Central Asian Journal of Medical and Natural Science
Not a member yet
2104 research outputs found
Sort by
Insights on Extracting Bio-Active Compounds from Plants that Act Against Bacteria (Article Review)
No full textGreen technology is the worldwide urgent demand all over the world since various bioactive compounds are in use daily effecting by their composition man’s health that led to the optimization for a most beneficial technique for extracting essential materials and compounds, the need for safe and effective methods in extracting essential compounds were raised among these novel methods: extracting for Bioactive Materials by Supercritical and subcritical fluid Extraction, by Ultrasound assisted Extraction, by Negative Pressure Cavitation Assisted Extraction, by Microwave Assisted Extraction, by Pressurized Liquid and Hot Water Extraction, by High Pressure Assisted Extraction, by Enzyme Assisting and many other methods which are all green and environmentally friendly. Researches proceed in inventing new effective green methods of novelty. This could be aided by the previous techniques and their yields quality and amount with less time, cost, energy, human interference. Our review highlights how these environmentally friendly techniques can enhance the recovery of bioactive compounds, with the goal of influencing future extraction procedures and industrial uses in food, cosmetics, and pharmaceuticals
Study Of Quality Indicators Of Tablets "Enformin" and "Sitmet" With Antidiabetic Effect
No full textThis study evaluates the quality indicators of two antidiabetic tablet formulations, "Enformin" and "Sitmet," focusing on their technological properties and compliance with pharmacopoeial standards. The research aimed to identify compositions that optimize tablet quality through the addition of auxiliary substances. Five compositions for each tablet were analyzed for properties such as hardness, friability, dissolution rate, and moisture absorption. Rigidity and disintegration tests revealed that "Enformin" composition ET-3 and "Sitmet" composition ST-5 consistently met or exceeded quality standards. Moisture absorption studies confirmed low hygroscopicity for both formulations, while residual moisture and compression pressure studies established optimal manufacturing parameters for producing high-quality tablets. Results indicate that specific compositions and manufacturing conditions directly influence the physicochemical properties, ensuring tablet stability and efficacy. These findings provide a basis for scaling up production to meet growing local demands for antidiabetic drugs, in alignment with Uzbekistan's pharmaceutical development goals
CLINICAL MANIFESTATIONS, PREVENTION AND TREATMENT OF STROKE IN WOMEN
No full textStroke is an acute disorder of blood circulation in the brain, accompanied by tissue death and impaired function of the nervous system. Normally, brain tissues constantly receive sufficient nutrients and oxygen to maintain organ function. Stopping blood flow even for a few seconds can lead to damage to the organ, as neurons do not store the necessary components for metabolism. Stroke is a life threatening condition: depending on the area of blood flow disruption, the patient may experience mild impairment of brain function or massive tissue destruction followed by a vegetative state. Early symptoms of the disease include muscle weakness, speech impairment and facial asymmetry
ПРОГНОЗИРОВАНИЕ ОТКЛОНЕНИЙ ФИЗИЧЕСКОГО РАЗВИТИЯ ДЕТЕЙ В ЗAВИСИМOСТИ OТ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ
No full textВ педиатрии в последнее время большое внимание уделяется проблеме изучения состояний, сопровождающихся увеличением щилочковой железы. Высокая частота выявления эндемического зоба и отставания в психомоторном развитии среди детей привлекает к этой проблеме внимание иммунологов, эндокринологов, морфологов. Статья посвящена оценке физического развития детей в зависимости от функционального состояния щитовидной железы
SPECTROSCOPY, THERMAL ANALYSIS, BIOAVAILABILITY AND ANTICANCER ACTIVITY OF COPPER (II) COMPLEX WITH HETEROCYCLIC AZO DYE LIGAND
No full textIn this study, we investigate the binding of copper ion to a unique compound called (E)-2-((4, 5-diphenyl-1H-imidazol-2-yl) diazenyl) benzoic acid (IABA). Through various tests, including spectroscopy, physical analysis, and thermal measurements, we were able to confirm the structures of the synthesized compounds. Our results showed that the copper (II) complexes had a 1:2 ratio of metal ions to IABA ligand.
The ligand made up of azo dye dazzles the copper ion with its three distinct arms, featuring the mighty nitrogen atom of the azo component, the nitrogen atom of the azo group in the heterocyclic imidazole ring, and finally the oxygen atom of the carboxyl group. Thermal analysis techniques such as thermogravimetry and differential thermogravimetry were utilized to demonstrate the thermal properties of the copper complexes, revealing their higher degree of stability compared to the ligands.
The ligand and copper (II) complex that was prepared displayed noteworthy effects against cancer, with an IC50 value indicating its capacity to hinder the growth of malignant cells. The IC50 values for cytotoxicity against WRI-68 were recorded at 185.7 μg/ml for the ligand and 200.7 μg/ml for the copper (II) complex, while the specific cytotoxicity of the copper (II) complex did not align with the targeted disease cell lines, with IC50 values of 100.1 μg/ml and 330.1 μg/ml for WRI-68. The Cu (II) complexes showed strong effectiveness in inhibiting the growth of both Streptococcus (gram-positive bacteria) and Salmonella enterica serovar Typhi (gram-negative bacteria)
An Investigation on Poor Oral Hygiene Practices Effect on Dental Caries and Malocclusion Rates Among Teenagers Attending Southern Iraqi Secondary Schools
No full textAmong the prevalent oral conditions affecting adolescents are caries and malocclusion deformity. This study examined the impact of variables including bad dental practices on teenage caries in order to investigate the relationship between malocclusion deformity and caries prevalence. The research subjects for this study were 184 teenagers, aged 11 to 14, who were enrolled in four secondary schools in Nasiriyah, southern Iraq, during the 2018–2019 academic year. These teenagers' basic information was gathered using questionnaires. By doing an on-site examination, malocclusion and caries were examined. We also investigated their bad dental habits. Following the acquisition of data, multivariate analysis was conducted using the chi-square test, logistic regression, Mann-Whitney U test, and Kruskal-Wallis H test. In this region, among teenagers aged 11-14, the frequency of malocclusion was found to be 26.63%, while the caries rate was 60.68%. The four bad oral behaviors that affected malocclusion in teenagers were biting, mandibular protrusion, lateral chewing, and mouth breathing. Malocclusion, poor dental hygiene, and frequent use of sugary drinks were all found to be independent risk factors for dental caries in teenagers and to be positively correlated with the caries rate. In adolescents, malocclusion and harmful oral practices were independent risk factors for dental caries
КЛИНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ МИНИИНВАЗИВНЫХ ВМЕШАТЕЛЬСТВ В ХИРУРГИЧЕСКОМ ЛЕЧЕНИИ ОСЛОЖНЕНИЙ ЖЕЛЧНОКАМЕННОЙ БОЛЕЗНИ
No full textВ работе проведен анализ результатов хирургического лечения 83 больных с острым холециститом и холедохолитиазом. Этапное хирургическое лечение с применением предварительных декомпрессивных вмешательств на желчевыводящих протоках позволило купировать явления холестаза и гнойной интоксикации, улучшить результаты радикальных операций. При этом необходимость в применении диапевтических и эндоскопических трансдуоденальных вмешательств было у 81,8% больных с тяжелой степенью, 61,6% средней степени тяжести и 24,1% с легкой степени тяжести острого гнойного холангита. Оптимизация тактико – технических аспектов комплексного хирургического лечения больных острым холециститом и холедохолитиазом осложненным острым гнойным холангитом позволило значимо уменьшить послеоперационные гнойно – септические и холемические осложнения до 12,1%, летальности до 2,4%
ГЕМОРРАГИЧЕСКИЙ СИНДРОМ У ДЕТЕЙ РАННЕГО ВОЗРАСТА
No full textВ данной статье изложены мнения отечественных и зарубежных ученых о геморрагическом синдроме у детей раннего возраста
DETERMINATION OF CANCER MARKER CARCINOEMBRYONIC ANTIGEN (CEA) AND LEVELS OF REPRODUCTIVE HORMONE, TESTOSTERONE IN SERUM OF SMOKER MAN THAT CORRELATE TO SEMEN PARAMETERS IN BAGHDAD CITY CAVIL’S
No full textObjective: Subfertility, erectile dysfunction, recurrent abortions, and other health problems are associated with smoking, which is a rapidly expanding global epidemic. Furthermore, the impact on the male endocrine system, particularly testosterone levels, is an ongoing topic of debate due to the contradictory findings that have been recorded. Using a non-smoking control group (n=50) and a group of male smokers (n=90), the researchers examined the effects of smoking on serum free testosterone (T) and carcinoembryonic antigen (CEA). In regards to serum free testosterone (T), which was 15% higher in smoker cases (p < 0.01), and on carcinoembryonic antigen (CEA), and the P values is < 0.001 and less than 0.001, respectively, our study found a positive and statistically significant difference between the smoker and non-smoker groups. Furthermore, a negative link between smoking duration and semen parameters was shown to be statistically significant (p < 0.01). Conclusion: Further evidence that smoking has beneficial effects on blood testosterone and CEA concentrations was added to the current investigation
СОСТОЯНИЕ ОРГАНОВ И ТКАНЕЙ ПОЛОСТИ РТА У ЛЮДЕЙ, СВЯЗАННЫХ С ВРЕДНОЙ ПРОМЫШЛЕННОСТЬЮ И ПРОЖИВАЮЩИХ В ЭКОЛОГИЧЕСКИ НЕБЛОГОПРИЯТНЫХ ЗОНАХ
No full textВ данной статье автор подробно рассмотрел существующие проблемы, связанные с состоянием здоровья, особенно с состоянием здоровья полости рта работников различных промышленных предприятий, в том числе и жителей, проживающих в этой экологической зоне. Автором проведён подробный анализ научных исследований, посвящённых изучению механизмов негативного влияния промышленных отходов как на организм человека в целом, так и на органы и ткани полости рта, изучению их структуры, клиники и формированию патологических процессов. Заключение по результатам проведенного исследования выявлены негативные (отрицательные) факторы, возникающие в результате технологического процесса производства, которые являются главными причинами появления и формирования стоматологических заболеваний, возникновения соматическими заболеваний и связанных с ними ряда осложнений, так при оказании ортопедической стоматологической помощи, необходимо учитывать значение выше указанных факторов