of lymphadenopathy. Anaemia is a common feature in lymphoproliferative disease. Hepcidin: is a liver produced acute phase peptide whose overproduction leads to iron limited erythropoiesis. Aim of the study: To assess the level of hepcidin in newly diagnosed lymphoma patients. And correlate it with Hb, stage of disease, bulky disease, and B-symptoms. Patients and methods: Forty patients with newly diagnosed lymphoma were consequently selected from the haematology outpatient clinic at the Medical City24 of them were male and 16 were female. The level of hepcidin was investigated by ELISA technique. Results: The mean age for Lymphoma participants in this research was 43. 6±20. 2 years with range of (14-79) years. M:F ratio was 1. 5:129 patients were anaemic with Hb less than 12g /dL, 21patients had stage IV disease (52. 5%), 7 patients had stage III disease (17. 5%),12 patients had stage II disease (30%). Hepcidin level was significantly increased in lymphoma Patients than control group. There was significant inverse relationship between hepcidin with Hb level. There was significant positive relationship between hepcidin level with the presence of B-symptoms and stage of the disease. Conclusion: Hepcidin level was significantly increased in lymphoma patients compare to healthy control. It was significantly higher in lymphoma patient with anaemia than no anaemic patients. The adverse impact of elevated hepcidin is consistent with demonstration of higher level of hepcidin in patients with B symptoms and advanced stages
THE IMPORTANCE OF ELECTRONIC CONSENT FORMS IN CLINICAL RESEARCH
No full textClinical research, a cornerstone of medical progress, is an intricate and dynamic field aimed at advancing our understanding of diseases, developing innovative treatments, and improving overall healthcare outcomes. The background of clinical research is deeply rooted in the pursuit of knowledge and the desire to enhance medical practices. Historically, clinical research has been driven by the need to address unanswered questions in medicine and to find effective interventions for various health conditions
ОПЫТ ПРИМЕНЕНИЯ СОМАТУЛИНА В ЛЕЧЕНИИ БОЛЬНЫХ АКРОМЕГАЛИЕЙ
No full textЧетверо пациентов с акромегалией получали лечение препаратом из группы аналогов соматостатина пролонгированного действия соматулином 30 мг в течение пяти – шести месяцев. Ранее двум больным была сделана субтотальное аденомэктомия. Все больные три – четыре года назад прошли курс Y- терапии в дозе 40 – 50 грей.
Перед началом введения соматулина базальный уровень СТГ у всех больных был высокий – от 57 до 160 МКМЕ/мл, и продолжали прогрессировать клинические проявления акромегалии.
Через пять месяцев у двоих больных содержание СТГ в крови значительно снизилось, у двоих нормализовалось. У всех больных уменьшилась отечность лица, кистей стоп, прошли головные боли. Уменьшились другие симптомы акромегалии. Значимых побочных эффектов не отмечено
PERINATAL OUTCOMES IN ACUTE RESPIRATORY VIRAL INFECTION IN PREGNANT WOMEN
No full textRespiratory viral infections in the process of human civilization manifested themselves through various viral infections. In the XXI century, COVID-19 became a global problem in the history of mankind, and the causative agent of which was the SARs-CoV-2 virus and was the cause of a pandemic around the world, and today this virus has turned into a seasonally aggravated respiratory viral infection. This virus can also cause serious health problems during pregnancy. Unlike the general population, pregnant women constitute a special group with a significantly higher risk of viral infection as a unique "immunological" condition and a change in the function of all organs and systems during pregnancy, in this regard, the study of the functional state of the mother-placenta-fetus system in pregnant women, the course of pregnancy, complications and perinatal outcomes, as well as the condition of newborns in women who have suffered viral infections remains a modern requirement from a scientific and practical point of view
The Usefulness and Discrimination Power of DYS391 Locus Using Power Plex ® Fusion and Power Plex®23Y Systems in Paternity Testing
No full textThirty random cases of Iraqi families contain data of father/son DNA haplotypes have been analyzed between 2017-2022 to find out the usefulness of DYS 391 Locus in paternity testing using power-plex ®fusion and power-plex ®Y23systems. Scientifically, all cases were confirmed and officially reported as an absolute cases of exclusion paternity. A combination of the two systems should permit effective analysis with sufficient diversity and discrimination power of the locus. The results show significant match (i.e., inclusion) at the DYS391 locus between alleged fathers and corresponding sons for both kits in all the cases meanwhile there were no match (i.e., exclusion) in many autosomal DNA loci and the rest Y-haplotypes other than DYS391. Furthermore, the results revealed only three DYS391 allele polymorphisms; Allele number 10,11and 9 in a percentage of 69.23%, 27.692% and 3.076% contained in all 30 cases respectively. Allele frequencies, homozygosity, haplotype diversity (HD), match probability and the power of discrimination of DYS391 locus (PD) were estimated. The observed allele frequencies were (0.692, 0.276 and 0.030) for allele numbers 10, 11 and 9 respectively. Homozygosity was found to be (0.478, 0.0761 and 0.0009) respectively too. Measurement of the upper bound confidence interval (CI) for each corresponding allele was (2.642, 2.234 and 1.989). Haplotype diversity was (0.451) and combined power of discrimination for DYS391 Locus was (0.4442). As a conclusion, there is a limitation in certifying DYS391 locus as an exclusive locus useful Y-STR in testing paternity and male lineage in autosomal STR kits because of little allele variants, poor power of discrimination and gene diversity
Influential Factors Affecting the Effective Delivery of Services by Health Records Professionals in Selected Tertiary Teaching Hospitals in Southwestern Nigeria
No full textHealthcare service delivery in Nigeria, particularly in the Southwestern region, faces significant challenges, including inadequate infrastructure and staffing shortages. Health records management practices are crucial for improving service delivery and health outcomes. This study examines influential factors affecting the effective delivery of services by health records professionals in selected Tertiary Teaching Hospitals in Southwestern Nigeria. The study aims to investigates factors such as staffing levels, technological infrastructure, training opportunities, and organizational barriers affecting service delivery. It also aim to assess the perceptions and challenges faced by health records professionals in delivering services effectively. A cross-sectional study design was employed, utilizing a stratified sampling technique to select 200 respondents from three Tertiary Teaching Hospitals in Southwestern Nigeria. Data were collected through a structured questionnaire and analyzed using descriptive statistics, including frequency tables, to present results. The study reveals positive perceptions among respondents regarding various services delivered by health records professionals. However, challenges such as inadequate staffing levels and resistance to change within organizational culture were identified. While some factors like standardized procedures (50.0% agreeing) and access to training opportunities (42.7% agreeing) were perceived positively, concerns about resource allocation equity (47.5% disagreeing) and technological infrastructure (42.5% agreeing) persisted. The findings underscore the importance of addressing systemic issues to improve health records management and service delivery. Recommendations include addressing staffing shortages, investing in technology, providing training opportunities, enforcing policies, and ensuring resource equity. Enhancing health records management practices can lead to improved patient care and healthcare service delivery in Tertiary Teaching Hospitals in Southwestern Nigeria